Validation of self-reported cardiovascular problems in childhood cancer survivors by contacting general practitioners: feasibility and results

Table 1 Characteristics of study population: SCCSS responders without cardiovascular problems vs. responders with cardiovascular problems

	SCCSS responders without cardiac problems (n = 1867)		SCCSS responders with cardiac problems^a (n = 290)		Total (n = 2157)
	n	%^b	n	%^b	n	%^b	p-value^c
Sex							0.270
Male	1024	55	149	51	1173	54
Female	843	45	141	49	984	46
Nationality							0.704
Other	187	10	27	9	214	10
Swiss	1678	90	263	91	1941	90
Language region							0.286
German	1340	72	217	75	1557	72
French/Italian	526	28	73	25	599	28
Age at study							< 0.001
< 20y	815	44	76	26	891	41
20-29y	727	39	134	47	861	40
30-39y	285	15	60	21	345	16
40y +	40	2	18	6	58	3
Age at diagnosis							0.001
0–4 years	856	46	111	38	967	45
5–9 years	492	26	69	24	561	26
10 years and more	519	28	110	38	629	29
Diagnosis (ICCC-3)							0.013
I Leukemia	661	35	102	35	763	35
II Lymphoma	285	15	65	22	350	16
III CNS tumor	282	15	26	9	308	14
IV Neuroblastoma	97	5	15	5	112	5
V Retinoblastoma	67	4	6	2	73	3
VI Renal tumor	130	7	19	7	149	7
VII Hepatic tumor	16	1	2	1	18	1
VIII Bone tumor	71	4	16	6	87	4
IX Soft tissue sarcoma	106	6	12	4	118	6
X Germ cell tumor	56	3	9	3	65	3
XI & XII Other tumor^d	25	1	1	0	26	1
Langerhans Cell Histiocytosis	71	4	17	6	88	4
GP consultations last year							0.003
no	705	38	83	29	788	37
yes	1162	62	207	71	1369	64
Self-reported cardiovascular problems^e
Hypertension	0	0	96	33	96	5
Arrhythmia	0	0	73	25	73	3
Congestive heart failure	0	0	41	14	41	2
Myocardial infarction	0	0	2	1	2	0
Coronary heart disease	0	0	23	8	23	1
Stroke	0	0	7	2	7	0
Thrombosis/Embolism	0	0	23	8	23	1
Valvular problems	0	0	38	13	38	2
Other	0	0	57	20	57	3

NOTE: Percentages are based upon available data for each variable
Abbreviations: CNS, Central Nervous System; GP, general practitioner; ICCC-3, International Classification of Childhood Cancer - Third Edition; n, number; SCCSS, Swiss Childhood Cancer Survivor Study; y, years
^a Participants of the Swiss Childhood Cancer Survivor Study (SCCSS) who reported a cardiovascular problem in the questionnaire survey
^b Column percentages are given
^cP-value calculated from chi-square statistics (dichotomous variables) or nonparametric trend tests (ordered categorical variables) comparing SCCSS participants with and without cardiovascular problems
^d Other malignant epithelial neoplasms, malignant melanomas and other or unspecified malignant neoplasms
^e Each participant could have had more than one cardiovascular problem

ISSN: 2731-4553