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Table 3 Newly diagnosed hypertensive patients (2016-2019q1) with different types of medical therapies

From: Quality of care in patients with hypertension: a retrospective cohort study of primary care routine data in Germany

Variable

None

Mono

Combination

p-valuea

n(%)

651(32.2)

n(%)

458(22.6)

n(%)

914(45.2)

 

BP measurement during first 1.5 years of disease

 BP measured, n (%)

128(19.7)

364(79.5)

782(85.6)

 < 0.0001b

 number of BP measurements, µ

0.4

2.3

3.6

 < 0.0001

 BP measured at least 3 times, n (%)

35(5.4)

162(35.4)

501(54.8)

 < 0.0001b

 ABPM, n (%)

18(2.8)

77(16.8)

160(17.5)

 < 0.0001b

 Basis diagnostic, n (%)

12(1.8)

35(7.6)

96(10.5)

 < 0.0001b

 Health Check-up, n (%)

52(8.6)

146(41.5)

336(51.3)

 < 0.0001b

Therapy during sample period

 Number of different drugs, µ

-

2.7

8.2

 < 0.0001

 Number of different ATCs, µ

-

1.0

2.7

 < 0.0001

 Number of different APIs, µ

-

1.1

3.2

 < 0.0001

Most prevalent APIs

 Ramipril, (%)

-

206(45.0)

429(46.9)

 < 0.0001b

 Bisoprolol, (%)

-

58(12.7)

294(32.2)

 < 0.0001b

 Amlodipine, (%)

-

25(5.5)

263(28.8)

 < 0.0001b

 Candesartan, (%)

-

51(11.1)

201(22.0)

 < 0.0001b

 Torasemidec, (%)

-

32(7.0)

165(18.1)

 < 0.0001b

 Metoprolol, (%)

-

26(5.7)

151(16.5)

 < 0.0001b

BP measures at the beginning of disease

 Systolic mmHg, µ/N

137.8/92

142.7/275

139.2/564

 > 0.999

 Diastolic mmHg, µ/N

81.5/92

84.5/275

80.8/564

0.0016

  > 140/90 mmHg, n/N(%)

23/92(25.0)

95/275(34.5)

121/564(21.5)

0.0059b

   < 140/90 mmHg, n/N(%)

38/92(41.3)

99/275(36)

250/564(44.3)

 > 0.999b

BP measures after one year of diagnosis

 Systolic, µ/N

134.2/45

136.6/160

137.5/517

 > 0.999

 Diastolic, µ/N

80.6/45

81.3/160

80.1/517

 > 0.999

   > 140/90 mmHg, n/N(%)

10/45(22.2)

33/160(20.6)

95/516(18.4)

 > 0.999b

   < 140/90 mmHg, n/N(%)

23/45(51.1)

75/160(46.9)

249/516(48.3)

 > 0.999b

BP measures differences

 Systolic (Δ), µ/N

1.2/20

3.2/95

-0.2/350

 > 0.999

 Diastolic (Δ), µ/N

-1.9/20

0.2/95

0.1/350

 > 0.999

  1. BP Blood pressure, ABPM 24-h Ambulatory Blood Pressure Monitoring, API Active pharmaceutical ingredient, ATC Anatomical therapeutic chemical classification code,  Monotherapy: prescription of drugs with one API; Combination therapy: prescription of drugs with more than one API; µ: mean; N: number of observations with non-missing data; aBonferroni corrected. Italicized records indicate p-values > 0.05. bχ2 test. c Torasemide is generally not used primarily to lower blood pressure, but to treat fluid retention due to heart, kidney, or liver disease