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Table 3 Evidence summary [17] of cognitive tests for dementia (dementia versus no dementia)

From: How to choose the most appropriate cognitive test to evaluate cognitive complaints in primary care

Test Studies (n) Test time (min) Cut-off score Study population, % dementia Number of participants analysed Sens (95% CI) Spec (95% CI) PPV (95% CI) NPV (95% CI)
AMT 2   7/8 29 269 42 (31, 53) 93 (89, 96) 71 (56, 83) 80 (74, 85)
   7/8 4 358 92 (64, 100) 95 (93, 97) 43 (25, 63) 100 (98, 100)
Mini-Cog 2 3–4 2/3 40 371 97 (93, 99) 71 (65, 77) 71 (64, 77) 97 (93, 99)
   2/3 3 630 76 (54, 90) 73 (69, 76) 9 (5, 14) 99 (97,100)
MIS 3 4 4 10 483 80 (66, 90) 96 (94, 98) 70 (57, 82) 98 (96, 99)
   4 18 318 76 (42, 100) 73 (56, 96) 38 (29, 47) 94 (89, 97)
   4 12 240 86 (67, 96) 97 (94, 99) 80 (61, 92) 98 (95, 100)
MMSE 5 7–10 23/24 4 1115 91 (78, 98) 87 (85, 89) 23 (17, 29) 100 (99, 100)
   23/24 1 709 87 (78, 95) 89 (86, 92) 52 (44, 60) 98 (96, 99)
   23/24 4 358 77 (46, 95) 97 (94,98) 46 (24, 68) 99 (97, 100)
   23/24 6 648 88 (74, 96) 88 (85, 90) 32 (24, 42) 99 (98, 100)
   23/24 28 360 84 (75, 90) 88 (84, 92) 73 (64, 81) 94 (90, 96)
MMSE 4 7–10 24/25 29 283 81 (70, 88) 76 (70, 82) 57 (48, 67) 90 (85, 95)
   24/25 4 269 98 (78, 100) 84 (79, 87) 21 (13, 33) 100 (99, 100)
   24/25 14 274 85 (70, 94) 81 (75, 86) 42 (31, 54) 97 (94, 99)
   24/25 19 449 84 (75, 91) 83 (79, 87) 55 (46, 63) 96 (93, 98)
MSQ 2 4 7/8 16 164 100 (87, 100) 84 (76, 89) 54 (39, 69) 100 (97, 100)
   7/8 4 358 92 (64, 100) 98 (96, 99) 67 (41, 87) 100 (98, 100)
SPMSQ 2 3–4 7/8 3 119 100 (29, 100) 100 (97, 100) 100 (29, 100) 100 (97, 100)
    7/8 4 358 100 (75, 100) 97 (94, 98) 54 (33, 75) 100 (99, 100)
  1. Only the studies reporting a cut-off score that was studied more than once are depicted in the table. Abbreviations: CI Confidence Interval, MCI Mild Cognitive Impairment, NR Not Reported; Sens Sensitivity, Spec Specificity, NPV Negative Predictive Value, PPV Positive Predictive Value, AUC Area Under the Curve. Abbreviations cognitive tests: AMT Abbreviated Mental Test, MIS Memory Impairment Screen, MMSE Mini Mental State Examination, MSQ Mental Status Questionnaire, SPMSQ Short Portable Mental Status Questionnaire