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Table 3 Comparison of acute cystitis decision aid performance in the development [8] and validation cohorts of women with acute cystitis

From: External validation study of a clinical decision aid to reduce unnecessary antibiotic prescriptions in women with acute cystitis

Outcome Development Cohort [8] (2002) Validation Cohort (2009–2011) Absolute Difference p-value*
Number of Family Physicians 205 230
Women with complete data 331 397
Prevalence of positive cultures 208/331 (62.8%) 245/397 (61.7%) - 1.1% 0.76
1. Accuracy
 Sensitivity 167/208 (80.3%) 202/245 (82.5%) + 2.1% 0.54
 Specificity 66/123 (53.7%) 54/152 (35.5%) - 18.2% 0.005
2. Management
 Urine Cultures 107/331 (32.3%) 97/397 (24.4%) - 7.9% 0.02
 Antibiotics Prescribed 224/331 (67.7%) 300/397 (75.6%) + 7.9% 0.02
 Unnecessary Antibiotics** 57/331 (17.2%) 98/397 (24.7%) + 7.5% 0.02
  1. *adjusted for clustering by physician
  2. **antibiotic prescription issued and subsequent urine culture was negative for bacteria
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