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Table 1 Symptoms and signs most frequently noted in those with CFS/ME

From: Investigating unexplained fatigue in general practice with a particular focus on CFS/ME

Symptoms Signs
Aching muscles, 90 %+, Pharyngitis, 25 %
Non-Restorative sleep, 95 %+ Cervical tenderness with or without lymphadenopathy 25 %
Daytime nap 3+ times per week, 30 %
Muscle weakness, 90 %+ Axillary lymph nodes 10 %
Impaired concentration, 90 % Cold peripheries in moderate, severe and very severe ME −70 + %
Forgetfulness, 85 %
Muddled thinking, 80 %+
Aching joints, 85 %+ Temperature >37.5C but <39.0C, 10 %
Stress aggravated Fatigue, 90 % Increased respiratory rate, 80 + %
Headaches 75 % Altered pupil reflexes, 60 %
Weight gain, 50 %  
Orthostatic intolerance 60 % [according to the IOM – [7]