Table 2 Means (and 95% CI:s) of metabolic parameters for subjects who completed the study. Mean differences between groups were obtained with analyses of covariance with the baseline value as a covariate. Means at three and six months are estimated marginal means. GHbA1c = glycosylated haemoglobin A1c.
Placebo (n = 14) | Paroxetine (n = 23) | Placebo – Paroxetine | ||
|---|---|---|---|---|
Mean (95% CI) | Mean (95% CI) | Mean difference (95% CI) | p | |
GHbA1c (%) | ||||
Baseline | 9.0 (8.2 to 9.8) | 8.5 (8.0 to 8.9) | 0.54 (-0.24 to 1.31) | 0.169 |
3 months | 8.5 (8.2 to 8.9) | 7.9 (7.6 to 8.2) | 0.59 (0.11 to 1.07) | 0.018 |
6 months | 8.4 (7.9 to 8.9) | 8.3 (7.9 to 8.7) | 0.13 (-0.52 to 0.78) | 0.693 |
Serum glucose (mmol/l) | ||||
Baseline | 10.7 (8.6 to 12.8) | 10.4 (8.8 to 12.0) | 0.27 (-2.27 to 2.81) | 0.829 |
3 months | 10.7 (9.8 to 12.5) | 9.7 (8.2 to 11.1) | 1.05 (-1.26 to 3.35) | 0.362 |
6 months | 10.8 (9.1 to 12.5) | 10.2 (8.8 to 11.5) | 0.59 (-1.56 to 2.74) | 0.580 |
Serum C-peptide (nmol/l) | ||||
Baseline | 0.6 (0.3 to 0.8) | 0.7 (0.5 to 0.9) | -0.15 (-0.46 to 0.15) | 0.310 |
3 months | 0.8 (0.6 to 0.9) | 0.8 (0.7 to 1.0) | -0.04 (-0.25 to 0.16) | 0.656 |
6 months | 0.7 (0.6 to 0.9) | 0.8 (0.7 to 0.9) | -0.04 (-0.21 to 0.14) | 0.682 |
Body mass index (kg/m2) | ||||
Baseline | 31.1 (29.3 to 34.1) | 31.7 (29.8 to 33.1) | -0.66 (-4.14 to 2.82) | 0.704 |
3 months | 31.1 (30.7 to 31.6) | 31.0 (30.6 to 31.3) | 0.15 (-0.44 to 0.73) | 0.614 |
6 months | 31.4 (30.9 to 31.9) | 31.2 (30.8 to 31.6) | 0.15 (-0.47 to 0.77) | 0.629 |