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Table 2 Means (and 95% CI:s) of metabolic parameters for subjects who completed the study. Mean differences between groups were obtained with analyses of covariance with the baseline value as a covariate. Means at three and six months are estimated marginal means. GHbA1c = glycosylated haemoglobin A1c.

From: Quality of life and metabolic status in mildly depressed patients with type 2 diabetes treated with paroxetine: A double-blind randomised placebo controlled 6-month trial

  Placebo (n = 14) Paroxetine (n = 23) Placebo – Paroxetine  
  Mean (95% CI) Mean (95% CI) Mean difference (95% CI) p
GHbA1c (%)     
   Baseline 9.0 (8.2 to 9.8) 8.5 (8.0 to 8.9) 0.54 (-0.24 to 1.31) 0.169
   3 months 8.5 (8.2 to 8.9) 7.9 (7.6 to 8.2) 0.59 (0.11 to 1.07) 0.018
   6 months 8.4 (7.9 to 8.9) 8.3 (7.9 to 8.7) 0.13 (-0.52 to 0.78) 0.693
Serum glucose (mmol/l)     
   Baseline 10.7 (8.6 to 12.8) 10.4 (8.8 to 12.0) 0.27 (-2.27 to 2.81) 0.829
   3 months 10.7 (9.8 to 12.5) 9.7 (8.2 to 11.1) 1.05 (-1.26 to 3.35) 0.362
   6 months 10.8 (9.1 to 12.5) 10.2 (8.8 to 11.5) 0.59 (-1.56 to 2.74) 0.580
Serum C-peptide (nmol/l)     
   Baseline 0.6 (0.3 to 0.8) 0.7 (0.5 to 0.9) -0.15 (-0.46 to 0.15) 0.310
   3 months 0.8 (0.6 to 0.9) 0.8 (0.7 to 1.0) -0.04 (-0.25 to 0.16) 0.656
   6 months 0.7 (0.6 to 0.9) 0.8 (0.7 to 0.9) -0.04 (-0.21 to 0.14) 0.682
Body mass index (kg/m2)     
   Baseline 31.1 (29.3 to 34.1) 31.7 (29.8 to 33.1) -0.66 (-4.14 to 2.82) 0.704
   3 months 31.1 (30.7 to 31.6) 31.0 (30.6 to 31.3) 0.15 (-0.44 to 0.73) 0.614
   6 months 31.4 (30.9 to 31.9) 31.2 (30.8 to 31.6) 0.15 (-0.47 to 0.77) 0.629