Table 3 Effect of statin according to initial concentration of total cholesterol. Most commonly used dose in the trials.
Weighted mean change from baseline | |||||
|---|---|---|---|---|---|
Number of trials | Number of patients | Initial [TC]* | Weighted mean initial [TC]* | Absolute | Percent |
Cerivastatin 0.4 mg | |||||
2 | 527 | All combined | 7.0 | -1.7 | -25 |
1 | 332 | 6.0–6.9 | 6.8 | -1.8 | -26 |
1 | 195 | 7.0–7.9 | 7.2 | -1.7 | -24 |
Fluvastatin 40 mg | |||||
5 | 376 | All combined | 7.6 | -1.3 | -17 |
1 | 25 | 6.0–6.9 | 6.4 | -0.8 | -12 |
3 | 287 | 7.0–7.9 | 7.4 | -1.3 | -18 |
1 | 40 | 9.0–9.9 | 9.1 | -1.6 | -17 |
Lovastatin 40 mg | |||||
7 | 3743 | All combined | 6.8 | -1.5 | -23 |
2 | 3436 | 6.0–6.9 | 6.7 | -1.5 | -23 |
1 | 211 | 7.0–7.9 | 7.0 | -1.4 | -20 |
1 | 96 | 9.0–9.9 | 9.6 | -2.1 | -22 |
Pravastatin 40 mg | |||||
17 | 6635 | All combined | 6.5 | -1.3 | -20 |
2 | 261 | 5.0–5.9 | 5.4 | -1.1 | -20 |
8 | 2315 | 6.0–6.9 | 6.2 | -1.1 | -18 |
6 | 3866 | 7.0–7.9 | 7.1 | -1.4 | -20 |
1 | 193 | 9.0–9.9 | 9.2 | -2.1 | -23 |
Simvastatin 40 mg | |||||
4 | 10952 | All combined | 5.7 | -1.5 | -26 |
1 | 10269 | 5.0–5.9 | 5.6 | -1.5 | -26 |
1 | 41 | 6.0–6.9 | 6.7 | -1.8 | -27 |
1 | 206 | 7.0–7.9 | 7.0 | -1.9 | -28 |
1 | 436 | 8.0–8.9 | 8.1 | -2.5 | -31 |