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Table 3 Number and proportions of patients who used two or more antihypertensive drugs concurrently and adjusted odds ratios for change

From: Change in antihypertensive drug prescribing after guideline implementation: a controlled before and after study

  Intervention Controls Intergroup comparison
  2001 2003 Adjusted* OR (95% CI) p-value 2001 2003 Adjusted* OR (95% CI) p-value Adjusted* OR (95% CI) p-value
  n (%)    n (%)     
Hypertension          
  828 (36.8) 1164 (39.2) 1.12 (0.99, 1.25) 0.06 2119 (38.5) 2774 (41.3) 1.13 (1.05, 1.21) 0.002 0.99 (0.86, 1.13) 0.86
CHD          
  110 (34.4) 164 (37.3) 1.19 (0.87, 1.62) 0.23 292 (30.7) 389 (33.9) 1.10 (0.91, 1.33) 0.33 1.07 (0.75, 1.54) 0.70
Diabetes          
  144 (47.7) 250 (54.8) 1.33 (0.99, 1.79) 0.06 303 (49.5) 428 (51.7) 1.10 (0.89, 1.36) 0.38 1.22 (0.85, 1.75) 0.28
  1. Prescription data was drawn from the national Prescription Register during a three-month period in 2001 and 2003.
  2. Abbreviations: CHD, coronary heart disease; OR, Odds ratio; CI, confidence interval.
  3. *Within-group analysis: Logistic regression, random effects model (physician as a random effect). Adjusted for patient's age and patient's sex. Reference group: patients with one antihypertensive drug.
  4. **Intergroup analysis: Logistic regression, random effects model (physician as a random effect). A product term between time (after versus before) and group (intervention versus control) was added in the model. Adjusted for patient's age and patient's sex. Reference group: patients with one antihypertensive drug.