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Table 8 Diagnostic performance of the 4DSQ and HADS anxiety scales with respect to detecting panic disorder, agoraphobia and social phobia (prevalence 19%)*

From: Detecting depressive and anxiety disorders in distressed patients in primary care; comparative diagnostic accuracy of the Four-Dimensional Symptom Questionnaire (4DSQ) and the Hospital Anxiety and Depression Scale (HADS)

4DSQ anxiety sensitivity specificity PPV NPV
≥4 0.98 0.53 0.33 0.99
≥5 0.89 0.61 0.35 0.96
≥6 0.86 0.68 0.39 0.95
≥7 0.82 0.73 0.42 0.95
≥8 0.79 0.78 0.46 0.94
≥9 0.71 0.82 0.49 0.92
≥10 0.64 0.85 0.49 0.91
≥11 0.54 0.89 0.53 0.89
≥12 0.43 0.91 0.53 0.87
≥13 0.32 0.93 0.50 0.85
≥14 0.27 0.94 0.50 0.85
≥15 0.23 0.96 0.56 0.84
HADS anxiety     
≥8 1.00 0.23 0.23 1.00
≥9 1.00 0.29 0.25 1.00
≥10 0.95 0.38 0.26 0.97
≥11 0.86 0.45 0.27 0.93
≥12 0.80 0.56 0.30 0.92
≥13 0.68 0.65 0.31 0.90
≥14 0.63 0.73 0.35 0.89
≥15 0.57 0.80 0.40 0.89
≥16 0.41 0.87 0.43 0.86
≥17 0.27 0.92 0.44 0.84
≥18 0.20 0.96 0.52 0.84
  1. * For each scale three cut-off points are highlighted in bold type: the optimal cut-off point with the best balance between sensitivity and specificity, the best lower cut-off point with a sensitivity ≥0.85, and the best higher cut-off point with a specificity ≥0.85
  2. 4DSQ = Four-Dimensional Symptom Questionnaire
  3. HADS = Hospital Anxiety and Depression Scale
  4. PPV = positive predictive value
  5. NPV = negative predictive value