From: Anti-hypertensive drugs deprescribing: an updated systematic review of clinical trials
Component | Description |
---|---|
Review question | What is the clinical- and cost-effectiveness of stopping antihypertensive treatment? |
Area of scope | Effects of stopping treatment |
Objective: | To evaluate the risks and benefits of stopping antihypertensive therapy to inform a recommendation |
Population | People taking antihypertensive drugs as primary or secondary prevention for at least 1 year |
Intervention | Stopping anti-hypertensive agents (thiazides, beta blockers, alpha blockers, calcium-channel blockers, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers) |
Comparison | Continuing anti hypertension agents |
Outcomes | Critical: • All-cause mortality • Cardiovascular mortality • Non-fatal myocardial infarction • Stroke • Quality of life • Hospitalization • Admission to care facility Important: • Blood pressure • Falls |
Study design | RCTs and systematic reviews of RCTs |
Exclusion | Pregnant women taking anti-hypertensives for secondary prevention Drugs used for other indications Duration of treatment less than 1 year |