Improving patient self-reporting of antihypertensive adverse drug events in primary care: a stepped wedge cluster randomised trial

Table 4 Characteristics of patients at inclusion (N = 1095)

	Control (N = 549)	Intervention (N = 546)	*p-value*
Age, mean (SD)	64.7 (11.8)	63.2 (11.3)	0.03
Male, % (n)	51.7 (284)	54.6 (298)	0.35
Educational level^a, % (n)			0.03
Secondary school or no diploma	40.7 (208)	33.4 (164)
Vocational/High-school degree	38.8 (198)	40.3 (198)
University degree	20.6 (105)	26.3 (129)
Socio-professional category^a, % (n)			0.09
Farmers, artisans, shopkeepers, CEOs	11.0 (56)	11.8 (58)
Executives, intellectuals, and intermediate professions	30.3 (155)	35.6 (175)
Employees and workers	53.2 (272)	49.5 (243)
Unemployed, retired, students	5.5 (28)	3.1 (15)
Morbidity ≥3 chronic pathologies ^a, % (n)	8.6 (44)	6.8 (34)	0.28
Situations with a risk of ADEs ^a, % (n)	8.5 (46)	15.4 (82)	< 0.001
Medications ≥4^a, % (n)	54.8 (301)	49.6 (271)	0.09
mean (± SD)	4.3 (2.8)	4.2 (3.0)	0.09
Antihypertensive classes ≥2^a, % (n)	63.8 (350)	55.5 (303)	0.01
mean (± SD)	2.0 (0.9)	1.8 (0.9)	0.01
Antihypertensive prescription^a, % (n)			0.16
Renewal	89.2 (487)	85.4 (462)
Modification	7.0 (38)	9.8 (53)
Initiation	3.9 (21)	4.8 (26)

SD standard deviation, ADE adverse drug event
Chronic pathologies: heart failure, heart rhythm disorder, anchor, myocardial infarction, obliterating arteriopathy of the lower limbs, renal artery stenosis, diabetes, cerebrovascular accident, COPD or chronic respiratory failure, asthma, cirrhosis or liver failure, renal failure (creatinine clearance < 60 ml/min), gout, cancer, depression, Parkinson
Situations presenting a risk of antihypertensive drug-related ADEs: hypotension, fever, nutritional depletion, diarrhoea, nausea, vomiting, abdominal pain, heat wave, reduced mobility, recent faint or fall (within the month before inclusion)
^aCharacteristics are described on available data. Missing data concerned less than 8.5% of patients

ISSN: 2731-4553