Table 1 Clinical manifestations of ATTRv and ATTRwt amyloidosis

Age at symptom onset

> 20 years

> 50 years

[8,9,10,11,12]

Male, %

76–86

91–97

[13,14,15]

Duration of symptoms before diagnosis

~ 3 years

~ 2 years

[8, 9, 11]

Median life expectancy, after diagnosis

• 2–5 years with predominantly CM

• 8–10 years with predominantly PN

4 years

[9, 12, 16, 17]

Cardiac

Yes

Yes

[13, 18, 19]

Peripheral nerves

Yes

Occasionally

[13, 18]

Autonomic nerves (including gastrointestinal)

Yes

Rare

[13, 18, 20, 21]

Kidney

Yes

Rare

[1, 13]

Ophthalmologic

Vitreous deposition

Not prominent

[1]

Musculoskeletal

Yes

Yes

[13, 22,23,24,25,26,27,28]