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Table 1 Laboratory-orientated etiologies of anemia

From: A new diagnostic work-up for defining anemia etiologies: a cohort study in patients ≥ 50 years in general practices

  Definition
Anemia of chronic disease Serum ferritin > 100 μg/L and at least one of the following transferrin ≤3.60 g/L or iron < 14 (male) / < 10 (female) μmol/L
Renal anemia Estimated glomerular filtration rate < 45 mL/min/1.73m2
Iron deficiency anemia Serum ferritin < 25 (male) or < 20 (female) μg/L
Hemoglobinopathy Hemoglobin electrophoresis was conducted in case of low MCV (< 80 fl) in combination with increased erythrocyte count (> 6.2 (male) or > 5.4 (female) μl) (and followed by genetic testing).
Suspected hemolysis Lactate dehydrogenase > 241 U/L and reticulocytes > 2.5%
Suspected bone marrow disease Reticulocytes < 2.5% and leukocyte count < 4.3 or > 10 109/L and thrombocyte count < 150 / > 390 109/L
Vitamin B12 deficiency Serum vitamin B12 < 130 pmol/L
Folic acid deficiency Serum folic acid < 5 nmol/L
Multiple causes Satisfied more than one of the above definitions
Uncertain Satisfied none of the above definitions