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Anemia of chronic disease
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Serum ferritin > 100 μg/L and at least one of the following transferrin ≤3.60 g/L or iron < 14 (male) / < 10 (female) μmol/L
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Renal anemia
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Estimated glomerular filtration rate < 45 mL/min/1.73m2
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Iron deficiency anemia
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Serum ferritin < 25 (male) or < 20 (female) μg/L
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Hemoglobinopathy
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Hemoglobin electrophoresis was conducted in case of low MCV (< 80 fl) in combination with increased erythrocyte count (> 6.2 (male) or > 5.4 (female) μl) (and followed by genetic testing).
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Suspected hemolysis
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Lactate dehydrogenase > 241 U/L and reticulocytes > 2.5%
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Suspected bone marrow disease
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Reticulocytes < 2.5% and leukocyte count < 4.3 or > 10 109/L and thrombocyte count < 150 / > 390 109/L
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Vitamin B12 deficiency
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Serum vitamin B12 < 130 pmol/L
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Folic acid deficiency
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Serum folic acid < 5 nmol/L
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Multiple causes
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Satisfied more than one of the above definitions
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Uncertain
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Satisfied none of the above definitions
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