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Table 3 Patient and clinic determinants of HbA1c, SBP and LDL-C levels in T2D

From: Clinic and patient variation in intermediate clinical outcomes for type 2 diabetes: a multilevel analysis

Fixed effects

HbA1c

SBP

LDL-C

Coefficient (95% CI)

p-value

Coefficient (95% CI)

p-value

Coefficient (95% CI)

p-value

Patient level

 Age (years)

− 0.04(− 0.05, − 0.03))

***

0.08(0.01, 0.15)

*

− 0.007(− 0.01, − 0.003)

**

 Male sex

− 0.04(− 0.19, 0.10)

 

−1.92(−3.22, − 0.63)

**

− 0.05(− 0.12, 0.03)

 

 Malay ethnicity

0.01(− 0.15, 0.18)

 

1.85(0.35, 3.35)

*

0.27(0.18, 0.36)

***

 Duration of diabetes (years)

0.05(0.04, 0.07)

***

− 0.09(− 0.21, 0.04)

 

− 0.01(− 0.02, − 0.003)

**

 Body mass index

0.004(− 0.01, 0.02)

 

0.06(− 0.06, 0.17)

 

− 0.01(− 0.02, − 0.004)

**

 HbA1c

–

 

−0.22(− 0.54, 0.11)

 

0.07(0.05, 0.09)

***

 SBP

− 0.005(− 0.009, − 0.001)

**

–

 

0.002(0.0001, 0.004)

*

 LDL-C

0.23(0.16, 0.29)

***

0.67(0.07, 1.26)

*

–

 

 Hypertension

–

 

2.64(0.85, 4.43)

**

–

 

 Hyperlipidaemia

–

 

–

 

0.04(−0.04, 0.13)

 

 Microvascular complication

0.21(0.03, 0.38)

*

1.79(0.19, 3.38)

*

−0.10(− 0.19, − 0.0001)

 

 Macrovascular complication

− 0.07(− 0.34, 0.20)

 

−1.23(−3.64, 1.18)

 

−0.14(− 0.28, 0.01)

 

 Insulin

1.81(1.65, 1.98)

***

0.25(−1.31, 1.81)

 

−0.01(− 0.11, 0.08)

 

 Number of antihypertensive(s)

–

 

4.43(3.76, 5.10)

***

0.03(−0.01, 0.07)

 

 ACEI/ARB

0.05(−0.10, 0.20)

 

–

 

–

 

 Statin

−0.06(− 0.24, 0.12)

 

−2.56(−4.17, − 0.29)

**

−0.01(− 0.11, 0.09)

 

Clinic level

 Urban geographical location

−0.11(− 0.41, 0.19)

 

−3.03(−7.12, 1.05)

 

0.04(− 0.12, 0.19)

 

 Daily attendances

−0.0003(− 0.001, 0.001)

 

0.01(− 0.01, 0.02)

 

0.00003(− 0.0004, 0.0005)

 

 Family medicine specialist available

−0.05(− 0.40, 0.30)

 

− 0.41(−5.20, 4.39)

 

−0.04(− 0.23, 0.14)

 

 Diabetes educator available

−0.15(− 0.41, 0.12)

 

0.03(−3.68, 3.73)

 

− 0.04(− 0.18, 0.10)

 

 Diabetes medication adherence service available

− 0.04(− 0.40, 0.33)

 

2.04(−2.99, 7.07)

 

−0.13(− 0.33, 0.06)

 

Goodness of fit

 Deviancea

12,242

 

25,193

 

8551

 

 Deviance change from empty model

− 900

 

− 384

 

− 148

 
  1. *p < 0.05, **p < 0.01, ***p < 0.001
  2. ACEI angiotensin-converting enzyme inhibitor, ARB angiotensin-II receptor blocker, CI confidence interval, HbA1c glycated haemoglobin, LDL-C low-density lipoprotein cholesterol, SBP systolic blood pressure, T2D type 2 diabetes
  3. aDecrease in ‘deviance’ reflects improvement in goodness of fit of the final model compared to the empty model. Change in deviance with each consecutive model were shown in the Additional file: Table