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Table 4 Adverse drug reactions attributed to warfarin at our Institution

From: Standardized warfarin monitoring decreases adverse drug reactions

Metric

2013 (Baseline)

2014

2015

2016

2017

P-value

Number of severe warfarin ADRs

63/1658

37/2073

54/2294

28/2247

26/2650

 

Warfarin ADR rate

3.80%

1.78%

2.35%

1.25%

0.98%

p < 0.0001

  1. ADR Adverse drug reaction, Severe ADR: death, life-threatening (real risk of dying), hospitalization (initial or prolonged), disability (significant, persistent, or permanent), congenital anomaly, or requiring intervention to prevent permanent impairment or damage