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Table 4 Most frequently changed drugs

From: Changes in prescribed medicines in older patients with multimorbidity and polypharmacy in general practice

Interval Δ1 (baseline to 6 month follow-up) Interval Δ2 (6-month follow-up to 9-month follow-up)
Intervention group Control group Intervention group Control group
Drug Changes in Δ1 / total prescriptions at T0a
(n / N, %)
Drug Changes in Δ1 / total prescriptions at T0a
(n / N, %)
Drug Changes in Δ2 / total prescriptions at T1a
(n / N, %)
Drug Changes in Δ2 / total prescriptions at T1a
(n / N, %)
Simvastatin 75 / 104 (72%) Simvastatin 90 / 128 (70%) Aspirin* 40 / 108 (37%) Simvastatin 72 / 121 (60%)
Ramipril 70 / 67 (104%) Aspirin* 58 / 126 (46%) Omeprazole 39 / 48 (81%) Aspirin* 50 / 122 (41%)
Metformin 63 / 61 (103%) Metformin 49 / 57 (86%) Simvastatin 38 / 107 (35%) Metformin 39 / 50 (78%)
Amlodipine 63 / 76 (83%) Allopurinol 43 / 47 (91%) Ramipril 37 / 64 (56%) Omeprazole 34 / 52 (65%)
Metoprolol* 59 / 69 (85%) Amlodipine 40 / 57 (70%) Metformin 34 / 60 (57%) Torasemide 33 / 50 (66%)
Bisoprolol 58 / 62 (93%) Pantoprazole 39 / 33 (118%) Torasemide 34 / 57 (60%) Metoprolol* 31 / 49 (63%)
Omeprazole 54 / 55 (98%) Bisoprolol 39 / 65 (60%) Pantoprazole 29 / 31 (93%) Ramipril 29 / 58 (50%)
Aspirin* 53 / 105 (50%) Metoprolol* 38 / 54 (70%) Allopurinol 28 / 44 (64%) Pantoprazole 28 / 29 (96%)
Torasemide 45 / 52 (87%) Ramipril 38 / 54 (70%) Metoprolol* 27 / 67 (40%) Amlodipine 25 / 53 (47%)
Allopurinol 45 / 53 (85%) Omeprazole 37 / 50 (74%) Amlodipine 25 / 70 (36%) Bisoprolol 24 / 62 (39%)
Levothyroxine 40 / 55 (73%) Torasemide 37 / 55 (67%) Bisoprolol 18 / 63 (29%) Allopurinol 23 / 44 (52%)
Pantoprazole 37 / 30 (123%) HCT 24 / 40 (60%) Diclofenac 17 / 34 (50%) Diclofenac 22 / 12 (183%)
Diclofenac 33 / 36 (92%) Levothyroxine 23 / 55 (42%) Ca + D3 16 / 14 (114%) HCT 20 / 37 (54%)
  1. number of changed prescriptions during the interval per number of prescriptions at the begin of the interval, percentages > 100% indicate prescriptions with more than one change during the interval under investigation. API – active pharmaceutical ingredient, Aspirin* - low dose aspirin, Ca + D3 – combination of calcium and cholecalciferol (vitamin D3), HCT – hydrochlorothiazide, Metoprolol* - metoprolol-succinate