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Table 3 Rates (95% CI) of all symptoms and of fatigue symptoms and rate ratios (95% CI) from 15 years before (adults) or 10 years before (paediatric) until 10 years after a first recorded diagnosis of CFS/ME

From: Health care resource use by patients before and after a diagnosis of chronic fatigue syndrome (CFS/ME): a clinical practice research datalink study

 

Year −15 to −11

Year −10 to −6

Year −5 to −1

Year 0

Year 1 to 5

Year 6 to 10

Total adult person years

 Cases

4579

12,183

24,478

6710

25,447

10,815

 Controls

4649

12,258

24,564

6710

25,038

10, 508

Adults (all symptoms)

 Cases (rate per patient year)

1.14 (1.11, 1.17)

1.53 (1.51, 1.55)

2.46 (2.44, 2.48)

3.19 (3.15, 3.23)

2.35 (2.33, 2.37)

2.40 (2.37, 2.43)

 Controls (rate per patient year)

0.67 (0.65, 0.70)

0.98 (0.96, 1.00)

1.30 (1.29, 1.32)

1.36 (1.34, 1.39)

1.41 (1.40, 1.43)

1.55 (1.53, 1.57)

 Rate ratio

1.69 (1.62, 1.77)

1.57 (1.53, 1.60)

1.89 (1.87, 1.92)

2.34 (2.28, 2.39)

1.67 (1.65, 1.69)

1.55 (1.52, 1.58)

Adults (fatigue symptoms)

 Cases (rate per patient year)

2.80 (2.31, 3.28)

6.15 (5.71, 6.59)

19.4 (18.9, 20.0)

57.5 (55.7, 59.3)

10.9 (10.5, 11.3)

8.61 (8.06, 9.16)

 Controls (rate per patient year)

0.34 (0.18, 0.51)

1.61 (1.38, 1.83)

2.31 (2.12, 2.50)

2.62 (2.24, 3.01)

2.66 (2.45, 2.86)

2.29 (2.00, 2.58)

 Rate ratio

8.12 (4.83, 13.7)

3.83 (3.27, 4.48)

8.40 (7.70, 9.16)

21.9 (18.8, 25.5)

4.10 (3.77, 4.46)

3.75 (3.26, 4.32)

Total paediatric person years

 Cases

 

2088

3715

916

3290

1076

 Controls

 

1996

3591

916

3257

1077

Paediatric (all symptoms)

 Cases (rate per 100 patient years)

 

1.14 (1.10, 1.19)

1.74 (1.70, 1.78)

3.12 (3.01, 3.24)

1.62 (1.58, 1.66)

1.53 (1.46, 1.61)

 Controls (rate per 100 patient years)

 

0.68 (0.64, 0.72)

0.67 (0.64, 0.69)

0.71 (0.66, 0.76)

0.81 (0.78, 0.84)

0.86 (0.80, 0.91)

 Rate ratio

 

1.68 (1.57, 1.79)

2.60 (2.48, 2.73)

4.40 (4.04, 4.79)

2.00 (1.91, 2.10)

1.79 (1.65, 1.94)

Paediatric (fatigue symptoms)

 Cases (rate per 100 patient years)

 

1.39 (0.88, 1.89)

11.6 (10.5, 12.7)

56.3 (51.5, 61.2)

7.36 (6.43, 8.28)

4.83 (3.52, 6.15)

 Controls (rate per 100 patient years)

 

0.20 (0.00, 0.40)

0.56 (0.31, 0.80)

1.09 (0.42, 1.77)

1.81 (1.35, 2.27)

1.02 (0.42, 1.62)

 Rate ratio

 

6.93 (2.44, 19.7)

20.8 (13.3, 32.6)

51.6 (27.6, 96.5)

4.06 (3.05, 5.40)

4.73 (2.47, 9.07)

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