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Table 3 Rates (95% CI) of all symptoms and of fatigue symptoms and rate ratios (95% CI) from 15 years before (adults) or 10 years before (paediatric) until 10 years after a first recorded diagnosis of CFS/ME

From: Health care resource use by patients before and after a diagnosis of chronic fatigue syndrome (CFS/ME): a clinical practice research datalink study

  Year −15 to −11 Year −10 to −6 Year −5 to −1 Year 0 Year 1 to 5 Year 6 to 10
Total adult person years
 Cases 4579 12,183 24,478 6710 25,447 10,815
 Controls 4649 12,258 24,564 6710 25,038 10, 508
Adults (all symptoms)
 Cases (rate per patient year) 1.14 (1.11, 1.17) 1.53 (1.51, 1.55) 2.46 (2.44, 2.48) 3.19 (3.15, 3.23) 2.35 (2.33, 2.37) 2.40 (2.37, 2.43)
 Controls (rate per patient year) 0.67 (0.65, 0.70) 0.98 (0.96, 1.00) 1.30 (1.29, 1.32) 1.36 (1.34, 1.39) 1.41 (1.40, 1.43) 1.55 (1.53, 1.57)
 Rate ratio 1.69 (1.62, 1.77) 1.57 (1.53, 1.60) 1.89 (1.87, 1.92) 2.34 (2.28, 2.39) 1.67 (1.65, 1.69) 1.55 (1.52, 1.58)
Adults (fatigue symptoms)
 Cases (rate per patient year) 2.80 (2.31, 3.28) 6.15 (5.71, 6.59) 19.4 (18.9, 20.0) 57.5 (55.7, 59.3) 10.9 (10.5, 11.3) 8.61 (8.06, 9.16)
 Controls (rate per patient year) 0.34 (0.18, 0.51) 1.61 (1.38, 1.83) 2.31 (2.12, 2.50) 2.62 (2.24, 3.01) 2.66 (2.45, 2.86) 2.29 (2.00, 2.58)
 Rate ratio 8.12 (4.83, 13.7) 3.83 (3.27, 4.48) 8.40 (7.70, 9.16) 21.9 (18.8, 25.5) 4.10 (3.77, 4.46) 3.75 (3.26, 4.32)
Total paediatric person years
 Cases   2088 3715 916 3290 1076
 Controls   1996 3591 916 3257 1077
Paediatric (all symptoms)
 Cases (rate per 100 patient years)   1.14 (1.10, 1.19) 1.74 (1.70, 1.78) 3.12 (3.01, 3.24) 1.62 (1.58, 1.66) 1.53 (1.46, 1.61)
 Controls (rate per 100 patient years)   0.68 (0.64, 0.72) 0.67 (0.64, 0.69) 0.71 (0.66, 0.76) 0.81 (0.78, 0.84) 0.86 (0.80, 0.91)
 Rate ratio   1.68 (1.57, 1.79) 2.60 (2.48, 2.73) 4.40 (4.04, 4.79) 2.00 (1.91, 2.10) 1.79 (1.65, 1.94)
Paediatric (fatigue symptoms)
 Cases (rate per 100 patient years)   1.39 (0.88, 1.89) 11.6 (10.5, 12.7) 56.3 (51.5, 61.2) 7.36 (6.43, 8.28) 4.83 (3.52, 6.15)
 Controls (rate per 100 patient years)   0.20 (0.00, 0.40) 0.56 (0.31, 0.80) 1.09 (0.42, 1.77) 1.81 (1.35, 2.27) 1.02 (0.42, 1.62)
 Rate ratio   6.93 (2.44, 19.7) 20.8 (13.3, 32.6) 51.6 (27.6, 96.5) 4.06 (3.05, 5.40) 4.73 (2.47, 9.07)