Table 1 Rates per patient year (95% CI) and rate ratios (95% CI) of GP consultations, tests, prescriptions and referrals from 15 years before until 10 years after a first recorded diagnosis of CFS/ME in adult cases compared with controls

 Cases

4579

12,183

24,478

6710

25,447

10,815

 Controls

4649

12,258

24,564

6710

25,038

10, 508

 Cases (rate)

6.42 (6.35, 6.49)

6.77 (6.72, 6.81)

8.06 (8.02, 8.09)

10.6 (10.6, 10.7)

7.11 (7.08, 7.14)

6.59 (6.54, 6.64)

 Controls (rate)

4.31 (4.25, 4.37)

4.53 (4.49, 4.56)

4.58 (4.56, 4.61)

4.29 (4.24, 4.34)

4.10 (4.07, 4.12)

4.24 (4.20, 4.28)

 Rate ratio

1.49 (1.46, 1.52)

1.50 (1.48, 1.51)

1.76 (1.75, 1.77)

2.48 (2.44, 2.51)

1.73 (1.72, 1.75)

1.56 (1.54, 1.57)

 Cases (rate)

2.50 (2.46, 2.55)

8.01 (7.96, 8.06)

20.4 (20.3, 20.4)

37.0 (36.9, 37.2)

23.1 (23.0, 23.1)

26.4 (26.3, 26.5)

 Controls (rate)

1.53 (1.49, 1.57)

4.98 (4.94, 5.02)

9.75 (9.71, 9.79)

12.3 (12.2, 12.3)

14.2 (14.1, 14.2)

17.6 (17.5, 17.7)

 Rate ratio

1.64 (1.59, 1.68)

1.61 (1.59, 1.62)

2.09 (2.08, 2.10)

3.02 (3.00, 3.05)

1.63 (1.62, 1.64)

1.50 (1.49, 1.51)

 Cases (rate)

6.83 (6.76, 6.91)

6.26 (6.21, 6.30)

6.63 (6.60, 6.67)

7.84 (7.78, 7.91)

6.48 (6.45, 6.51)

6.63 (6.58, 6.68)

 Controls (rate)

4.39 (4.33, 4.45)

3.84 (3.81, 3.88)

3.47 (3.45, 3.50)

3.34 (3.29, 3.38)

3.31 (3.29, 3.33)

3.59 (3.56, 3.63)

 Rate ratio

1.56 (1.53, 1.58)

1.63 (1.61, 1.65)

1.91 (1.89, 1.93)

2.35 (2.31, 2.39)

1.96 (1.94, 1.98)

1.85 (1.82, 1.87)

 Cases (rate)

0.99 (0.96, 1.02)

0.86 (0.84, 0.87)

0.86 (0.85, 0.87)

1.38 (1.35, 1.41)

0.76 (0.75, 0.77)

0.71 (0.70, 0.73)

 Controls (rate)

0.65 (0.63, 0.67)

0.55 (0.54, 0.57)

0.43 (0.42, 0.43)

0.39 (0.37, 0.40)

0.38 (0.37, 0.39)

0.40 (0.39, 0.41)

 Rate ratio

1.53 (1.46, 1.60)

1.55 (1.50, 1.60)

2.02 (1.98, 2.07)

3.54 (3.39, 3.70)

2.00 (1.95, 2.05)

1.78 (1.72, 1.85)