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Table 1 Definitions of the different causes found in the macrocytic cohort

From: Prevalence of potential underlying aetiology of macrocytic anaemia in Dutch general practice

Cause Definition
1) Vitamin B12 deficiency Vitamin B12 < 130 pmol/L
2) Folic acid deficiency Folic acid < 5 nmol/L
3) Possible bone marrow disease Abnormal number leukocytes and thrombocytes Reticulocytes < 2.5 %
4) Haemolysis Raised LDH, reticulocytes > 2.5 %, bilirubin > 17 μmol/L
5) Documented alcohol abuse Documented in patient file by treating physician
6) Anaemia of chronic disease (ACD) Ferritin > 100 μg/L, serum transferrin < 2.0 g/L and/or serum iron < 14 μmol/L (men), < 10 μmol/L (women)
7) Iron deficiency anaemia (IDA) Ferritin < 25 μg/L (men), < 20 μg/L (women)
8) Renal anaemia Estimated creatinine clearance (MDRD) ≤ 45 mL/min/1.73 m2 (8)
9) Other Documented in patient file by treating physician
10) Unknown No cause could be determined
  1. These cut-off values were derived from the reference intervals used in the Clinical Chemistry laboratory of the Albert Schweitzer Hospital where all tests were conducted