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Table 3 Example of process for assigning the reference standard

From: Towards improving diagnosis of memory loss in general practice: TIMeLi diagnostic test accuracy study protocol

Assessor

AB

MF

SJC

Role

Consultant geriatrician with interest in memory disorders

Consultant neurologist

Consultant old age psychiatrist

Study ID

XX1

XX1

XX1

Status: Dementia/major neurocognitive disorder DSM 5 or MCI [19]/mild neurocognitive disorder DSM 5 or Normal

DSMa IV [12]

Dementia

Dementia

Dementia

DSMa 5 [13]

Major neurocognitive disorder

Mild neurocognitive disorder

Major neurocognitive disorder

ICD 10b [11]

MCI

Dementia

Dementia

Overall

Dementia

Dementia

Dementia

Consensus judgement

Dementia

Aetiological subtype

Alzheimer’s disease probable [6]

X

 

X

Alzheimer’s disease possible [6]

 

X

 

Ischaemic cerebrovascular disease dementia probable [7]

   

Ischaemic cerebrovascular disease dementia possible [7]

   

Mixed aetiology [13]

   

Parkinson’s [13]

   

Lewy Body Dementia probable [8, 9, 13]

   

Lewy Body Dementia possible [8, 9, 13]

   

Tauopathy/Frontotemporal dementia [10]

   

Other (describe) [13]

   

Uncertain [13]

   

Consensus judgement

Alzheimer’s disease probable [6]

  1. Notes: For the main analysis participant XX1 would be classed as having dementia
  2. aDiagnostic and statistical manual of mental disorders/
  3. bInternational classification of diseases