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Table 2 Diagnostic accuracy of geriatric screening tools to predict decline in functional status and QoL

From: Geriatric screening tools are of limited value to predict decline in functional status and quality of life: results of a cohort study

   

Sensitivity

Specificity

Positive predictive value

Negative predictive value

Area under the curve

Univariate logistic regression

Multivariate logistic regressionc

  

N total

Se

(95% CI)

Sp

(95% CI)

PPV

(95% CI)

NPV

(95% CI)

AUC

(95% CI)

OR

(95% CI)

OR

(95% CI)

Functional decline a

                

aCGA

Cancer patients

115

71%

(59% - 82%)

33%

(20% - 48%)

59%

(47% - 70%)

46%

(29% - 63%)

0.52

(0.43 - 0.61)

1.20

(0.54 - 2.67)

0.61

(0.23 - 1.64)

 

Persons without cancer

187

67%

(55% - 78%)

52%

(43% - 62%)

49%

(39% - 59%)

70%

(59% - 80%)

0.60

(0.53 - 0.67)

2.23

(1.22 - 4.09)

1.87

(0.93 - 3.78)

G8

Cancer patients

115

64%

(51% - 75%)

37%

(23% - 52%)

58%

(45% - 69%)

43%

(28% - 59%)

0.50

(0.41 - 0.59)

1.02

(0.47 - 2.19)

0.67

(0.28 - 1.65)

 

Persons without cancer

187

65%

(53% - 75%)

57%

(47% - 66%)

51%

(40% - 61%)

70%

(59% - 79%)

0.61

(0.54 - 0.68)

2.38

(1.31 - 4.35)

1.80

(0.90 - 3.60)

GFI

Cancer patients

67

54%

(37% - 71%)

59%

(41% - 76%)

59%

(41% - 76%)

54%

(37% - 71%)

0.57

(0.45 - 0.69)

1.74

(0.66 - 4.58)

1.23

(0.35 - 4.35)

 

Persons without cancer

187

58%

(46% - 69%)

63%

(53% - 72%)

52%

(41% - 63%)

69%

(59% - 78%)

0.61

(0.53 - 0.68)

2.35

(1.29 - 4.26)

1.83

(0.92 - 3.65)

VES-13

Cancer patients

67

57%

(39% - 74%)

66%

(47% - 81%)

65%

(45% - 81%)

58%

(41% - 75%)

0.61

(0.50 - 0.73)

2.55

(0.95 - 6.85)

2.58

(0.59 - 11.22)

 

Persons without cancer

187

62%

(50% - 73%)

66%

(56% - 75%)

55%

(44% - 66%)

72%

(62% - 80%)

0.64

(0.57 - 0.71)

3.11

(1.70 - 5.71)

2.83

(1.35 - 5.95)

Decline in Qol b

                

aCGA

Cancer patients

67

47%

(21% - 73%)

37%

(24% - 51%)

18%

(7% - 33%)

70%

(50% - 86%)

0.42

(0.27 - 0.56)

0.50

(0.16 - 1.61)

0.44

(0.10 - 1.91)

 

Persons without cancer

187

56%

(41% - 70%)

45%

(36% - 53%)

27%

(19% - 37%)

74%

(63% - 83%)

0.50

(0.42 - 0.58)

1.02

(0.53 - 1.96)

1.14

(0.55 - 2.39)

G8

Cancer patients

67

67%

(38% - 88%)

39%

(25% - 53%)

24%

(12% - 40%)

80%

(59% - 93%)

0.53

(0.39 - 0.67)

1.25

(0.37 - 4.19)

1.47

(0.36 - 6.05)

 

Persons without cancer

187

40%

(26% - 55%)

44%

(35% - 53%)

21%

(13% - 30%)

67%

(56% - 76%)

0.42

(0.34 - 0.50)

0.52

(0.27 - 1.00)

0.48

(0.22 - 1.03)

GFI

Cancer patients

67

40%

(16% - 68%)

50%

(36% - 64%)

19%

(7% - 36%)

74%

(57% - 88%)

0.45

(0.30 - 0.60)

0.67

(0.21 - 2.14)

0.50

(0.11 - 2.20)

 

Persons without cancer

187

42%

(28% - 57%)

53%

(45% - 62%)

25%

(16% - 35%)

72%

(62% - 80%)

0.48

(0.40 - 0.56)

0.83

(0.43 - 1.59)

0.89

(0.42 - 1.88)

VES-13

Cancer patients

67

47%

(21% - 73%)

54%

(40% - 68%)

23%

(10% - 41%)

78%

(61% - 90%)

0.50

(0.36 - 0.65)

1.02

(0.32 - 3.23)

0.53

(0.10 - 2.83)

 

Persons without cancer

187

42%

(28% - 57%)

53%

(45% - 62%)

25%

(16% - 35%)

72%

(62% - 80%)

0.48

(0.40 - 0.56)

0.83

(0.43 - 1.59)

0.88

(0.40 - 1.92)

  1. Significant OR’s were indicated in bold.
  2. Abbreviations: QoL Quality of Life, aCGA abbreviated Comprehensive Geriatric Assessment, GFI Groningen Frailty Indicator, VES-13 Vulnerable Elders Survey-13, Se sensitivity, Sp specificity, PPV positive predictive value, NPV negative predictive value, OR odds ratio, 95% CI 95% confidence interval.
  3. aFunctional decline was defined as deterioration one or more domains of ADL and/or IADL compared to baseline.
  4. bDecline in QoL was defined as a difference of ≥ 10 points.
  5. cMultivariate logistic regression: adjusted for age, gender, and number of medicines. For cancer patients we also adjusted for stage, type of cancer, and type of treatment.