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Table 4 Results of Cox proportional hazards model for therapy discontinuation

From: Improved persistence and adherence to diuretic fixed-dose combination therapy compared to diuretic monotherapy

 

Study population (N = 48,212)

Variable

Hazards ratio

p-value

Age

0.989

<.0001*

Female

1.048

0.0002*

RxRisk categoriesa

  

   Anxiety and Tension, Bipolar Disorder, Depression, Psychotic Illness, ADD

1.079

<.0001*

   Asthma, Allergic Rhinitis

1.031

0.1891

   Cardiac Disease, Coronary & Peripheral Vascular Disease, Heart Disease, Hypertensionb

0.973

0.2432

   Gastric acid disorder, IBS

1.004

0.8477

   Rheumatoid Arthritis, Gout

1.147

<.0001*

   Thyroid Disease

0.951

0.0426*

   Diabetes

1.158

<.0001*

Business Type

  

   HMO

N/A

N/A

   Medicaid

1.339

<.0001*

   Medicare

1.451

<.0001*

   Self

1.056

0.0013*

Concomitant Other CVD-related Medications Used

  

   Digitalis

1.138

0.0086*

   Nitrates

1.224

<.0001*

   Antiplatelet Medications

1.097

0.0502

   Antihyperlipidemic Medications

0.797

<.0001*

Average copayc

1.001

0.3831

Target medication classesd

  

   ARB/HCTZ

0.529

<.0001*

   ACEI/HCTZ

0.536

<.0001*

   BB/HCTZ

0.532

<.0001*

  1. * Significant p-value
  2. a RxRisk categories shown in this table include the 7 most frequent disease states in the study cohort. All RxRisk disease categories were included in the model.
  3. b This RxRisk category does not include the target medications, digitalis, nitrates, antiplatelet medications or antihyperlipidemics.
  4. c Limited to HTN medications of the same class as the index drug.
  5. d Reference Medication Class = HCTZ
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