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Table 4 Results

From: Buprenorphine versus dihydrocodeine for opiate detoxification in primary care: a randomised controlled trial

 

Buprenorphine (total 28)

Dihydrocodeine (total 32)

Odds Ratio (95% CI)

Relative Risk (95% CI)

P value

By end of detox

   Final urine sample

9 (32%)

4 (13%)

3.32 (0.77–15.22)

1.71 (1.04–2.83)

0.065

   Non-ITT Clean urine

6/9 (67%)

1/4 (25%)

6.00 (0.28–246)

1.71 (0.73–4.03)

0.164

   ITT-1* clean urine

6/28 (21%)

1/32 (3%)

8.45 (0.89–200)

2.06 (1.33–3.21)

0.028

   ITT-2* clean urine

6+3/28

1+8/32

1.21 (0.35–4.21)

1.11 (0.63–1.95)

0.735

   Leaving early

19 (68%)

28 (88%)

0.30 (0.07–1.30)

0.58 (0.35–0.96)

0.065

   Overdose

0

0

Not applicable

   Inappropriate use of allocated drug

0

0

Not applicable

   A&E attendance

0

0

Not applicable

   Admitted

0

0

Not applicable

   Overdose

0

0

Not applicable

   GP visits – mean

2.2 (1.05)

2.8 (1.33)

  

0.06

   Drug worker visits – mean

0.17 (0.47)

1.31 (0.59)

  

0.343

At 3 months post detoxification

   Abstinent

10/27 (37%)

4/24 (17%)

2.94 (0.67–13.78)

1.55 (0.96–2.52)

0.104

   Dead

0/27

0/28

Not applicable

   On Med 3 sick note

10/16 (63%)

6/14 (43%)

2.22 (0.41–12.65)

1.46 (0.71–2.98)

0.282

   A&E attendance

2/27 (7%)

2/28 (7%)

1.04 (0.09–11.46)

1.06 (0.38–2.94)

0.970

   Hospital attendance

1/27 (4%)

2/28 (7%)

0.5 (0.02–7.75)

0.67 (0.13–3.38)

0.574

   GP visits – mean

5.04 (4.85)

4.61 (4.10)

  

0.724

   Drug worker visits – mean

1.22 (1.67)

1.14 (1.53)

  

0.855

At 6 months post detoxification

   Abstinent

7/22 (32%)

3/19 (16%)

2.49 (0.45–15.15)

1.45 (0.84–2.49)

0.233

   Dead

0/23

0/20

Not applicable

   On Med 3 sick note

3/11 (27%)

2/11 (18%)

1.69 (0.16–20.05)

1.27 (0.53–3.06)

0.611

   A&E attendance

0/22

0/20

Not applicable

   Hospital attendance

0/22

2/20 (10%)

0.16 (0.01–3.64)

 

0.129

   GP visits – mean

7.54 (6.71)

6.48 (6.07)

  

0.582

   Drug worker visits – mean

1.74 (2.40)

2.65 (2.89)

  

0.265

  1. • Assumption 1 = everybody not returning for final urine test had not clean urine
  2. • Assumption 2 = everybody not returning for final urine test had same proportion of not clean urine as those who did
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