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Table 7 Details of Abstracts (duplicates removed)

From: Inhaled ciclesonide versus inhaled budesonide or inhaled beclomethasone or inhaled fluticasone for chronic asthma in adults: a systematic review

Author Date Comparator Study size Reported characterists Duration Outcome Measures
Boulet et al 2003 CIC 400 mcg (mdi) od am
Vs.
BUD 400 mcg (turbo) od am
359 Randomized double blind multicenter 12 weeks parallel Lung function
FEV1
FVC
Symptoms
Change in symptoms
% symptom free days
use of rescue meds
Ukena et al 2003 CIC 400 mcg (mdi) od pm
Vs.
BUD 400 mcg (turbo) od pm
399 Randomized double blind multicenter 12 weeks parallel Lung function
FEV1
FVC,
Timing of onset of action
PEF
Symptoms
Change in symptoms
% symptom free days
use of rescue meds
HPA Suppression
Urine cortisol
Hansel et al 2003 CIC 100 mcg (mdi) od am
Vs.
CIC 400 mcg (mdi) od am
Vs.
BUD 200 mcg (turbo) bd
554 Randomized double blind multicenter 12 weeks parallel Lung function
FEV1
FVC
PEF
Symptoms
Change in symptoms
% symptom free days
use of rescue meds
HPA Suppression
Urine cortisol
Derom et al 2001 CIC 400 mcg od Vs. CIC 800 mcg od
Vs.
CIC 800 mcg bd
Vs.
FP 500 mcg bd
Vs.
FP 1000mcg bd
25 Randomized double blind
double dummy
placebo controlled
7 days
6 period crossover with at least 3 weeks washout period
Airway responsiveness to AMP
PC20 FEV1(doubling doses)
HPA Suppression
Plasma cortisol
Urinary cortisol excretion