Trial | Results CIC vs. comparator | ||||
---|---|---|---|---|---|
Lung Function | |||||
Lee, Fardon et al | Authors report no significant difference (CIC vs. FP) | ||||
Lee, Haggart et al | Â | 95% CI for CIC vs. FP | Â | Â | Â |
 | FEV1 (l) | -0.15, 0.06 |  |  |  |
Kanniess et al | Authors report no significant difference (CIC vs. BUD) | Â | Â | Â | Â |
Patient Symptoms | |||||
Lee, Fardon et al | Authors report no significant difference (CIC vs. FP) | ||||
Lee, Haggart et al | Â | Â | Â | Â | Â |
 |  | 95% CI for CIC vs. FP |  |  |  |
 | PEF (am) (l/min) | -12, 14 |  |  |  |
 | PEF (pm) (l/min) | -11. 17 |  |  |  |
 | Asthma symptom score (am) | -0.3, 0.1 |  |  |  |
 | Asthma symptom score (pm) | -0.3, 0.1 |  |  |  |
 | Rescue (am) (puffs/day) | -0.4, 0.2 |  |  |  |
 | Rescue (am) (puffs/day) | -0.3, 0.1 |  |  |  |
Quality of Life | |||||
Lee, Fardon et al | Authors report no significant difference (CIC vs. FP) | ||||
Lee, Haggart et al | Â | Â | Â | Â | Â |
 |  | 95% CI for CIC vs. FP |  |  |  |
 | Activities | -0.26, 0.92 |  |  |  |
 | Symptoms | -0.45, 0.56 |  |  |  |
 | Emotions | -0.76, 0.37 |  |  |  |
 | Environment | -1.08, 0.02 |  |  |  |
 | Overall | -0.43, 0.37 |  |  |  |
Airway Responsiveness to Provoking Agent | |||||
Lee, Fardon et al | Â | Â | Â | Â | Â |
 |  | CIC vs. FP |  | ||
 |  | GMFD | 95% CI | P |  |
 | PC20 FEV1 (metacholine) | 0.1 | -0.7-0.5 | >0.05 |  |
Lee, Haggart et al | Â | Â | Â | Â | Â |
 |  | 95% CI for CIC vs. FP |  |  |  |
 | PC20 FEV1 (metacholine) | -1.2, 0.4 |  |  |  |
Kanniess et al | Authors report no significant difference (CIC vs. BUD) | ||||
Inflammatory Markers | |||||
Lee, Fardon et al | Â | Â | Â | Â | Â |
 |  | CIC vs. FP |  | ||
 |  | GMFD | 95% CI | P |  |
 | Exhaled Nitric oxide | 1.4 | 0.8–2.5 | >0.05 |  |
Lee, Haggart et al | Â | Â | Â | Â | Â |
 |  | 95% CI for CIC vs. FP |  |  | |
 | Exhaled Nitric oxide | -2.1, 7.3 |  |  | |
Kanniess et al | Authors report no significant difference (CIC vs. BUD) | ||||
HPA Suppression | |||||
Lee, Fardon et al | Â | Â | Â | Â | Â |
 |  | CIC vs. FP |  | ||
 |  | GMFD | 95% CI | P |  |
 | Cortisol pre-hCRF | 1.1 | 0.9–1.2 | >0.05 |  |
 | Cortisol 30 mins post-hCRF | 1.0 | 0.9–1.2 | >0.05 |  |
 | OUC | 1.5 | 1.1–2.0 | <0.05 |  |
Oropharyngeal Deposition | |||||
Nave et al | Test | Reference | Point Estimates of Molar Adjusted AUC0–60 min Ratios | 95% CI | P value |
 | des-CIC | BUD | 0.04 | 0.02 – 0.05 | < 0.0001 |
 | des-CIC | CI C | 0.08 | 0.06 – 0.11 | < 0.0001 |
 | des-CIC + CIC | BUD | 0.47 | 0.38 – 0.59 | < 0.0001 |
Richter et al | Â | Â | Â | Â | Â |
 | Test | Reference | Point Estimates of Molar Adjusted AUC0–60 min Ratios | 95% CI | P value |
 | des-CIC | FP | 0.08 | 0.05 – 0.11 | <0.00001 |
 | des-CIC | CIC | 0.17 | 0.13 – 0.22 | <0.00001 |
 | des-CIC + CIC | FP | 0.53 | 0.40 – 0.69 | <0.001 |