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Table 4 Summary of Results from RCTs Comparing Ciclesonide to Budesonide or Fluticasone

From: Inhaled ciclesonide versus inhaled budesonide or inhaled beclomethasone or inhaled fluticasone for chronic asthma in adults: a systematic review

Trial Results CIC vs. comparator
Lung Function
Lee, Fardon et al Authors report no significant difference (CIC vs. FP)
Lee, Haggart et al   95% CI for CIC vs. FP    
  FEV1 (l) -0.15, 0.06    
Kanniess et al Authors report no significant difference (CIC vs. BUD)     
Patient Symptoms
Lee, Fardon et al Authors report no significant difference (CIC vs. FP)
Lee, Haggart et al      
   95% CI for CIC vs. FP    
  PEF (am) (l/min) -12, 14    
  PEF (pm) (l/min) -11. 17    
  Asthma symptom score (am) -0.3, 0.1    
  Asthma symptom score (pm) -0.3, 0.1    
  Rescue (am) (puffs/day) -0.4, 0.2    
  Rescue (am) (puffs/day) -0.3, 0.1    
Quality of Life
Lee, Fardon et al Authors report no significant difference (CIC vs. FP)
Lee, Haggart et al      
   95% CI for CIC vs. FP    
  Activities -0.26, 0.92    
  Symptoms -0.45, 0.56    
  Emotions -0.76, 0.37    
  Environment -1.08, 0.02    
  Overall -0.43, 0.37    
Airway Responsiveness to Provoking Agent
Lee, Fardon et al      
   CIC vs. FP  
   GMFD 95% CI P  
  PC20 FEV1 (metacholine) 0.1 -0.7-0.5 >0.05  
Lee, Haggart et al      
   95% CI for CIC vs. FP    
  PC20 FEV1 (metacholine) -1.2, 0.4    
Kanniess et al Authors report no significant difference (CIC vs. BUD)
Inflammatory Markers
Lee, Fardon et al      
   CIC vs. FP  
   GMFD 95% CI P  
  Exhaled Nitric oxide 1.4 0.8–2.5 >0.05  
Lee, Haggart et al      
   95% CI for CIC vs. FP   
  Exhaled Nitric oxide -2.1, 7.3   
Kanniess et al Authors report no significant difference (CIC vs. BUD)
HPA Suppression
Lee, Fardon et al      
   CIC vs. FP  
   GMFD 95% CI P  
  Cortisol pre-hCRF 1.1 0.9–1.2 >0.05  
  Cortisol 30 mins post-hCRF 1.0 0.9–1.2 >0.05  
  OUC 1.5 1.1–2.0 <0.05  
Oropharyngeal Deposition
Nave et al Test Reference Point Estimates of Molar Adjusted AUC0–60 min Ratios 95% CI P value
  des-CIC BUD 0.04 0.02 – 0.05 < 0.0001
  des-CIC CI C 0.08 0.06 – 0.11 < 0.0001
  des-CIC + CIC BUD 0.47 0.38 – 0.59 < 0.0001
Richter et al      
  Test Reference Point Estimates of Molar Adjusted AUC0–60 min Ratios 95% CI P value
  des-CIC FP 0.08 0.05 – 0.11 <0.00001
  des-CIC CIC 0.17 0.13 – 0.22 <0.00001
  des-CIC + CIC FP 0.53 0.40 – 0.69 <0.001