Table 3 RCT Methodological Characteristics
| Author | Year | Population | Comp. | Duration | Conceal-ment | Blinding | Random-isation | Attrition | Balance at baseline | Equal handling | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Kanniess et al | 2001 | No. completing | 15 | BUD |
2 weeks crossover 3–8 weeks washout | No info about allocation | Participant | Yes | Yes but no evidence of method | 1 (5.25%) | no | yes |
| Mean age | 33 | Admin. | no | |||||||||
| Stable | yes | Observer | yes | |||||||||
| Non smokers only | yes | Analyst | ? | |||||||||
| Mean FEV1 % pred: | 94 | |||||||||||
| Nave et al | 2005 | No. completing | 18 | BUD | Combined treatment Oropharyngeal washings taken at 0 mins on day 1, 15 mins on day2, 30 mins on day 3, 45 mins on day 4 and 60 mins on day 5. | No info about allocation | Participant | no | Yes but no evidence of method | 0 | yes | yes |
| Mean age | 33 | Admin. | no | |||||||||
| Stable | yes | Observer | no | |||||||||
| Non smokers only | no | Analyst | ? | |||||||||
| Mean FEV1 % pred: | ? | |||||||||||
| Lee, Fardon et al | 2005 | No. completing | 14 | FP | 4 weeks crossover 2 weeks washout | No info about allocation | Participant | yes | Yes but no evidence of method | 6 (30%) | yes | yes |
| Mean age | 47 | Admin. | ? | |||||||||
| Stable | yes | Observer | ? | |||||||||
| Non smokers only | yes | Analyst | ? | |||||||||
| Mean FEV1 % pred: | 77 | |||||||||||
| Lee, Haggart et al | 2004 | No. completing | 19 | FP | 4 weeks crossover 2 weeks washout | No info about allocation | Participant | yes | Yes but no evidence of method | 4 (17.5%) | yes | yes |
| Mean age | 45 | Admin. | ? | |||||||||
| Stable | yes | Observer | ? | |||||||||
| Non smokers only | yes | Analyst | ? | |||||||||
| Mean FEV1 % pred: | 90 | |||||||||||
| Richter et al | 2005 | No. completing | 18 | FP | Combined treatment Treatement 5–14 days (5 treatments in total at 0, 15, 30, 45 and 60 minutes). Minimum 1 day washout | No info about allocation | Participant | no | Yes but no evidence of method | 0 | yes | yes |
| Mean age | 37 | Admin. | no | |||||||||
| Stable | yes | Observer | no | |||||||||
| Non smokers only | no | Analyst | ? | |||||||||
| Mean FEV1 % pred: | 91 | |||||||||||
