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Table 3 RCT Methodological Characteristics

From: Inhaled ciclesonide versus inhaled budesonide or inhaled beclomethasone or inhaled fluticasone for chronic asthma in adults: a systematic review

Author Year Population Comp. Duration Conceal-ment Blinding Random-isation Attrition Balance at baseline Equal handling
Kanniess et al 2001 No. completing 15 BUD 2 weeks crossover 3–8 weeks washout No info about allocation Participant Yes Yes but no evidence of method 1 (5.25%) no yes
   Mean age 33     Admin. no     
   Stable yes     Observer yes     
   Non smokers only yes     Analyst ?     
   Mean FEV1 % pred: 94          
Nave et al 2005 No. completing 18 BUD Combined treatment Oropharyngeal washings taken at 0 mins on day 1, 15 mins on day2, 30 mins on day 3, 45 mins on day 4 and 60 mins on day 5. No info about allocation Participant no Yes but no evidence of method 0 yes yes
   Mean age 33     Admin. no     
   Stable yes     Observer no     
   Non smokers only no     Analyst ?     
   Mean FEV1 % pred: ?          
Lee, Fardon et al 2005 No. completing 14 FP 4 weeks crossover 2 weeks washout No info about allocation Participant yes Yes but no evidence of method 6 (30%) yes yes
   Mean age 47     Admin. ?     
   Stable yes     Observer ?     
   Non smokers only yes     Analyst ?     
   Mean FEV1 % pred: 77          
Lee, Haggart et al 2004 No. completing 19 FP 4 weeks crossover 2 weeks washout No info about allocation Participant yes Yes but no evidence of method 4 (17.5%) yes yes
   Mean age 45     Admin. ?     
   Stable yes     Observer ?     
   Non smokers only yes     Analyst ?     
   Mean FEV1 % pred: 90          
Richter et al 2005 No. completing 18 FP Combined treatment Treatement 5–14 days (5 treatments in total at 0, 15, 30, 45 and 60 minutes). Minimum 1 day washout No info about allocation Participant no Yes but no evidence of method 0 yes yes
   Mean age 37     Admin. no     
   Stable yes     Observer no     
   Non smokers only no     Analyst ?     
   Mean FEV1 % pred: 91