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Table 3 Immunoglobulin Secretion from B-cells after in-vitro mitogenic stimuli in Pediatric Hypogammaglobulinemia

From: Symptomatic hypogammaglobulinemia in infancy and childhood – clinical outcome and in vitro immune responses

  SAC PWM LPS
  IgM IgG IgA IgM IgG IgA IgM IgG IgA
Hypogamma 1.6 1.2 * 1.1 ** 1.1 * 1.4 * 1.3 * 1.3 * 2.0 * 1.1 *
  (0.6–2.6) (0.9–1.5) (1.0–1.2) (0.9–1.3) (0.9–1.9) (1.0–1.6) (1.1–1.5) (1.1–2.9) (1.0–1.2)
Corrected 2.8 1.0 * 1.3 * 1.0 * 1.1 ** 1.3 * 2.2 * 1.5 * 1.2 *
  (1.7–3.9) (0.9–1.1) (1.0–1.6) (0.9–1.1) (1.0–1.2) (1.1–1.5) (1.4–3.0) (1.2–1.8) (1.0–1.4)
Normal 3.0 2.5 2.3 2.6 3.0 2.2 4.4 5.0 3.4
  (2.5–3.5) (1.9–3.1) (1.8–2.8) (2.2–3.0) (2.4–3.6) (1.7–2.7) (3.9–4.9) (3.5–6.5) (3.0–3.8)
  1. SAC – Staph. Aureus Cowan. PWM – Pokeweed Mitogen
  2. LPS – Lipopolysacharide
  3. Values are given as Secretion Index Mean and (95% confidence interval)
  4. ** p < 0.005 compared to normal controls
  5. * p < 0.05 compared to normal controls
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