Table 2 Mean changes in metabolic parameters between baseline and endpoint in women treated with placebo or paroxetine
Placebo (n = 6) | Paroxetine (n = 7) | 95% confidence interval of difference between groups | p* | |||
|---|---|---|---|---|---|---|
Mean | SD | Mean | SD | |||
Body weight (kg) | -0.83 | 0.98 | -0.71 | 2.29 | -2.30 to 2.06 | 0.60 |
Body mass index (kg/m2) | -0.31 | 0.38 | -0.26 | 0.88 | -0.88 to 0.79 | 0.51 |
Blood glucose (mmol/l) | -0.78 | 0.58 | -1.47 | 2.52 | -1.65 to 3.03 | 0.72 |
HbA1c % | -0.07 | 0.33 | -0.44 | 0.37 | -0.05 to 0.80 | 0.08 |
S-cholesterol (mmol/l) | -0.37 | 0.72 | -0.16 | 0.62 | -1.05 to 0.63 | 0.47 |
HDL-cholesterol (mmol/l) | -0.07 | 0.10 | 0.01 | 0.13 | -0.22 to 0.07 | 0.28 |
LDL-cholesterol (mmol/l) | -0.38 | 0.65 | -0.31 | 0.51 | -0.80 to 0.68 | 0.57 |
S-triglycerides (mmol/l) | 0.16 | 0.28 | 0.31 | 0.77 | -0.87 to 0.58 | 0.72 |
Free fatty acids (mmol/l) | -0.13 | 0.48 | -0.29 | 0.41 | -0.40 to 0.71 | 0.56 |
Sex hormone binding globulin (nmol/l) | -9.33 | 15.67 | 20.29 | 20.57 | -51.81 to -7.43 | 0.01 |
S-leptin (ng/ml) | -3.75 | 6.73 | -3.54 | 5.99 | -8.12 to 7.70 | 0.89 |
S-cortisol (nmol/l) | 104.83 | 151.05 | -42.29 | 133.73 | -30.17 to 324.41 | 0.06 |
Energy expenditure (kcal/d) | -33.33 | 157.69 | 28.57 | 177.05 | -266.35 to 142.54 | 0.57 |