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Table 4 Effect of major trials on reductions in total cholesterol concentration

From: Statins in hypercholesterolaemia: A dose-specific meta-analysis of lipid changes in randomised, double blind trials

 

Number of patients

 

Weighted mean

Statin and dose (mg)

Randomised

Analysed

Initial [TC]

Absolute change

Percent change

Lovastatin

     

20 mg all studies

1967

1967

6.7

-1.2

-17

20 mg minus EXCEL

325

325

7.0

-1.2

-18

20 mg EXCEL

1642

1642

6.7

-1.1

-17

40 mg all studies

3743

3743

6.8

-1.5

-23

40 mg minus EXCEL

452

452

7.5

-1.5

-20

40 mg EXCEL

3291

3291

6.7

-1.5

-23

Pravastatin

     

40 mg all studies

8761

6635

6.5

-1.3

-21

40 mg minus WOSCOPS

5414

3333

6.1

-1.3

-21

40 mg WOSCOPS

3302

3302

7.0

-1.4

-20

Simvastatin

     

20–40 mg all studies

2406

2406

6.5

-1.6

-25

20–40 mg minus 4S study

185

185

6.4

-1.2

-19

20–40 mg 4S study

2221

2221

6.5

-1.6

-25

40 mg all studies

10952

10952

5.7

-1.5

-26

40 mg minus MRC/BHF

683

683

7.7

-2.3

-30

40 mg MRC/BHF

10269

10269

5.6

-1.5

-26

  1. * Initial [TC]: mean concentration of total cholesterol, in mmol/L, at baseline