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Table 1 Summary of results

From: S-carboxymethylcysteine in the treatment of glue ear: quantitative systematic review

  

Number/Total (%) improved

   

Results by:

Number

with

with

Relative benefit

NNT

 

of

S-CMC

placebo

(95% CI)

(95% CI)

 

studies

    

Children

4

54/14

30/140

1.7 (1.2 to 2.4)

6.1 (3.7 to 17)

  

(38)

(21)

  

Ears

3

23/77

5/69

3.8 (1.6 to 9.1)

4.4 (2.9 to 9.3)

  

(30)

(7)

  

Combined

7

77/220

35/209

2.0 (1.4 to 2.8)

5.5 (3.8 to 9.8)

  

(35)

(17)

  

Sensitivity analysis (ears or children)

Quality score ≥3

4

44/153

21/153

2.1 (1.3 to 3.3)

6.7 (4.2 to 17)

Quality score ≤2

3

33/67

14/56

1.9 (1.2 to 3.1)

4.1 (2.5 to 13)

Validity score >8

3

38/123

23/120

1.5 (0.96 to 2.3)

8.5 (4.4 to 105)

Validity score ≤7

4

39/97

12/89

3.0 (1.7 to 5.1)

3.7 (2.6 to 6.8)

Intention-to-treat

4

53/164

22/171

2.5 (1.6 to 3.9)

5.1 (3.6 to 9.3)

Per protocol

3

24/56

13/38

1.3 (0.75 to 2.2)

11.6 (3.5 to -8.9)

More than 50 in

2

33/124

14/131

2.5 (1.4 to 4.5)

6.3 (4.0 to 15)

total

     

Fewer than 50

5

44/96

21/78

1.7 (1.2 to 2.6)

5.3 (3.0 to 20)

total

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