- Research article
- Open Access
- Open Peer Review
Quality of family history collection with use of a patient facing family history assessment tool
BMC Family Practice volume 15, Article number: 31 (2014)
Studies have shown that the quality of family health history (FHH) collection in primary care is inadequate to assess disease risk. To use FHH for risk assessment, collected data must have adequate detail. To address this issue, we developed a patient facing FHH assessment tool, MeTree. In this paper we report the content and quality of the FHH collected using MeTree.
Design: A hybrid implementation-effectiveness study. Patients were recruited from 2009 to 2012. Setting: Two community primary care clinics in Greensboro, NC. Participants: All non-adopted adult English speaking patients with upcoming appointments were invited to participate. Intervention: Education about and collection of FHH with entry into MeTree. Measures: We report the proportion of pedigrees that were high-quality. High-quality pedigrees are defined as having all the following criteria: (1) three generations of relatives, (2) relatives’ lineage, (3) relatives’ gender, (4) an up-to-date FHH, (5) pertinent negatives noted, (6) age of disease onset in affected relatives, and for deceased relatives, (7) the age and (8) cause of death (Prim Care 31:479–495, 2004.).
Enrollment: 1,184. Participant demographics: age range 18-92 (mean 58.8, SD 11.79), 56% male, and 75% white. The median pedigree size was 21 (range 8-71) and the FHH entered into MeTree resulted in a database of 27,406 individuals. FHHs collected by MeTree were found to be high quality in 99.8% (N = 1,182/1,184) as compared to <4% at baseline. An average of 1.9 relatives per pedigree (range 0-50, SD 4.14) had no data reported. For pedigrees where at least one relative has no data (N = 497/1,184), 4.97 relatives per pedigree (range 1-50, SD 5.44) had no data. Talking with family members before using MeTree significantly decreased the proportion of relatives with no data reported (4.98% if you talked to your relative vs. 10.85% if you did not, p-value < 0.001.).
Using MeTree improves the quantity and quality of the FHH data that is collected and talking with relatives prior to the collection of FHH significantly improves the quantity and quality of the data provided. This allows more patients to be accurately risk stratified and offered appropriate preventive care guided by their risk level.
The systematic collection of family health history (FHH) can identify individuals at increased risk for common diseases [1–5]; many evidence-based guidelines rely upon risk assessment using FHH to guide the appropriate use of alternative (non-routine) screening procedures (such as breast MRI) and/or genetic counseling [6–9]. However, to use FHH for risk assessment, collected FHHs must have adequate detail. Unfortunately, studies have shown that the quality of FHH as currently collected in primary care is inadequate to assess disease risk [10–16]. Existing challenges include lack of patient preparation to provide FHH [17, 18], the amount of time needed to collect FHH [19, 20], lack of standardization, and limited training in synthesizing FHH data into a clinically actionable care plan [4, 18, 21, 22]. The use of a FHH collection tool with risk assessment and clinical decision support (CDS) may address these challenges and increase the comprehensiveness of FHH collection and risk assessment in primary care .
To address these challenges the Genomedical Connection, a collaboration of Duke University, the University of North Carolina at Greensboro, and Cone Health, developed the Genomic Medicine Model with funding from the Department of Defense. The model [23, 24], provides education to patients, providers, and community members; activates patients; and leverages a web-based software platform, MeTree , developed to promote accurate, high quality patient-entered FHHs for risk assessment in primary care. MeTree collects information about 48 diseases and provides risk assessment and CDS for five: breast, ovarian, and colon cancer, thrombophilia, and hereditary cancer syndromes. CDS documents include a 3 generation pedigree, a tabular FHH for PCPs, and two separate reports one for patients explaining their risk level and important points to discuss with their providers, and one for PCPs that indicates each individual’s level of risk, what put them at that risk, and what preventive actions can be taken to manage their risk . This combination of patient education and integration with primary care is different from other FHH studies [26, 27]. To assess the impact of the Genomic Medicine Model, MeTree was integrated into two primary care practices as part of a type II hybrid implementation-effectiveness controlled clinical trial [28, 29]. This paper describes the content and quality of the FHHs collected using MeTree.
The protocol for the clinical trial has been previously published . In brief, all adult patients scheduled for an upcoming well visit in two primary care practices were invited to participate. Only those who were adopted or did not speak English were excluded. Patients who agreed to participate were consented and provided with two brochures, one about how and why to collect FHH developed in conjunction with the Genetic Alliance, which included language about types of cancers and how to distinguish primary from secondary tumor sites, and another about disease risk and prevention. They were also given a worksheet with a list of relatives and a list and description of the conditions collected by MeTree to facilitate data collection from relatives prior to entering their information into MeTree. Further information about the development of these educational materials has been previously published . A study coordinator was available to assist with questions. After patient s entered their FHH into MeTree, they completed a survey regarding who they talked to and what they learned when collecting their FHH. The study was approved by the IRBs of Duke University, University of North Carolina at Greensboro, Cone Health System, and the funding agency, the Department of Defense.
FHH data and statistical analyses
FHH pedigree data entered into MeTree was stored in a SQL database and analyzed using R statistical software . To define the characteristics and quality of the entered FHH we used the following criteria defined by Bennett : (1) three generations of relatives, (2) relatives’ lineage (e.g. paternal or maternal side), (3) relatives’ gender, (4) an up-to-date FHH, (5) pertinent negatives in FHH noted (i.e. no FHH of cancer), (6) age of disease onset in affected relatives, and for deceased relatives, (7) the age and (8) cause of death. The nature of the study meant that all the FHHs were “up to date”; therefore, we limited analyses to the remaining 7 criteria. Hence in pedigrees with no deceased relatives we defined 5 possible criteria (excluding criteria 7 and 8 which related to deceased relatives) and in those with at least one deceased relative, we defined 7 possible criteria. For a pedigree to be considered high quality, at least one individual in the pedigree must meet all quality criteria (“high quality relative”), similar to previous study definitions . To understand the impact of MeTree using broader definitions the percent of pedigrees meeting high quality criteria as a function of the number of “high quality” relatives is also reported.
Throughout this paper we present data in two ways:
Data aggregated by proband (enrolled patient): counts, proportions and averages for each proband’s pedigree were calculated and then further analyzed to show the distribution of counts, proportions and averages across all pedigrees. Data representing analysis of a pedigree will be annotated by the term “pedigree” throughout this paper and data describing the proportion of relatives meeting specific criteria will be termed “proportion within pedigree”.
Data aggregated by all individuals (enrolled patient and relatives): In this case, each person represents a data point, and all counts, proportions and averages represent the entire group of individuals without reference to which pedigree he or she belongs. As an example, for breast cancer prevalence the number of individuals listed as having breast cancer in the database was divided by the total number of individuals in the database. Data representing analysis of individuals without reference to the pedigree will be annotated by the term “individual” and data describing the proportion of individuals in the database meeting specific criteria will be termed “prevalence across individuals” without respect to pedigree membership.
To assess the generalizability of our population, we compared disease prevalence and heritability within our families to the general population using relative-type recurrence-risk ratios (lambdas) [32–34]. Lambdas represent the probability that a relative (e.g. sibling) will have a disease given the proband has the disease divided by the probability that the underlying population (in our case the enrolled patient) has the disease. We compare lambdas for our population to previously published population-based lambdas for siblings, since on average they share 50% of their DNA.
In calculation of quality criteria and disease prevalence, individuals were only counted once. For example, if a patient’s aunt had breast cancer and thrombosis, she would meet quality criterion for age of disease onset if the age of onset for only one of the diseases was entered. In addition, when calculating disease prevalence across individuals she would only be counted once for overall disease prevalence. But, when looking at individual diseases she would be counted in both the breast cancer and thrombosis categories. Numerical outcome variables were analyzed using multivariate analysis with standard linear regression, and categorical variables with logistic linear regression. Covariates evaluated include: age, gender, ethnicity, education level, family size, percent of family with cancer, proband’s perception of their knowledge of their FHH.
5,971 patients were contacted for participation in the study. 4,277 (72%) agreed to participate. However, given that there was only one designated computer in each clinic, only one participant per clinic could be enrolled per hour, thus 1,184 patients were enrolled and entered their FHH into MeTree. Enrollees were similar to the underlying clinic population with the exception of slightly more women and slightly fewer minorities than the general clinic population. (Table 1) Median pedigree size was 21 (range 8-71) (Figure 1) with 27,406 individuals entered in the database.
Talking to relatives
53.89% (N = 638/1184) of patients contacted relatives to collect FHH. Those who contacted family talked to an average of 2.89 relatives (SD 1.58). Patients were more likely to contact family if they were women (57.35% vs. 48.98% of men, p = 0.004) or had more cancer in the family (15.15% vs. 12.15%, p < 0.001) and women (3.04 vs. 2.62 relatives for men, p < 0.001) and those with larger pedigrees (correlation = 0.13, slope = 0.02/relative, p < 0.001) talked to more relatives. For those who did not talk to their relatives, the most common reasons were: already knowing their FHH (N = 252/541, 46.58%), family not being available (N = 162/541, 29.94%), and having no time (N = 97/541, 17.92%).
Perceptions of FHH knowledge
Regarding FHH knowledge the mean score was 4.30 (SD = 1.30) on a Likert scale (with 1 = no knowledge and 7 = knowing nearly everything). Knowledge perception was positively correlated with percent of pedigree with cancer (correlation = 0.16, slope = 1.97/percent increase, p-value < 0.001.) Women also tended to feel they had a higher knowledge of their FHH (4.46 vs. 4.08 for mean, p-value < 0.001).
MeTree ensures the first 4 FHH quality criteria are met: three generations, relatives’ lineage, relatives’ gender, and pertinent negatives. No predictors of quality were identified during multivariate analyses. Table 2 shows data comparing FHHs meeting each criteria with MeTree to that found during a chart review of FHH prior to study start . In all categories except cause of death, MeTree FHHs met more criteria.
Age of disease onset
The mean proportion within pedigree for reporting age of disease onset was 8% (range 0.0-40.0%, SD 7.0). Within the subgroup of pedigrees with at least one relative with age of disease onset reported (N = 854/1184, 72.13%) it was 10% (range 1.0-40.0%, SD 7.0).
Cause of death
The mean proportion within pedigree for reporting the cause of death for deceased relatives was 12% (range 0.0-100%, SD 15.0). Within the subgroup of pedigrees with at least one relative with cause of death reported (N = 695/1179, 58.95%) it was 21% (range 3.0-100%, SD 15.0).
Age of death
The mean proportion within pedigree for reporting the age of death on deceased relatives was 88% (range 0.0-100%, SD 23.0). Within the subgroup of pedigrees with at least one relative with age of death reported (N = 1156/1179, 98.05%) it was 89% (range 9.0-100%, SD 19.0).
Age and cause of death
The mean proportion within pedigree for reporting both the age and cause of death on deceased relatives was 6% (range 0.0-100%, SD 11.0). Within the subgroup of pedigrees with at least one relative with age and cause of death reported (N = 479/1179, 40.62%) it was 16% (range 3.0-100%, SD 11.0).
High quality pedigrees
FHHs collected by MeTree were high quality in 99.83% (N = 1182/1184) when requiring only one relative to meet all the quality criteria. Figure 2 shows how the proportion of high quality FHHs changes as the proportion of relatives required to meet all of the quality criteria (high quality relatives) increases from 0 to 1. Even when 40% of the pedigree must contain high quality relatives, over 60% of the FHHS were still high quality.
Relatives with no reported data
Given how MeTree structures FHH collection, it is not possible to differentiate relatives who are healthy, and therefore do not have any diseases, from relatives for whom the patient does not know their medical history. Since we cannot distinguish, we report the frequency of having no data reported for any given relative (“no data”) and for relative categorized by degree of relatedness to the patient.
For all pedigrees the proportion within pedigree of no data relatives was 8% (range 0.0-8.6%, SD 1.4) (an average of 1.9 relatives/pedigree (range 0-50, SD = 4.14)). For the subgroup of pedigrees with at least one no data relative (N = 452/1184) the proportion increased to 20% (range 1.0-50.0%, SD = 5.4) or 4.97 relatives/pedigree (range 1-50, SD = 5.44). Having a lower proportion within pedigree of no data relatives was associated with FHH knowledge (correlation = -0.19, slope = -0.02/point increase in FHH knowledge, p-value < 0.001) and talking with family members (4.98% if talked to a relative vs. 10.85% if did not, p-value < 0.001). Talking with family members also increased the number of pedigrees for which 100% of relatives had at least some information entered (70.38% if talked to a relative vs. 51.83% if did not, p-value < 0.001). Multivariate analyses indicated that African-Americans (OR = 3.24, CI 1.95-5.41, p-value < 0.001) and older patients (OR = 1.04, CI 1.01-1.06, p-value < 0.001) were more likely to have relatives with no data; but having a larger pedigree had no effect.
First degree relatives (FDR)
On average the proportion within pedigree of FDRs with no data (e.g. parents, siblings, children) was 1% (range 0.0-89%, SD 5.0). However, only 30 pedigrees of the total 1,184 had an FDR with no data, and among this small subgroup the proportion was much higher at 26% (range 7.0-89%, SD 17.0).
Second degree relatives (SDR)
A larger percentage of SDRs (e.g. grandparents, aunts) had no data, 11% (range 0.0-100%, SD = 21.0). Among pedigrees with at least one SDR with no data (N = 447/1184) the mean proportion was 30% (range 2.0-100%, SD = 25.0). Grandparents were the most likely SDR to have no data (mean = 16%, range 0.0-1.00, SD = 28.0) and among pedigrees with at least one grandparent with no data (N = 345/1184) the proportion increased to 54% (range 25.0-100%, SD = 25.0).
The mean proportion within pedigree of deceased relatives was 46% (range 0.0-95%, SD = 18.0); only 5 pedigrees had no deceased relatives. Prevalence across individuals for deceased relatives was 44.75% (N = 12,264). Of those who were deceased, 30% were FDRs and 59% SDRs (of which 42% were grandparents).
Disease proportion and risk recurrence ratios
When looking at probands only, the disease prevalence rates were: breast cancer 6.48% (N = 45/694), colon cancer 0.42% (N = 5/1184), diabetes 9.29% (N = 110/1184), heart attack 3.04% (N = 36/1184). This is comparable to age adjusted national prevalence rates for: diabetes (9.4%) , heart disease (6.4%) (which includes heart attack as well as other forms of heart disease) , and colon cancer (0.50%) ; though the rate of breast cancer was higher than the national rate (3.7%) . When looking at prevalence across individuals the rates were as follows: ovarian cancer 0.97% (N = 133/13,659 females), breast cancer 4.71% (N = 644/13,659 females) with an additional 2 men, colon cancer 1.37% (N = 376/27,406), hereditary cancer syndromes 0.91% (N = 250/27,406), thrombosis 1.76% (N = 482/27,406), “heart attacks” 8.76% (N = 2400/27,406), diabetes 6.36% (N = 1744/27,406), asthma 2.82% (N = 744/27,406), and dementia 3.60% (N = 987/27,406). Sibling recurrence-risk ratios were as follows: breast cancer 2.61 (CI 1.29-4.65), colon cancer 27.86 (CI 0-91.22), heart attack 5.89 (CI 2.44-10.49), and diabetes 2.49 (CI 1.79-3.18), which are similar to reported population values for: breast cancer (1.8), colon cancer (2.7), ischemic heart disease (2.0), and diabetes (5.3) .
MeTree provides a significant improvement in the quality and content of FHH collection and thereby improves our ability to perform risk assessment and appropriately identify individuals meeting criteria for “non-routine” screening or diagnostic strategies based on current clinical guidelines. Other structured tools such as Health Heritage have also found improvements in collection of FHH and the ability to provide risk assessments [26, 39, 40]. We found that by educating patients about how and what to collect for FHH, patients talked with relatives and were able to give more, higher quality information. Those who talked with their relatives and those with higher perceptions of their FHH knowledge were more likely to have data reported on all family members and have a lower proportion of relatives with no data entered (no data relatives). As the amount and the quality of data on each relative improves, the ability to perform accurate risk assessment is also improved; and, as shown by the fact that over 60% of MeTree pedigrees had at least 40% of relatives meeting all the quality criteria (Figure 2), it will allow risk assessments to occur at higher rates than what currently occurs in practice.
To assess the generalizability of our findings, we compared the data to published population values. In particular, we wanted to evaluate whether those who participated were more likely to have a disease or have family members with a disease that would activate them, making them more likely to report a higher quality FHH than the general population. We found that those who participated in this study had similar disease prevalence for colon cancer  and diabetes  but a slightly higher prevalence of breast cancer  as compared to national statistics. They also had a higher disease prevalence within their families for colon cancer  and breast cancer [41, 42]. However, sibling recurrence-risk ratios, which take into consideration the relationships of affected members within families, were consistent with reported population values across all diseases . From this we conclude that because the probands were demographically similar to the underlying clinic population, to the disease prevalence in the general U.S. population, and to the sibling risk-ratios in the general U.S. population, our findings are likely to be generalizable despite being slightly enriched with probands with breast cancer. In addition, because few probands had any of the diseases (even though the percentage for breast cancer was higher), the effect of a recruitment bias, if present, is expected to be minimal.
There are some other biases that must be taken into account in the interpretation of this data. A higher percentage of patients’ FHHs collected by primary care providers (PCP)  (as seen in the baseline chart review) contained cause of death information than those collected in MeTree. It is highly probable that this is a result of reporting bias. In the baseline chart review, 71.8% (N = 163/227) of pedigrees had no deceased relatives mentioned at all; while with MeTree < 1% (N = 5/1184) had no deceased relatives. This highlights the difference in the type of information collected by providers. When providers do report a deceased relative they almost always report cause of death; however, they only rarely capture deceased relatives. The source of this bias is likely that providers tend to be disease focused. If patients do not know what a family member died of, providers are unlikely to make note of the death at all. In contrast the entire family structure is known with MeTree, as are all the relatives who are deceased, even if the cause of death is not known. Currently, no risk assessment algorithms take in to consideration a relative’s cause of death; only their age of death, age of disease onset, and presence of disease are considered. While this may change in the future and the collection of this information needs to be improved, it does not, at the moment, affect ability to assess risk.
Incomplete second degree relative (SDR) data poses another limitation, as SDR data, and grandparents in particular, are used in risk assessment calculations, particularly for colon cancer screening and hereditary cancer syndrome risk . The Family Healthware Intervention Trial (FHITr) also found that reporting of “don’t know” responses was significantly higher for second- versus first-degree relatives (FDR) for all six diseases assessed  at rates consistent with what we found (1% for FDR vs. 11% for SDR). We also found that probands who did not know the health history of one grandparent were much more likely not to know the others. This was improved significantly among those who talked with their relatives (10% vs. 23%, p-value < 0.001) and suggests that reporting can be improved by encouraging family discussions. However, this problem is likely to persist because of ongoing generational biases against discussing medical problems and the increasing separation of family units in today’s society.
In conclusion, MeTree provides PCPs with a higher quality FHH than they are able to collect on their own, by compensating for the lack of patient preparation and the time constraints of the clinic visit. The amount of data entered and the quality of the data were sufficient to perform risk assessments on the vast majority of patients, allowing providers to focus on review of FHH (instead of collection) and risk assessment and intervention plans based on that knowledge—both from their own knowledge of risk and on the guideline-based recommendations from MeTree.
Scheuner MT, Wang SJ, Raffel LJ, Larabell SK, Rotter JI: Family history: a comprehensive genetic risk assessment method for the chronic conditions of adulthood. Am J Med Genet. 1997, 71 (3): 315-324. 10.1002/(SICI)1096-8628(19970822)71:3<315::AID-AJMG12>3.0.CO;2-N.
Scheuner MT, Whitworth WC, McGruder H, Yoon PW, Khoury MJ: Familial risk assessment for early-onset coronary heart disease. Genet Med. 2006, 8 (8): 525-531. 10.1097/01.gim.0000232480.00293.00.
Hariri S, Yoon PW, Qureshi N, Valdez R, Scheuner MT, Khoury MJ: Family history of type 2 diabetes: a population-based screening tool for prevention?. Genet Med. 2006, 8 (2): 102-108. 10.1097/01.gim.0000200949.52795.df.
Valdez R, Yoon PW, Liu T, Khoury MJ: Family history and prevalence of diabetes in the US population: 6-year results from the National Health and Nutrition Examination Survey (NHANES, 1999 2004). Diabetes care. 2007, 30 (10): 2517-2522. 10.2337/dc07-0720.
Acheson L: Family history and genetic testing for cancer risk. Am Fam Physician. 2010, 81 (8): 934-938. author reply 934–938
Levin B, Lieberman DA, McFarland B, Smith RA, Brooks D, Andrews KS, Dash C, Giardiello FM, Glick S, Levin TR, Pickhardt P, Rex DK, Thorson A, Winawer SJ, Group American Cancer Society Colorectal Cancer Advisory, U.S. Multi-Society Task Force, and Committee American College of Radiology Colon Cancer: Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology. CA-Cancer J Clin. 2008, 58 (3): 130-160. 10.3322/CA.2007.0018.
Smith RA, Cokkinides V, Brawley OW: Cancer screening in the United States, 2008: a review of current American Cancer Society guidelines and cancer screening issues. CA-Cancer J Clin. 2008, 58 (3): 161-179. 10.3322/CA.2007.0017.
Greenland P, Alpert JS, Beller GA, Benjamin EJ, Budoff MJ, Fayad ZA, Foster E, Hlatky MA, Hodgson JM, Kushner FG, Lauer MS, Shaw LJ, Smith SC, Taylor AJ, Weintraub WS, Wenger NK, Jacobs AK, Guidelines American College of Cardiology Foundation/American Heart Association Task Force on Practice: 2010 ACCF/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2010, 122 (25): e584-e636.
American Diabetes A: Standards of medical care in diabetes–2011. Diabetes Care. 2011, 34 (Suppl 1): S11-S61.
Murff HJ, Byrne D, Syngal S: Cancer risk assessment: quality and impact of the family history interview. Am J Prev Med. 2004, 27 (3): 239-245.
Murff HJ, Greevy RA, Syngal S: The comprehensiveness of family cancer history assessments in primary care. Community Genet. 2007, 10 (3): 174-180. 10.1159/000101759.
Hayflick SJ, Eiff MP, Carpenter L, Steinberger J: Primary care physicians’ utilization and perceptions of genetics services. Genet Med. 1998, 1 (1): 13-21. 10.1097/00125817-199811000-00005.
Acton RT, Burst NM, Casebeer L, Ferguson SM, Greene P, Laird BL, Leviton L: Knowledge, attitudes, and behaviors of Alabama’s primary care physicians regarding cancer genetics. Acad Med. 2000, 75 (8): 850-852. 10.1097/00001888-200008000-00021.
Summerton N, Garrood PV: The family history in family practice: a questionnaire study. Fam Pract. 1997, 14 (4): 285-288. 10.1093/fampra/14.4.285.
Powell KP, Christianson CA, Hahn SE, Dave G, Evans LR, Blanton SH, Hauser ER, Agbaje AB, Orlando LA, Ginsburg GS, Hinrich VC: Collection of family health history for assessment of chronic disease risk in primary care. NCMJ. 2013, 74 (4): 279-286.
Christianson CA, Powell KP, Hahn SE, Blanton SH, Bogacik J, Henrich VC: The use of a family history risk assessment tool in a community health care setting: views of primary care providers. J Genet Couns. 2012, 21 (5): 652-661. 10.1007/s10897-011-9479-1.
Berg AO, Baird MA, Botkin JR, Driscoll DA, Fishman PA, Guarino PD, Hiatt RA, Jarvik GP, Millon-Underwood S, Morgan TM, Mulvihill JJ, Pollin TI, Schimmel SR, Stefanek ME, Vollmer WM, Williams JK: National institutes of health state-of-the-science conference statement: family history and improving health. Ann Intern Med. 2009, 151 (12): 872-877. 10.7326/0000605-200912150-00165.
Qureshi N, Wilson B, Santaguida P, Little J, Carroll J, Allanson J, Raina P: Family history and improving health. Evid Rep Tech Assess. 2009, 186: 1-135.
Acheson LS, Wiesner GL, Zyzanski SJ, Goodwin MA, Stange KC: Family history-taking in community family practice: implications for genetic screening. Genet Med. 2000, 2 (3): 180-185. 10.1097/00125817-200005000-00004.
Powell KP, Christianson C, Hahn SE, Dave G, Evans LR, Blanton SH, Hauser ER, Agbaje A, Orlando LA, Ginsburg GS, Hinrich VC: Collection of family health history for chronic diseases in primary care. NCMJ. 2013, 74 (4): 279-286.
Gramling R, Nash J, Siren K, Eaton C, Culpepper L: Family physician self-efficacy with screening for inherited cancer risk. Ann Fam Med. 2004, 2 (2): 130-132. 10.1370/afm.60.
Wilson BJ, Qureshi N, Santaguida P, Little J, Carroll JC, Allanson J, Raina P: Systematic review: family history in risk assessment for common diseases. Ann Intern Med. 2009, 151 (12): 878-885. 10.7326/0000605-200912150-00177.
Orlando LA, Hauser ER, Christianson C, Powell KP, Buchanan AH, Chesnut B, Agbaje AB, Henrich VC, Ginsburg G: Protocol for implementation of family health history collection and decision support into primary care using a computerized family health history system. BMC Health Serv Res. 2011, 11: 264-10.1186/1472-6963-11-264.
Orlando LA, Henrich VC, Hauser ER, Wilson C, Ginsburg GS: The genomic medicine model: an integrated approach to implementation of family health history in primary care. Pers Med. 2013, 10 (3): 295-306. 10.2217/pme.13.20.
Orlando LA, Buchanan AH, Hahn SE, Christianson CA, Powell KP, Skinner CS, Chesnut B, Blach C, Due B, Ginsburg GS, Henrich VC: Development and validation of a Primary Care-based family health history and decision support program (MeTree©). NCMJ. 2013, 74 (4): 287-296.
Cohn WF, Ropka ME, Pelletier SL, Barrett JR, Kinzie MB, Harrison MB, Liu Z, Miesfeldt S, Tucker AL, Worrall BB, Gibson J, Mullins IM, Elward KS, Franko J, Guterbock TM, Knaus WA: Health Heritage(c) a web-based tool for the collection and assessment of family health history: initial user experience and analytic validity. Public Health Genomi. 2010, 13 (7–8): 477-491.
Yoon PW, Scheuner MT, Jorgensen C, Khoury MJ: Developing Family Healthware, a family history screening tool to prevent common chronic diseases. Preventing Chronic Disease. 2009, 6 (1): A33-
Curran GM, Bauer M, Mittman B, Pyne JM, Stetler C: Effectiveness-implementation hybrid designs: combining elements of clinical effectiveness and implementation research to enhance public health impact. Med Care. 2012, 50 (3): 217-226. 10.1097/MLR.0b013e3182408812.
Brown G: Conceptual models for implementation research. 2nd Annual NIH conference on the sciene of dissemination and implementation. 2009, Bethesda, MD: NIH
R Core Team: R: A language and environment for statistical computing. 2008, Vienna, Austria
Bennett RL: The family medical history. Prim Care. 2004, 31 (3): 479-495. 10.1016/j.pop.2004.05.004. vii-viii
Risch N: Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet. 1990, 46 (2): 222-228.
Risch N: Linkage strategies for genetically complex traits. II. The power of affected relative pairs. Am J Hum Genet. 1990, 46 (2): 229-241.
Risch N: Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs. Am J Hum Genet. 1990, 46 (2): 242-253.
Valdez R, Yoon PW, Liu T, Khoury MJ: Family history and prevalence of diabetes in the U.S. population: the 6-year results from the National Health and Nutrition Examination Survey (1999–2004). Diabetes Care. 2007, 30 (10): 2517-2522. 10.2337/dc07-0720.
Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, Fullerton HJ, Gillespie C, Hailpern SM, Heit JA, Howard VJ, Kissela BM, Kittner SJ, Lackland DT, Lichtman JH, Lisabeth LD, Makuc DM, Marcus GM, Marelli A, Matchar DB, Moy CS, Mozaffarian D, Mussolino ME, Nichol G, Paynter NP, Soliman EZ, et al: Heart disease and stroke statistics–2012 update: a report from the American Heart Association. Circulation. 2012, 125 (1): e2-e220.
Cancer Fast Stats. [http://seer.cancer.gov/faststats/selections.php?#Output]
Hemminki K, Li X, Sundquist K, Sundquist J: Familial risks for common diseases: etiologic clues and guidance to gene identification. Mutat Res. 2008, 658 (3): 247-258. 10.1016/j.mrrev.2008.01.002.
Qureshi N, Carroll JC, Wilson B, Santaguida P, Allanson J, Brouwers M, Raina P: The current state of cancer family history collection tools in primary care: a systematic review. Genet Med. 2009, 11 (7): 495-506. 10.1097/GIM.0b013e3181a7e8e0.
O’Neill SM, Rubinstein WS, Wang C, Yoon PW, Acheson LS, Rothrock N, Starzyk EJ, Beaumont JL, Galliher JM, Ruffin MT, group Family Healthware Impact Trial: Familial risk for common diseases in primary care: the Family Healthware Impact Trial. Am J Prev Med. 2009, 36 (6): 506-514. 10.1016/j.amepre.2009.03.002.
Ramsey SD, Yoon P, Moonesinghe R, Khoury MJ: Population-based study of the prevalence of family history of cancer: implications for cancer screening and prevention. Genet Med. 2006, 8 (9): 571-575. 10.1097/01.gim.0000237867.34011.12.
Collaborative Group on Hormonal Factors in Breast C: Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease. Lancet. 2001, 358 (9291): 1389-1399.
Burt RW, Barthel JS, Dunn KB, David DS, Drelichman E, Ford JM, Giardiello FM, Gruber SB, Halverson AL, Hamilton SR, Ismail MK, Jasperson K, Lazenby AJ, Lynch PM, Martin EW, Mayer RJ, Ness RM, Provenzale D, Rao MS, Shike M, Steinbach G, Terdiman JP, Weinberg D, Nccn: NCCN clinical practice guidelines in oncology. Colorectal cancer screening. J Natl Compr Canc Netw. 2010, 8 (1): 8-61.
The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2296/15/31/prepub
This study is funded by the DoD. All authors are funded by the study as was time for manuscript preparation. The funding body provided IRB approval and ethical oversight of the study but did not have a role in the study design, data collection, analysis, interpretation, or in the writing of this manuscript. This material is also the result of work supported with resources and the use of facilities at the Durham, NC VA medical center by RW.
All authors declare that they have no competing interest to report.
RW participated in interpretation of data, drafted and critically revised the manuscript, and gave final approval of the current version. TH analyzed and assisted in interpretation of the data, assisted in drafting the manuscript, and gave final approval of the current version. AB contributed to concept and design of the study, critically revised the manuscript, and gave final approval of the current version. KP assisted in data acquisition and interpretation, critically revised the manuscript, and gave final approval of the current version. EH contributed to analysis and interpretation of the data, critically revised the manuscript, and gave final approval of the current version. GG contributed to conception and design of the study, critically revised the manuscript, and gave final approval of the current version. VH contributed to conception and design of the study, critically revised the manuscript, and gave final approval of the current version. LO contributed to study design, interpretation of data, critically revised the manuscript, and gave final approval of the current version. RW and LO had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the analysis. All authors have no conflicts of interest to report.
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Wu, R.R., Himmel, T.L., Buchanan, A.H. et al. Quality of family history collection with use of a patient facing family history assessment tool. BMC Fam Pract 15, 31 (2014) doi:10.1186/1471-2296-15-31
- Family history
- Data quality