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Table 1 Applied schemes for tapering long-term antidepressant usage in primary care

From: Prescribing ANtiDepressants Appropriately (PANDA): a cluster randomized controlled trial in primary care

Antidepressant AD tapering scheme (steps per 2 weeks, dose in mg/day)
  Start dose Step 1 Step 2 Step 3 Step 4
TCA      
· Amitriptyline > 150 150 100 50 25
· Imipramine > 150 150 100 50 25
· Nortriptyline > 150 150 100 50 25
· Clomipramine > 150 150 100 50 25
SSRI      
· Fluoxetine > 60 40 30 20 10
· Paroxetine > 40 40 30 20 10
· Sertraline > 150 150 100 50 25
· Citalopram > 40 40 30 20 10
· Escitalopram > 20 20 15 10 5
· Fluvoxamine > 150 150 100 50 25
Other antidepressants      
· Mirtazapine > 45 45 30 15 -
· Duloxetine > 120 120 90 60 30
· Venlafaxine > 150 150 112.5 75 37.5
· Trazodon > 150 150 100 50 -