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Agreement of general practitioners with the guideline-based stepped-care strategy for patients with osteoarthritis of the hip or knee: a cross-sectional study
© Smink et al.; licensee BioMed Central Ltd. 2013
Received: 1 November 2012
Accepted: 6 March 2013
Published: 11 March 2013
To improve the management of hip or knee osteoarthritis (OA), a multidisciplinary guideline-based stepped-care strategy (SCS) with recommendations regarding the appropriate non-surgical treatment modalities and optimal sequence for care has been developed. Implementation of this SCS in the general practice may be hampered by the negative attitude of general practitioners (GPs) towards the strategy. In order to develop a tailored implementation plan, we assessed the GPs’ views regarding specific recommendations in the SCS and their working procedures with regard to OA.
A survey was conducted among a random sample of Dutch GPs. Questions included the GP’s demographical characteristics and the practice setting as well as how the management of OA was organized and whether the GPs supported the SCS recommendations. In particular, we assessed GP’s views regarding the effectiveness of 14 recommended and non-recommended treatment modalities. Furthermore, we calculated their agreement with 7 statements based on the SCS recommendations regarding the sequence for care. With a linear regression model, we identified factors that seemed to influence the GPs’ agreement with the SCS recommendations.
Four hundred fifty-six GPs (37%) aged 30–65 years, of whom 278 males (61%), responded. Seven of the 11 recommended modalities (i.e. oral Non-Steroidal Anti-Inflammatory Drugs, physical therapy, glucocorticoid intra-articular injections, education, lifestyle advice, acetaminophen, and tramadol) were considered effective by the majority of the GPs (varying between 95-60%). The mean agreement score, based on a 5-point scale, with the recommendations regarding the sequence for care was 2.8 (SD = 0.5). Ten percent of the variance in GPs’ agreement could be explained by the GPs’ attitudes regarding the effectiveness of the recommended and non-recommended non-surgical treatment modalities and the type of practice.
In general, GPs support the recommendations in the SCS. Therefore, we expect that their attitudes will not impede a successful implementation in general practice. Our results provide several starting points on which to focus implementation activities for specific SCS recommendations; those related to the prescription of pain medication and the use of X-rays. We could not identify factors that contribute substantially to GPs’ attitudes regarding the SCS recommendations regarding the sequence for care.
Osteoarthritis (OA) of the hip or knee is a common joint disorder causing pain and functioning impairment. The core treatment for OA, a combination of pharmacological and non-pharmacological treatment modalities, is mainly performed in primary care. In the Netherlands, once the diagnosis had been established, it has been found that patients with OA are treated in general practice for approximately 82 months before they are referred to an orthopaedic department . Although several clinical practice guidelines (CPGs) to manage hip or knee OA exist [2–6], diagnostic procedures, referrals, and use of treatment modalities observed in primary care tend to be inadequate [7–9]. In addition, a recent review depicts a notably low pass rate for quality indicators for OA care (interquartile range 29-41%) . These findings support the conclusion that incorporation of CPGs into clinical practice is not that simple.
Summary of the SCS recommendations in each step 
Diagnostic procedures and assessment
- Medical history and physical examination
- Radiological assessment*
- Consultation specialist
- Assessment function and activity limitations
- Assessment of pain coping and psychosocial factors
- Adjust goals
- Setting mutual goals
- Adjust goals
- Exercise therapy
- Multidisciplinary care
- Lifestyle advice
- Dietary therapy
- Medication †
∙ (topical) NSAID’s
∙ Intra-articular injections
-After 3 months‡
-After 3–6 months‡
-Patient sets interval
To implement this strategy, the views about the SCS recommendations and working procedures concerning OA care of general practitioners (GPs) need to be assessed and the barriers that prevent GPs from using the SCS need to be identified [12–14]. This knowledge can then be used to develop implementation activities tailored for GPs. The importance of such activities, created in response to identified barriers, has been demonstrated in a recent review that reported that tailored activities are more likely to improve professional practice than non-tailored activities . Also, insight into the GPs’ views provides information concerning the strengths and weaknesses of current practice and heightens the perception of the need for change .
An approach based on a theoretical model can help to identify these barriers. Barriers are frequently grouped into social factors (including patients’ preferences), the clinicians’ attitudes, the implementation process, accessibility and format of the program, and external barriers of a practical nature [12, 16–18]. In this study, we assessed the attitudes towards the SCS recommendations expressed by GPs which could be a potential barrier to successful implementation of this strategy : specifically, their attitudes regarding the effectiveness of recommended non-surgical treatment modalities for hip or knee OA and their degree of agreement with recommendations regarding the sequence for care. Considering the fact that each recommendation can be influenced by different factors , we will assess the attitudes towards several specific SCS recommendations.
The aim of this study is to describe the GPs’ attitudes with respect to the two key elements of the SCS: 1) their attitudes regarding the effectiveness of the recommended non-surgical treatment modalities and 2) their agreement with specific recommendations regarding the sequence for care. In particular, those factors, that could influence their agreement with these recommendations, will be identified and will be used to develop tailored made implementation activities for this target group.
To estimate the prevalence of GPs who agree with the SCS recommendations with 95% confidence level and a maximal error margin of 5%, data of 369 GPs was needed for this cross-sectional study. Assuming a response rate of 30%, a random sample of 1230 GPs was drawn from all listed GPs in the Netherlands (about 8.900) by the Netherlands Institute for Health Services Research (NIVEL) in July 2011. The anonymous survey was sent to this sample, followed by a reminder after two weeks to maximize the response.
The survey consisted of questions regarding the GP’s characteristics and their practice setting, as well as the organization of OA management and the GP’s attitudes towards the SCS recommendations.
GP’s characteristics and their practice setting
The demographic characteristics included age, sex, length of time working (expressed in years), number of working hours (expressed in fulltime equivalents (fte)), and their field of special interest (e.g. in musculoskeletal disorders (yes/no)). Practice characteristics included type of practice (solo, duo, practice group, GP centre, and health centre), location of the practice (urban, suburban, or rural), practice size (expressed in number of registered patients), number of GPs working in practice (expressed in fte), presence of practice staff (e.g. practice nurse and assistant (yes/no)) as well as other health care providers in the practice (e.g. physical therapist, dietician, physiologist, pharmacist, social worker (yes/no)).
Organization of OA management
The organization of OA management in general practice was assessed by mapping the involvement of the GP, practice nurse, and practice assistant in the following care tasks: a) providing information, b) providing lifestyle advice, c) distributing patient information material from the Dutch College of General Practitioners (NHG), d) distributing other types of information, e) referral to a dietician, f) referral to a physical or exercise therapist, and g) evaluating results at the follow-up appointment.
In addition, we assessed the type of collaboration the GP had with other health care providers involved in OA care (physical or exercise therapists, dieticians, rheumatologists, and orthopaedic surgeons) by using three items: 1) participation in periodic meetings concerning individual OA patients (yes/no), 2) following protocols or agreements concerning specific working procedures to treat OA patients (yes/no), and 3) the frequency of contact (rarely, yearly, monthly, weekly) concerning individual OA patients.
GP’s attitudes towards the SCS recommendations
We studied GPs’ attitudes towards the two key elements of the SCS: their attitude concerning the appropriate treatment and their attitude concerning the optimal sequence. Therefore, we assessed which of the frequently-used treatment modalities were found to be effective in the treatment of hip or knee OA by the GPs. Furthermore, we assessed if GPs agreed with the sequence of care that is presented in the SCS recommendations.
GP’s attitudes regarding the effectiveness of fourteen frequently-used treatment modalities were scored on a 4-point Likert scale (i.e. not effective – effective) or not applicable (“no experience with the modality”). Eleven of these modalities are recommended in the SCS (education, lifestyle advice, acetaminophen, glucosaminesulphate, oral and topical Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), physical therapy, tramadol, transcutaneous electrical nerve stimulation (TENS), hyaluronic acid, and glucocorticoid injections). Three other frequently-used modalities (massage, manual therapy, and other passive physical therapy treatment modalities, such as cold or heat therapy, ultrasound, laser therapy, or electrotherapy) are not recommended in the SCS, i.e. non-recommended modalities.
GP’s attitudes regarding the sequence for care was assessed by a 5-point Likert scale (i.e. strongly disagree, disagree, neutral, agree, and strongly agree) for seven statements. These statements were based on the SCS recommendations and thus concerned the three areas of management: diagnosis (statement 1), treatment (statement 2–6), and evaluation (statement 7). Treatment modalities from all different steps of the SCS were covered: step 1 (statement 3), step 2 (statements 2 and 4), step 3 (statement 5), and “step 4” (statement 6).
We used descriptive statistics for the GP’s characteristics and their practice setting, the organization of OA management, and the GP’s attitudes towards the SCS recommendations.
In order to examine the collaboration of the GPs with other health care providers, we constructed two variables by combining items. First, we considered collaboration “structural” (yes/no), if the GP reported to have periodic meetings or reported to follow protocols or agreements concerning specific working procedures with any other health care provider. Second, we considered collaboration “ad hoc” (yes/no), if the GP had at least monthly contact with one or more of the other health care providers.
Furthermore, we constructed two indices to examine the GPs’ attitudes regarding the effectiveness of the fourteen frequently-used non-surgical treatment modalities. One index concerned their attitude regarding the effectiveness of the eleven modalities that are recommended in the SCS, while the other index concerned their attitude regarding the effectiveness of the three non-recommended treatment modalities. We calculated an average score for both indices based on the results on the 4-point Likert scales. If more than one-third of the items was missing (i.e. four or more items for the first index and two or more items for the second index), the scores (range of 0–3; in which 0 = “negative attitude” and 3 = “positive attitude” regarding the effectiveness of the corresponding modalities) were treated as being missing. We excluded items that were ‘not applicable’ from the average score.
Finally, we used linear regression models to assess univariable and multivariable associations between the GP’s agreement with recommendations regarding the sequence for care and the characteristics relating to the GPs, the practice, or organization of management. We constructed an overall index for GPs’ agreement with the seven statements by calculating the average score of items (range of 0–4; in which 0 = “no agreement” and 4 = “complete agreement” with the SCS recommendations). For that matter, the scores on the items in which the desired response was “disagree” were reversed. The scores were treated as being missing if more than one-third of the items was missing (i.e. three or more items). The results were expressed in betas with standard error (SE). All variables that showed univariable significance (p < 0.10) were entered simultaneously into a multivariable model. Statistical analyses were executed using STATA 10.0.
Characteristics of the responders (N = 456) and the total population Dutch GPs (N = 8884)
Total population Dutch GPs*
Age (years); mean
Sex (male); %
Working hours (fte); %
Type of practice; %
Location practice; %
GP’s characteristics and their practice setting
Characteristics responding GPs and their practice setting (N = 456)
Characteristics of the GP
Age (years); mean (SD)
Sex (male); N (%)
Length of time working (years); median (IQR)
Working hours (fte); N (%)
GPwSI in musculoskeletal disorders; N (%)
Characteristics of the practice setting
Type of practice; N (%)
- Practice group
- GP centre
- Health centre
Practice size (registered patients); median (IQR)
Number of GPs working (fte); median (IQR)
Presence of practice staff; N (%)
- Practice nurse
- Practice assistant
Presence of other disciplines in same setting; N (%)
- Physical therapist
- Other (e.g. pharmacist, social worker, dentist)
Organization of OA management
Involvement of other disciplines in OA management; N (%)
- Practice nurse
- Practice assistant
Structural collaboration; N (%)
- Periodic meetings
- Following protocols and agreements on working procedures
Frequency of contact with other disciplines in OA management; N (%)
- (Almost) never
Organization of OA management
Of the 403 GPs (88%) who have a practice nurse available, 73 GPs (18%) reported that their practice nurse is involved in the OA management: “providing lifestyle advice” was the most frequently reported performed task. Of the 440 GPs (96%) who have a practice assistant available, 79 GPs (18%) reported that their practice assistant is involved in OA management: their most frequently performed task in OA management was “handing out other kind of information”.
One hundred twenty-two GPs (27%) reported having “structural” collaboration (having periodic meetings or following protocols or agreements concerning specific working procedures) with other health care providers. Two hundred twenty-seven GPs (51%) reported having “ad hoc” (at least monthly) contact with other health care providers. Both, structural and ad hoc collaboration, were generally with a physical therapist. With regard to structural collaboration, 96 (98%) of the GPs who reported having periodic meetings reported those to be with physical therapists, and 52 (95%) of the GPs who reported following protocols or agreements concerning specific working procedures reported those to be with physical therapists. In addition, 214 GPs (95%) of the GPs who reported having ad hoc contact reported that to be with physical therapists. Thirteen (4%), 38 (10%), and 64 (16%) of the GPs reported having ad hoc contact with a dietician, rheumatologist, or orthopaedic surgeon, respectively.
GPs’ attitudes towards the SCS recommendations
GPs’ attitudes regarding the effectiveness of OA treatment modalities
Not effective N (%)
Effective N (%)
No experience N (%)
Modalities recommended in the SCS
2. Lifestyle advice
5. Oral NSAIDs
6. Topical NSAIDs
8. Physical therapy
9. Glucocorticoid intra-articular injections †
10. Hyaluronic acid intra-articular injections †
Modalities not recommended in the SCS
13. Manual therapy
14. Other passive physical therapy modalities§
GPs’ agreement with SCS recommendations regarding the sequence for care
1. X-ray is necessary to diagnose OA
2. NSAIDs should only be prescribed if there is radiological OA
3. NSAIDs should be the first choice of pain medication in patients with OA
4. Physical therapy should only be prescribed if there is radiological OA
5. Intra-articular injections should only be prescribed if physical therapy and painkiller are insufficient
6. Surgical treatment modalities should only be considered if physical therapy and painkiller are insufficient
7. OA patients should be stimulated by their GP to evaluate and monitor their treatment
Determinants for a GP’s agreement with the SCS
Uni- and multivariable associations between potential barriers of GPs agreement with the SCS recommendations about the sequence for care
Length of time working, years; median (range)
GPwSI in musculoskeletal disorders; N (% yes)
Effectiveness recommended modalities (range 0–3); mean (SD)
Effectiveness non-recommended modalities (range 0–3); mean (SD)
Number of GPs working; median (range)
Number of registered patients (per 1000); median (range)
Solo practice; N (% yes)
Availability practice nurse; N (% yes)
Number of other disciplines available; median (range)
Organization of OA management
Structural collaboration; N (% yes)
Ad hoc collaboration; N (% yes)
In general, the GPs’ attitudes were in concordance with SCS recommendations regarding the non-surgical treatment modalities and the sequence for care; seven of the eleven recommended treatment modalities were considered effective for patients with hip or knee OA by the great majority of the GPs and five of the seven SCS recommendations regarding the sequence for care were consistent with the attitudes of most GPs. However, we found a notably high number of GPs who reported that tramadol, topical NSAIDs, and glucosamine were not effective and who reported that non-recommended modalities were effective in patients with hip or knee OA. Also, many GPs considered an X-ray necessary to diagnose OA and considered NSAIDs the drug of first choice (instead of acetaminophen). GPs’ agreement with SCS recommendations regarding the sequence for care was only weakly associated with a positive attitude towards the effectiveness of recommended modalities, a negative attitude towards the effectiveness of non-recommended modalities, and working in a duo or group practice.
As mentioned above, many GPs reported thought that several types of pain medication that are recommended in the SCS are not effective in patients with hip or knee OA. An explanation for the negative attitude towards tramadol could be the high prevalence of side effects [22, 23], which may result to therapy switching or discontinuation, and thus a negative evaluation of its effectiveness by GPs [24, 25]. Furthermore, the GPs’ negative attitudes towards the effectiveness of topical NSAIDs, glucosamine, and hyaluronic acid intra-articular injections might be explained by the discrepancies between the recommendations of the SCS and the Dutch NHG-standard for non-traumatic knee complaints in adults . As the SCS was developed through a consensus procedure based on several national and international guidelines, the SCS recommendations differed slightly from those of the Dutch NHG-guideline. For example, the NHG-standard recommends GPs not to use glucosamine in patients with OA and gives no recommendations regarding topical NSAIDs, while the SCS does. In general, NHG-standards have a great impact on GPs’ knowledge  and thus could have influenced GPs’ attitudes regarding the effectiveness of these modalities. Another possible explanation for the GPs’ negative attitude towards topical NSAIDs, glucosamine, and hyaluronic acid intra-articular injections is that these are not reimbursed in the Netherlands. The GPs’ positive attitude regarding the non-recommend modalities, like manual therapy and other passive modalities, could be explained by the preferences for these modalities by the patients and physical therapists. This explanation is supported by the fact that these modalities are frequently used in patients with OA .
The SCS points out that medical history and physical examination are sufficient to diagnose (symptomatic) hip or knee OA, as radiographic confirmation of OA has little impact on the management, particularly in the early stages of the disease [3, 5, 27]. Interestingly, many GPs reported that X-ray is necessary to diagnose hip or knee OA. This finding is concordant with other studies that assessed GPs’ behaviour for ordering X-rays in the management of OA or back pain [28–30]. The GPs legitimise their use of radiographs by expressing the view that it aids the discussion of management with the OA patient, is required for specialist referral, and can be used to reduce referrals . Moreover, GPs believe that X-rays provide reassurance to patients which can outweigh the risks; furthermore, denying X-rays could adversely affect the doctor-patient relationship . Although patients who have had X-ray seemed to be more satisfied, they reported more pain, lower overall health status, though no difference in disability, and consult their doctor more frequently [30, 31]. In light of this, GPs need to be informed about the limited value of X-rays in early OA.
We found three factors that are associated with the GPs’ attitude regarding the sequence for care. The first two factors, that concern the GPs’ agreement with the effectiveness of recommended and non-recommended treatment modalities, suggest that GPs who are aware of the effectiveness of these modalities agree with the SCS recommendations regarding the sequence for care. This result might be explained by the fact that these recommendations were based on evidence outlined in CPGs. Furthermore, the association between the GPs’ attitude regarding the sequence for care and the type of practice is in concordance with other studies suggesting that the organizational setting of the practice is the most consistent predictor of the GPs’ behaviour and can influence GPs’ performance [32, 33]. Generally, the isolated physician in solo practice provides a more limited range of services and show lower levels of clinical competence . Moreover, GPs in solo practices appear to have a more aggressive treatment style than those physicians in group practices, which might be explained by financial incentives, lack of peer influences and availability of colleagues for informal consultation .
This study is not without limitations. First of all, only 10% of the variance in GPs’ agreement could be explained by factors related to the GP, the practice, or the management organization for OA patients. We did not examine the contribution of person-related or situational factors, e.g., the GPs’ experience, the patients’ preferences, local infrastructures, and rules or laws on the sequence for care; these factors have been named in literature as potentially able to influence GP’s attitudes [12, 16]. Secondly, our study does not cover all professionals because the research aim of this study was restricted to GP’s views and working procedures, while implementation of the multidisciplinary SCS should involve different disciplines. However, this study is part of an umbrella project, the BART-project, which aims to implement the SCS in practice and evaluate the implementation process in one region of the Netherlands, in preparation for the nation-wide implementation. Therefore, the views and working procedures of patients and other health care providers will be studied and described at a later date. Thirdly, the self-designed survey was tailored to our target population and not validated. Fourthly, we measured the GP’s attitudes regarding recommendations of the SCS and not the GP’s actual behaviour. Although a positive relation between attitude and behaviour can be assumed  our results do not give insight into the extent that the current clinical practice is concordant with the recommendations of the SCS. Consequently, there might be other barriers that impede a successful implementation. Finally, the response rate (37%), although relatively high for these kind of surveys among GPs, can raise some concerns regarding the validity and generalizability of our findings. Although we did not find large differences in several demographic and practice-related characteristics between the responders and the total population of Dutch GPs, we are aware that non-response bias could have affected the results. It has been stated that “serial” non-responders to GP surveys tent to be older, less likely to possess a postgraduate medical qualification, or belong to a practice that is involved with postgraduate or undergraduate training.  As we expect that additional education is associated with a more positive attitude to evidence-based practice, it could be hypothesized that our findings are an overestimation of the degree of agreement with the SCS recommendations.
Given the above-mentioned findings, the GPs’ attitude regarding recommendations in the SCS is not an insurmountable barrier for implementing the SCS in general practice. GPs are supportive of the recommendations regarding the effectiveness of treatment modalities and the sequence for care. Potential targets for implementation are improving the GPs’ knowledge regarding the effectiveness and optimal sequence for diagnostic procedures and treatment modalities, particularly in GPs who are working in a solo practice. Therefore, we recommend to include these themes in the GP-guideline and embed these in the program of the (post-graduate) training program and/or post-academic training for GPs. We did not identify any barriers that substantially contribute to GPs’ agreement with the SCS recommendations regarding the sequence for care. Further efforts should be taken to identify barriers that could prevent GPs from using the SCS.
- Paans N, van der Veen WJ, van der Meer K, Bulstra SK, van den Akker-Scheek I, Stevens M: Time spent in primary care for hip osteoarthritis patients once the diagnosis is set: a prospective observational study. BMC Fam Pract. 2011, 12: 48-10.1186/1471-2296-12-48.View ArticlePubMedPubMed CentralGoogle Scholar
- National Collaborating Centre for Chronic Conditions: Osteoarthritis: national clinical guideline for care and management in adults. 2008, London: Royal College of PhysiciansGoogle Scholar
- Zhang W, Doherty M, Arden N, Bannwarth B, Bijlsma J, Gunther KP, Hauselmann HJ, Herrero-Beaumont G, Jordan K, Kaklamanis P: EULAR evidence based recommendations for the management of hip osteoarthritis: report of a task force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis. 2005, 64: 669-681. 10.1136/ard.2004.028886.View ArticlePubMedGoogle Scholar
- Zhang W, Moskowitz RW, Nuki G, Abramson S, Altman RD, Arden N, Bierma-Zeinstra S, Brandt KD, Croft P, Doherty M: OARSI recommendations for the management of hip and knee osteoarthritis, part I: critical appraisal of existing treatment guidelines and systematic review of current research evidence. Osteoarthritis Cartilage. 2007, 15: 981-1000. 10.1016/j.joca.2007.06.014.View ArticlePubMedGoogle Scholar
- Dutch Orthopadic Association: Diagnostiek en behandeling van heup- en knieartrose. (Diagnostics and treatment of osteoarthritis of the hip and knee). 2007, Kwaliteitsinstituut: Kwaliteitsinstituut voor de Gezondheidszorg (CBO)Google Scholar
- Belo JN, Bierma-Zeinstra SM, Raaijmakers AJ, Van der Wissel F, Opstelten W: NHG Standaard Niet traumatische knieproblemen bij volwassenen (eerste herziening). (NHG-Standard: Non-traumatic knee complaints in adults (first revision)). Huisarts Wet. 2008, 51: 229-240. 10.1007/BF03086753.View ArticleGoogle Scholar
- McHugh GA, Campbell M, Luker KA: Quality of care for individuals with osteoarthritis: a longitudinal study. J Eval Clin Pract. 2012, 18: 534-541. 10.1111/j.1365-2753.2010.01616.x.View ArticlePubMedGoogle Scholar
- Ng NT, Heesch KC, Brown WJ: Strategies for managing osteoarthritis. Int J Behav Med. 2012, 19: 298-307. 10.1007/s12529-011-9168-3.View ArticlePubMedGoogle Scholar
- Snijders GF, den Broeder AA, van Riel PL, Straten VH, de Man FH, van den Hoogen FH, van den Ende CH: Evidence-based tailored conservative treatment of knee and hip osteoarthritis: between knowing and doing. Scand J Rheumatol. 2011, 40: 225-231. 10.3109/03009742.2010.530611.View ArticlePubMedGoogle Scholar
- Askari M, Wierenga PC, Eslami S, Medlock S, de Rooij SE, Abu-Hanna A: Assessing quality of care of elderly patients using the ACOVE quality indicator set: a systematic review. PLoS One. 2011, 6: e28631-10.1371/journal.pone.0028631.View ArticlePubMedPubMed CentralGoogle Scholar
- Smink AJ, van den Ende CH, Vliet Vlieland TP, Swierstra BA, Kortland JH, Bijlsma JW, Voorn TB, Schers HJ, Bierma-Zeinstra SM, Dekker J: “Beating osteoARThritis”: development of a stepped care strategy to optimize utilization and timing of non-surgical treatment modalities for patients with hip or knee osteoarthritis. Clin Rheumatol. 2011, 30: 1623-1629. 10.1007/s10067-011-1835-x.View ArticlePubMedGoogle Scholar
- Grol R: Implementing guidelines in general practice care. Qual Health Care. 1992, 1: 184-191. 10.1136/qshc.1.3.184.View ArticlePubMedPubMed CentralGoogle Scholar
- Grol R, Wensing M: Effectieve implementatie: een model. Implementatie. Edited by: Effectieve verbetering van de patiëntenzorg. 2006, Maarssen: Elsevier, 65-91. 3Google Scholar
- Watkins C, Harvey I, Langley C, Gray S, Faulkner A: General practitioners’ use of guidelines in the consultation and their attitudes to them. Br J Gen Pract. 1999, 49: 11-15.PubMedPubMed CentralGoogle Scholar
- Baker R, Camosso-Stefinovic J, Gillies C, Shaw EJ, Cheater F, Flottorp S, Robertson N: Tailored interventions to overcome identified barriers to change: effects on professional practice and health care outcomes. Cochrane Database Syst Rev. 2010, CD005470-Google Scholar
- Cabana MD, Rand CS, Powe NR, Wu AW, Wilson MH, Abboud PA, Rubin HR: Why don’t physicians follow clinical practice guidelines? A framework for improvement. JAMA. 1999, 282: 1458-1465. 10.1001/jama.282.15.1458.View ArticlePubMedGoogle Scholar
- Carlsen B, Bringedal B: Attitudes to clinical guidelines–do GPs differ from other medical doctors?. BMJ Qual Saf. 2011, 20: 158-162. 10.1136/bmjqs.2009.034249.View ArticlePubMedGoogle Scholar
- Stewart RE, Vroegop S, Kamps GB, van der Werf GT, Meyboom-de JB: Factors influencing adherence to guidelines in general practice. Int J Technol Assess Health Care. 2003, 19: 546-554.View ArticlePubMedGoogle Scholar
- Farquhar CM, Kofa EW, Slutsky JR: Clinicians’ attitudes to clinical practice guidelines: a systematic review. Med J Aust. 2002, 177: 502-506.PubMedGoogle Scholar
- Lugtenberg M, Zegers-van Schaick JM, Westert GP, Burgers JS: Why don’t physicians adhere to guideline recommendations in practice?. An analysis of barriers among Dutch general practitioners. Implement Sci. 2009, 4: 54-PubMedGoogle Scholar
- Hingstman L, Kenens RJ: Figures from the registration of practitioners. 2012, Utrecht: Poll 2011Google Scholar
- Langley C, Faulkner A, Watkins C, Gray S, Harvey I: Use of guidelines in primary care–practitioners’ perspectives. Fam Pract. 1998, 15: 105-111. 10.1093/fampra/15.2.105.View ArticlePubMedGoogle Scholar
- Rosenthal NR, Silverfield JC, Wu SC, Jordan D, Kamin M: Tramadol/acetaminophen combination tablets for the treatment of pain associated with osteoarthritis flare in an elderly patient population. J Am Geriatr Soc. 2004, 52: 374-380. 10.1111/j.1532-5415.2004.52108.x.View ArticlePubMedGoogle Scholar
- Gehling M, Hermann B, Tryba M: Meta-analysis of dropout rates in randomized controlled clinical trials: opioid analgesia for osteoarthritis pain. Schmerz. 2011, 25: 296-305. 10.1007/s00482-011-1057-9.View ArticlePubMedGoogle Scholar
- Gore M, Sadosky A, Leslie D, Tai KS, Seleznick M: Patterns of therapy switching, augmentation, and discontinuation after initiation of treatment with select medications in patients with osteoarthritis. Clin Ther. 2011, 33: 1914-1931. 10.1016/j.clinthera.2011.10.019.View ArticlePubMedGoogle Scholar
- Walsh NE, Hurley MV: Evidence based guidelines and current practice for physiotherapy management of knee osteoarthritis. Musculoskeletal Care. 2009, 7: 45-56. 10.1002/msc.144.View ArticlePubMedGoogle Scholar
- Swierstra BA, Bijlsma JWJ, de JJA B, Kuijpers T: Richtlijn ‘Diagnostiek en behandeling van heup- en knieartrose’. (Guideline ‘Diagnostics and treatment of osteoarthrosis of the hip and knee’). Ned Tijdschr Geneeskd. 2009, 153.,Google Scholar
- Glazier RH, Dalby DM, Badley EM, Hawker GA, Bell MJ, Buchbinder R, Lineker SC: Management of common musculoskeletal problems: a survey of Ontario primary care physicians. CMAJ. 1998, 158: 1037-1040.PubMedPubMed CentralGoogle Scholar
- Morgan B, Mullick S, Harper WM, Finlay DB: An audit of knee radiographs performed for general practitioners. Br J Radiol. 1997, 70: 256-260.View ArticlePubMedGoogle Scholar
- Baker R, Lecouturier J, Bond S: Explaining variation in GP referral rates for x-rays for back pain. Implement Sci. 2006, 1: 15-10.1186/1748-5908-1-15.View ArticlePubMedPubMed CentralGoogle Scholar
- Kendrick D, Fielding K, Bentley E, Miller P, Kerslake R, Pringle M: The role of radiography in primary care patients with low back pain of at least 6 weeks duration: a randomised (unblinded) controlled trial. Health Technol Assess. 2001, 5: 1-69.View ArticlePubMedGoogle Scholar
- Landon BE, Reschovsky J, Reed M, Blumenthal D: Personal, organizational, and market level influences on physicians’ practice patterns: results of a national survey of primary care physicians. Med Care. 2001, 39: 889-905. 10.1097/00005650-200108000-00014.View ArticlePubMedGoogle Scholar
- Lockyer JM: Physician performance: The roles of knowledge, skill, and environment. Teach Learn Med. 1992, 4: 86-96. 10.1080/10401339209539540.View ArticleGoogle Scholar
- Ajzen I, Fishbein M: Understanding attitudes and predicting social behaviour. 1980, Englewood Cliffs, NJ: Prentice HallGoogle Scholar
- Stocks N, Gunnell D: What are the characteristics of general practitioners who routinely do not return postal questionnaires: a cross sectional study. J Epidemiol Community Health. 2000, 54: 940-941. 10.1136/jech.54.12.940.View ArticlePubMedPubMed CentralGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2296/14/33/prepub
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