Table 2 Chronic respiratory questionnaire subscale score, pulmonary function and 6-minute walking test differences from baseline to 3 and 12 months

0.4 (−0.05-0.7)

0.2 (−0.1-0.6)

0.03 (−0.3-0.4)

0.3 (−0.1-0.6)

0.5 (0.2-0.8)*

0.56 (0.2-0.9)*

−0.6 (−1.1- - 0.1)*

0.3 (−0.5-1.2)

−1.01 (−1.5- -0.5)*

0.01 (−0.8-0.8)

−0.3 (−0.8-0.15)

0.79 (0.03-1.5)*

−0.5(−0.9- - 0.1)*

−0.4 (−0. 8–0.01)

0.3 (−0.1-0.7)

0.07 (−0.3-0.5)

−0.2 (−0.6-0.2)

−0.23 (−0.6-0.1)

0.5 (0.06-1.01)*

0.00 (−0.6-0.6)

0.7 (0. 3–1.2)*

0.5 (−0.13-1.11)

0.9 (0.5-1.3)*

0.7 (0.2-1.3)*

−1.5 (−4.7-1.7)

1.42 (−2.4-5.3)

0.5 (−2.8-3.9)

3.0 (−1.04-7.05)

−2.4 (−5.5-0.6)

−0.9 (−4.7-2.7)

0.8 (−2.5-4.2)

−0.22 (−1.3-0.9)

−0.03 (−3.5-3.5)

−0.1 (−1.3-0.9)

−2.1 (−5.3-1.1)

−1.2 (−2.2- - 0.1)*

0.8 (−1.9-3.6)

3.03 (0.6-5.5)*

−0.5 (−3.3-2.2)

−1.8 (−4.3-0.6)

−0.3 (−2.8-2.2)

−0.08 (−2.3-2.1)

27.3 (4.4-50.3)*

33.2 (8.2-58.3)*

0.9 (−22.6-24.3)

20.2 (−5.3-45.8)

19.5 (−2.07-41.1)

19.7 (−3.8-43.3)