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Table 4 Prevalence and test performance of the single item screener using the “major depressive disorder” definition of the 9-item Patient Health Questionnaire (PHQ-9) as reference standard (95% confidence interval)

From: Diagnostic utility of a one-item question to screen for depressive disorders: results from the KORA F3 study

Age group Prevalence Sensitivity Specifity ROC-area LR+ LR- PPV NPV
34-44 3.8 (2.4-5.5) 75 (53.3-90.2) 92.2 (89.8-94.2) .836 (.747-.925) 9.61 (6.73-13.7) .271 (.136-.542) 27.3 (17–39.6) 99 (97.7-99.6)
45-54 6.2 (4.5-8.2) 86.7 (73.2-94.9) 89.9 (87.2-92.1) .883 (.832-.935) 8.62 (6.7-11.1) .148 (.070-.312) 36.1 (27.1-45.9) 99 (97.9-99.6)
55-64 6 (4.4-8.0) 76.1 (61.2-87.4) 84.9 (82.1-87.5) .805 (.741-.869) 5.05 (3.98-6.41) .282 (.168-.472) 24.5 (17.7-32.4) 98.2 (96.8-99.1)
65-74 7.9 (5.9-10.2) 86.5 (74.2-94.4) 85.4 (82.4-88.1) .86 (.811-.909) 5.93 (4.76-7.39) .158 (.0791-.314) 33.6 (25.7-42.2) 98.7 (97.3-99.5)
75-85 10 (7.4-14.1) 86.5 (71.2-95.5) 83.3 (78.8-87.3) .849 (.79-.909) 5.19 (3.93-6.84) .162 (.0717-.367) 37.6 (27.4-48.8) 98.1 (95.7-99.4)
Female 8.4 (7.1-9.8) 81.6 (74.1-87.7) 83.8 81.8-85.6) .827 (.973-.861) 5.04 (4.38-5.8) .219 (.154-.313) 31.5 (26.7-36.7) 98 (97.1-98.7)
Male 4.5 (3.5 -5.6) 85.3 (74.6-92.7) 91.4 (89.8-92.8) .883 (.84-.926) 9.87 (8.13-12) .161 (.0908-.285) 31.5 (24.9-38.8) 99.3 (98.6-99.6)
Total 6.5 (5.6-7.4) 82.8 (77–87.7) 87.5 (86.3-88.7) .852 (.825-.879) 6.65 (5.93-7.46) .196 (.145-.265) 31.5 (27.6-35.7) 98.7 (98.1-99.1)
  1. ROC: receiver operating characteristic; LR+: positive likelihood ratio; LR-: negative likelihood ratio; PPV: positive predictive value; NPV: negative predictive value.