Challenges in diagnostic accuracy studies in primary care: the fecal calprotectin example

BMC Primary Care

Table 1 Red flag symptoms of IBD

Red flag symptom	Measurement	Positive
Growth failure	Growth calculator	Height for age < -1 SDS
Involuntary weight loss	History	Involuntary decrease in weight
Rectal blood loss	History	Rectal blood loss with defecation
Positive family history of inflammatory bowel disease	History	First-degree relatives
Extra-intestinal symptoms	Physical examination	Eyes (episcleritis, scleritis, uveitis), skin (erythema nodosum, pyoderma gangrenosum, psoriasis), mouth ulcers, finger clubbing, arthritis
Peri-anal lesions	Physical examination	Skin tags, hemorrhoids, fissures, fistulas, abscess
Anemia (Hb)	Hematology	4-12 years < 7.1 mmol/l,
		boy 12-18 years <8.1 mmol/l,
		girl 12-18 years <7.4 mmol/l [22]
CRP	Chemistry	> 10 mg/l [23]
ESR	Hematology	≥ 20 mm/h [23, 24]
Platelets	Hematology	> 450 x 10⁹ /l [24]

SDS = standard deviation score; Hb = hemoglobin; CRP = C-reactive protein; ESR = erythrocyte sedimentation rate.

ISSN: 2731-4553