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Table 1 Red flag symptoms of IBD

From: Challenges in diagnostic accuracy studies in primary care: the fecal calprotectin example

Red flag symptom Measurement Positive
Growth failure Growth calculator Height for age < -1 SDS
Involuntary weight loss History Involuntary decrease in weight
Rectal blood loss History Rectal blood loss with defecation
Positive family history of inflammatory bowel disease History First-degree relatives
Extra-intestinal symptoms Physical examination Eyes (episcleritis, scleritis, uveitis), skin (erythema nodosum, pyoderma gangrenosum, psoriasis), mouth ulcers, finger clubbing, arthritis
Peri-anal lesions Physical examination Skin tags, hemorrhoids, fissures, fistulas, abscess
Anemia (Hb) Hematology 4-12 years < 7.1 mmol/l,
boy 12-18 years <8.1 mmol/l,
girl 12-18 years <7.4 mmol/l [22]
CRP Chemistry > 10 mg/l [23]
ESR Hematology ≥ 20 mm/h [23, 24]
Platelets Hematology > 450 x 109 /l [24]
  1. SDS = standard deviation score; Hb = hemoglobin; CRP = C-reactive protein; ESR = erythrocyte sedimentation rate.