- Research article
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Family physicians’ diagnostic gut feelings are measurable: construct validation of a questionnaire
BMC Family Practice volume 14, Article number: 1 (2013)
Family physicians perceive that gut feelings, i.e. a ‘sense of reassurance’ or a ‘sense of alarm’, play a substantial role in diagnostic reasoning. A measuring instrument is desirable for further research. Our objective is to validate a questionnaire measuring the presence of gut feelings in diagnostic reasoning.
We constructed 16 case vignettes from real practice situations and used the accompanying ‘sense of reassurance’ or the ‘sense of alarm’ as reference labels. Based on the results of an initial study (26 family physicians), we divided the case vignettes into a group involving a clear role for the sense of reassurance or the sense of alarm and a group involving an ambiguous role. 49 experienced family physicians evaluated each 10 vignettes using the questionnaire. Construct validity was assessed by testing hypotheses and an internal consistency procedure was performed.
As hypothesized we found that the correlations between the reference labels and corresponding items were high for the clear-case vignettes (0.59 – 0.72) and low for the ambiguous-case vignettes (0.08 – 0.23). The agreement between the classification in clear sense of reassurance, clear sense of alarm and ambiguous case vignettes as derived from the initial study and the study population’s judgments was substantial (Kappa = 0.62). Factor analysis showed one factor with opposites for sense of reassurance and sense of alarm items. The questionnaire’s internal consistency was high (0.91). We provided a linguistic validated English-language text of the questionnaire.
The questionnaire appears to be valid. It enables quantitative research into the role of gut feelings and their diagnostic value in family physicians’ diagnostic reasoning.
Uncertainty about diagnosing is a typical characteristic of general practice [1, 2]. Gut feelings and some important aspects of context knowledge, i.e. all a family physician knows about a patient apart from the signs and symptoms, are not discussed in traditional textbooks on medical decision-making, but often used by family physicians to support their diagnostic reasoning [3–5]. Chest pain, for instance, may indicate cardiac diseases, gastro-esophageal or pulmonary disorders, but can also be a sign of musculoskeletal or mental illnesses. Since it is impossible in a family medicine setting to define signs and symptoms that prove the presence of myocardial problems,  gut feelings may contribute to the family physician’s medical decision-making. In the case of chest pain such feelings appear to be rather accurate  and in the case of diagnosing serious infections in children, the family physician’s gut feeling ‘that something is wrong’ is in fact the best predictor among all signs and symptoms [8, 9]. The gut feeling ‘this is not normal’ when a physician observes a child has proved to be a sign that makes the physician question the child’s well-being . A qualitative study concluded that certain gut feelings, which could be referred to as a ‘sense of reassurance’ and a ‘sense of alarm’, play a substantial role in family physicians’ diagnostic reasoning . A sense of reassurance means that a family physician feels secure about the further management and course of a patient’s problem, even though he/she may not be certain about the diagnosis: ‘everything fits in’. A sense of alarm implies that a family physician worries about a patient’s health status, even though he/she has found no specific indications yet; it is a sense of ‘there’s something wrong here’. The sense of alarm as a diagnostic tool has been taken seriously by disciplinary tribunals and is even regarded as an element of the professional standards for doctors . Gut feelings are based on the interaction between patient information and a physician’s knowledge and experience,  and can be considered as a kind of skilled intuition . Dual process theories may explain how physician’s analytical reasoning like the use of Bayes theorem and algorithmic decision tools, and their non-analytical reasoning like pattern recognition and gut feelings continually interact as two modes of knowing and thinking [13, 15]. Affect defined as a feeling of ‘goodness’ or ‘badness’ guides the decision making process [16–19]. Cognitive neuroscience research provides support for the view that emotions are a vital component of the decision making process, helping people to thread their ways through the huge amount of information and knowledge [20–22].
In medicine, quantitative research into the actual contribution of gut feelings to physicians’ diagnostic processes is still lacking. Appropriate study designs assessing the diagnostic value of gut feelings, the significance of determinants like experience and context knowledge and the effects of teaching students about gut feelings need an instrument that will be able to determine the presence of gut feelings in diagnostic reasoning [23, 24]. In nursing, some questionnaires have been developed to explore retrospectively the significance of gut feelings in diagnostic reasoning. These questionnaires, however, do not determine the presence or absence of gut feelings in actual clinical reasoning in real practice and have only been applied in research into nursing [25–30]. Moreover, they are not practicable in a general practice setting due to their extensiveness.
Therefore, we composed a short questionnaire that determines the presence of gut feelings in the context of family physicians’ diagnostic reasoning, based on consensus statements obtained in a Delphi procedure about the definition and content of gut feelings in general practice (see Table 1) . The first 6 items in the questionnaire were directly derived from the consensus statements describing the sense of reassurance (item 1) and the sense of alarm (items 2–6) in family physicians’ diagnostic reasoning. The items are rated using a 5-point Likert scale ranging from completely disagree to completely agree. A final item (item 7) was added to assess whether a case vignette elicited a gut feeling (a sense of reassurance or a sense of alarm) or whether this was impossible for the respondent to say or was not applicable.
The objective of the present study was to assess the construct validity of this questionnaire in a group of experienced general practitioners and to determine its factor structure and internal consistency.
Since there is no reference standard for the sense of reassurance and the sense of alarm, and no outcome measures of the concepts have been determined, it is not possible to assess criterion validity. Instead, we performed a construct validation procedure by testing whether the empirical data gathered with the questionnaire corresponded with the expectations based on the theoretical construct, i.e. the concept of gut feelings [32, 33]. To this end, we constructed case vignettes from real practice situations in which gut feelings had played a role, and postulated hypotheses about the relations between the items of the questionnaire and the features of these case vignettes. Figure 1 provides a summary of the study design. The case vignettes can be regarded as an operationalization of the concept of gut feelings. The sense of reassurance or the sense of alarm, assigned to each of these cases was used as reference label.
Selection of case vignettes
Based on real patient cases encountered by the 5 family physicians in the project group, we constructed vignettes of cases in which a sense of reassurance or a sense of alarm had played a role in the diagnostic approach of the attending family physician. After discussion, we accepted 15 case vignettes (5 sense of reassurance and 10 sense of alarm vignettes). Each case vignette had a format starting with the contextual information the family physician already has about the patient, followed by the patient’s complaints and finally additional information gathered during the encounter.
In an initial study, we asked 27 family physicians to evaluate the case vignettes by stating the most likely diagnosis and the treatment approach they would envision, and by completing the gut feelings questionnaire for each vignette. We also asked them to add their comments on the phrasing of the case vignettes. These family physicians participated in an earlier study of gut feelings as members of focus groups and were at the time selected by asking the teaching staff at three Departments of General Practice in the Netherlands for names of non-academic GPs interested in reflecting on diagnostic reasoning . They equally represented both male and female, and experienced and inexperienced family physicians. Half of the participants received case vignettes numbers 1–8 and the other half numbers 8–15. Twenty-six family physicians (42% female, mean number of years of experience = 14, SD = 9) returned completed questionnaires. In 10 of the case vignettes, the sense of alarm (numbers 2, 4, 6, 10, 13, 14) and the sense of reassurance (numbers 1, 5, 8, 12) we expected based on our reference labels were recognized by most of the participants (64–100% agreement). In 5 of the case vignettes, the sense of alarm (numbers 3, 7, 15) and the sense of reassurance (numbers 9, 11) were not consistently recognized by the participants as intended (21–50% agreement). Based on these results, we distinguished between a group of vignettes featuring a clear role for gut feelings (‘clear-case’ vignettes) and a group with a more ambiguous role for gut feelings (‘ambiguous-case’ vignettes). Minor adaptations to the phrasing of the case vignettes were made, based on the comments of the 26 respondents. We also added a 16th illustrative case vignette of a patient visiting an out-of-hours medical service where the sense of alarm played a major role . This case vignette (no. 16) and another one (no. 8) are presented in Table 2.
In accordance with the construct validation procedure, and assuming that the questionnaire could correctly distinguish between a sense of reassurance and a sense of alarm, we then drew up hypotheses about the questionnaire scores (see Table 3).
Finally, we purposively selected 52 experienced family physicians from different regions in the Netherlands, as an earlier study had suggested that the level of experience is positively associated with the use of gut feelings  and invited them by phone to participate. To avoid selection bias, they were told that we were studying the diagnostic reasoning process of family physicians, without mentioning that the purpose of the study was to get information about gut feelings. Each of them received by post a different set of 10 case vignettes, selected so as to balance the number of clear and ambiguous cases, and varying the presentation order. We asked the participants to evaluate the vignettes by stating the most likely diagnosis and the treatment approach they envisioned, and to complete the questionnaire for each vignette. Forty-nine family physicians (63% female, mean number of years of experience = 20, SD = 9) of the 52 invited family physicians completed 10 questionnaires each. The reason to decline was lack of time.
First, to examine whether the items concerning sense of alarm and sense of reassurance formed one or two dimensions, we examined the factor structure employing a Principal Component Analysis. The internal consistency was measured by calculating Cronbach’s alpha, after reversing the polarity of the sense of reassurance item (item 1) .
To examine the hypotheses in our construct validity procedures, we used Spearman’s rank correlations because of the categorical, ordinal nature of the data. We used the usual interpretation of the correlation values: weak < 0.3, moderate 0.3–0.6 and high > 0.6 .
We then used a cross tabulation to visualize the extent of agreement per vignette between the reference labels of the case vignettes and the final judgment (item 7) given by the study population. We also calculated a weighted Kappa using quadratic weights to assess the chance-adjusted agreement between the classification of the case vignettes (3 categories based on the results of the initial study: clear sense of reassurance; ambiguous; clear sense of alarm case vignettes) and the final judgment given by the study population in item 7 (3 categories: sense of reassurance, impossible to say or not applicable, sense of alarm). We used the following interpretation of the Kappa values: < 0.2 = slight, 0.2–0.4 = fair, 0.4–0.6 = moderate, 0.6–0.8 = substantial and > 0.8 = almost perfect . Statistical calculations were performed using SPSS-16.
For this publication and to allow a broad application of the Dutch-language questionnaire we translated the questionnaire into American-English using a formal linguistic validation procedure . This involved two separate forward-backward translations, a consensus meeting and a check on cultural misunderstandings by ten US family physicians [39–41]. The text of the questionnaire is the result of this procedure (see Table 1) (see Endnote).
Since no patients were involved, this research did not fall under the Dutch Medical Research Involving Human Subjects Act (WMO) or the Embryos Act, so that no ethical permission was required.
The Principal Component Analysis showed one factor with the sense of reassurance and the sense of alarm items as two opposites, explaining 70.2% of total variance (see Table 4). The internal consistency of the gut feelings questionnaire was high (Cronbach’s alpha = 0.91).
The first general hypothesis for construct validity, that there is a moderate to high correlation between the reference labels of the clear-case vignettes and the answers given by the 49 family physicians from the validation study to items reflecting the sense of reassurance (item 1) or the sense of alarm (item 2–6), was confirmed (see Table 5). We found a high correlation (0.72) between the reference labels and the final sense of reassurance or sense of alarm judgment (item 7). In addition, when comparing the answers given by the study population, we found a moderate negative correlation (−0.60) between the sense of reassurance item (item 1) and the final sense of reassurance or sense of alarm judgment (item 7). Table 5 shows that the correlations between the sense of alarm items (items 2–6) and the final sense of reassurance or sense of alarm judgment (item 7) were moderate to high (ranging from 0.59 to 0.79). Finally, Table 5 also shows moderate to high inverse correlation patterns for the sense of reassurance item (item 1) and the sense of alarm items (items 2–6) (ranging from −0.45 to −0.63), whereas the intercorrelations between the sense of alarm items (items 2–6) were moderate to high (ranging from 0.56 to 0.84).
The second general hypothesis, that the correlation between the reference labels of the ambiguous-case vignettes and the answers given by the study population to items reflecting a sense of reassurance or a sense of alarm was weak or absent, was also confirmed (see Table 6). We did indeed find that the correlation between the reference labels of the ambiguous-case vignettes and the final sense of reassurance or sense of alarm judgment given by the study population (item 7) was weaker compared to that for the clear-case vignettes (0.16 versus 0.72) (see Tables 5 and 6) and that the correlations between the reference labels and the sense of reassurance item (item 1) or the sense of alarm item (items 2–6) were absent (ranging from 0.05 to 0.24). We also found that the participants’ ratings of the items 1–6 were consistent with their final sense of reassurance or sense of alarm judgments (item 7), as indicated by moderate to high correlations between these ratings and the final judgments (see Table 6).
A cross tabulation visualized per vignette the extent of agreement, between the reference labels of the case vignettes and the final sense of reassurance or sense of alarm judgment (item 7) given by the study population (see Table 7). The table clearly shows that for the clear case vignettes this agreement was substantial or almost perfect (ranging from 62% to 97%), apart from case vignette no. 12 for which agreement was moderate (46%). The results for the ambiguous-case vignettes, however, were mixed: for two (case vignettes (no. 9 and 15) the agreement with the reference labels was substantial (64% and 76%, respectively), whereas agreement was low to fair for the other three vignettes (13%, 25%, and 39%) (see Table 7). In the validation study the family physicians’ final judgment (item 7) thus differed from that of the initial study group on three case-vignettes (no. 9, 12 and 15). Still, the kappa with quadratic weighting showed that chance-adjusted agreement between the classification of the case vignettes as clear sense of reassurance, clear sense of alarm, or ambiguous case-vignettes based on the results of the initial study and the final judgment given in the validation study in item 7 (sense of reassurance, sense of alarm, impossible to say or not applicable) was substantial (0.62, 95% CI: 0.55-0.69).
The purpose of this study was to assess the construct validity of a questionnaire to measure gut feelings in general practice, which was based on consensus statements obtained in a Delphi procedure. The construct validity proved to be good. The correlation patterns were consistent with our hypotheses and there was a substantial agreement in judgments between the family physicians in the initial and the validation study. Factor analysis showed that the questionnaire clearly determined one gut feelings factor, with the sense of reassurance and the sense of alarm as two opposites, and the questionnaire had a high internal consistency. Our questionnaire to determine gut feelings in general practice thus passed an important validation test. The careful linguistic validation procedure makes it appropriate for research across countries. As far as we know, this is the first validated instrument providing a measure of the extent to which a sense of reassurance or a sense of alarm is present during the process of diagnosis. The results of the Delphi consensus procedure can be regarded as a sound basis for the content of the questionnaire. The successful construct validation procedure confirms that gut feelings play a role in family physicians’ diagnostic reasoning process, so now quantitative research can be started to examine their actual contribution.
We tried to compare our gut feelings questionnaire with comparable instruments by performing an English-language search in PubMed and Cinahl using the search terms ‘questionnaire’ [Mesh] OR ‘weights and measures’ [Mesh] AND ‘intuition’ [Mesh] OR ‘gut feelings’ OR ‘sense of reassurance’ OR ‘sense of alarm’. This search only yielded some extensive questionnaires examining the meaning of intuition in the field of nursing [25, 26, 28–30, 42] retrospectively exploring not only the use of intuition and the extent of acknowledgment of intuition, but also other phenomena like physical sensations, premonitions, and reading of cues, cognitive behaviors, experience, skills and clinical thinking. In contrast, our gut feelings questionnaire only aims to determine the presence of a sense of reassurance and a sense of alarm in actual family physicians’ diagnostic reasoning, in observational as well in experimental research designs . The questionnaire is short, easy to complete and feasible for use during routine office hours.
A limitation of our validation approach is that we used the outcomes of the diagnostic reasoning process of the 26 participants of the initial study as a reference to interpret the outcomes in the present validation study. Obviously, we needed such a procedure because there is no gold standard for gut feelings in general practice and we wanted to extend our reference beyond the agreement of the 5 family physicians who were part of the project group. The classification of case vignettes into a clear-case vignette group and an ambiguous one was consistent with actual practice with sometimes vague presentations of disease pictures and diagnostic uncertainty. It allowed us to hypothesize in which cases the correlations between the items in the questionnaire and the reference labels of the case vignettes (i.e., sense of reassurance or sense of alarm) would be moderate to high, or weak to absent. The hypothesized patterns were clearly confirmed by the data, although there were three case vignettes where the classification of the case vignettes as clear sense of reassurance, clear sense of alarm, or ambiguous case vignettes based on the initial study were not consistent with the judgment by the participants of the validation study. Case vignette 12 would now be classified as an ambiguous case, while cases vignettes 9 and 15 would now be classified as clear cases. The shift might be due to differences of experience between the family physicians participating in the initial and validation study and perhaps to the minor adaptations to the phrasing of the case vignettes made after the initial study.
Nevertheless, overall agreement in judgments between the 26 family physicians of the initial study and the 49 family physicians of the validation study was substantial. Moreover, when we based the classification (in further analysis) on the judgments of the 49 experienced family physicians the correlations were even higher for the clear-case vignettes and virtually absent for the ambiguous-case vignettes. We cannot expect full agreement, as gut feelings are based on the interaction between a family physician’s knowledge and experience and the patient information available . As we represented real life situations in the case vignettes in our study, the participants could not further investigate their gut feelings by questioning or examining a patient. Research, therefore, should be extended to real practice situations where additional information can be obtained from patients.
After the validation, our questionnaire can now be used to start further research into the role of gut feelings in diagnostic reasoning, as well as research to assess the significance of the determinants and the effects of educational interventions related to gut feelings. The questionnaire may be useful for studies among specialists and nurses too. A European research agenda on gut feelings  gives the highest priority to questions about the prevalence of a sense of reassurance and a sense of alarm in routine practice and their diagnostic accuracy. Gut feelings may function as a compass in uncertain and complex situations, and now outcomes research may reveal to what extent this tool guides family physicians towards correct decisions and a proper diagnostic management and whether there are differences between experienced family physicians and trainees. Comparisons of situations in which family physicians manage patients they know and patients they see for the first time (e.g. when they are on call) may be used to assess the role of context knowledge. In terms of medical training, an interesting topic would be to study how students, trainee doctors and even experienced practitioners can be trained to develop, recognize and use gut feelings while avoiding pitfalls. In more experimental research, standardized patients or written clinical cases varying in the amount of contextual and patient knowledge could be presented for diagnosis to trainees and family physicians, to study the contribution of major diagnostic cues.
Family physicians’ diagnostic gut feelings are measurable with the validated questionnaire. Diagnostic reasoning belongs to the core business of family physicians, and qualitative research has shown that gut feelings play a substantial part in this process. Our questionnaire should now make it possible to take the next crucial steps toward more quantitative research.
A British-English version has been obtained in a similar way and is available too (http://www.gutfeelingsingeneralpractice.eu).
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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2296/14/1/prepub
The authors are very grateful to the 75 participating family physicians and to Silvia Bours, research assistant.
The authors declare that they have no competing interests.
Conception and design: CF Stolper, MWJ Van de Wiel, HCW de Vet. ALB Rutten, P Van Royen, MA Van Bokhoven, T Van der Weijden, GJ Dinant. Analysis and interpretation of the data: CF Stolper, MWJ Van de Wiel, HCW de Vet, ALB Rutten. Drafting of the article: CF Stolper, MWJ Van de Wiel, HCW de Vet. Critical revision of the article for important intellectual content: P Van Royen, MA Van Bokhoven, T Van der Weijden, GJ Dinant. Statistical expertise: ALB Rutten, HCW de Vet. All authors read and approved the final manuscript.
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About this article
- Gut feelings
- Family medicine
- General practitioners
- Diagnostic reasoning
- Construct validation
- Medical decision-making
- Medical problem-solving
- Clinical reasoning