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Table 4 Strength of Evidence Supporting the Systematic review and Meta-Analysis' Conclusions

From: Predictors of warfarin use in atrial fibrillation in the United States: a systematic review and meta-analysis

Characteristic Conclusion Strength of Evidence Rating
Meta-Analyzable Characteristics
   Alcohol and drug use Reduces warfarin use High
   Increasing age Decreased warfarin use at older ages Moderate
   Coronary artery disease No effect in warfarin use Moderate
   Congestive heart failure Increases warfarin use Moderate
   Contraindications to warfarin Reduces warfarin use High
   Cerebral vascular accident Increases warfarin use Moderate
   Dementia Reduces warfarin use Moderate
   Diabetes No effect on warfarin use Low
   Falls Reduces warfarin use Moderate
   Gastrointestinal bleeding Reduces warfarin use High
   History of bleeding Reduces warfarin use Moderate
   Hepatic impairment Reduces warfarin use Moderate
   Hypertension No effect on warfarin use Low
   Intracranial bleeding Reduces warfarin use High
   Male gender Increases warfarin use Moderate
   Perceived barriers to compliance Reduces warfarin use Moderate
   Renal impairment Reduces warfarin use Moderate
Qualitatively Assessed Characteristics
   Race (African-American or non-White) Reduces warfarin use Moderate
   Geographic region (South) Reduces warfarin use Moderate
   Geographic region (Northeast) Increases warfarin use Moderate
   Malignancy Equivocal Insufficient
   Progressing time Increases warfarin use Moderate
   Specialty of prescriber Equivocal Insufficient
   Insurance status Equivocal Insufficient
   Aspirin or other antiplatelet use Reduces warfarin use Moderate
Perceived appropriateness of warfarin
(appropriate)
Increases warfarin use Moderate
   Perceived/actual risk of bleeding Reduces warfarin use Moderate
Admission source (home/outpatient) for
AF hospitalization
Increases warfarin use Moderate
AF frequency (recurrent, persistent,
permanent)
Increases warfarin use Moderate
   Seizures No effect on warfarin use Low
   Increasing risk of stroke/embolic event Equivocal Insufficient
   Rate of prior healthcare utilization Equivocal Insufficient
  1. AF = atrial fibrillation
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