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Table 4 Number and proportions of patients who used specific antihypertensive drugs and adjusted odds ratios for change

From: Change in antihypertensive drug prescribing after guideline implementation: a controlled before and after study

 

Intervention

Controls

Intergroup comparison

 

2001

2003

Adjusted* OR (95% CI)

p-value

2001

2003

Adjusted* OR (95% CI)

p-value

Adjusted** OR (95% CI)

p-value

 

n (%)

  

n (%)

    

Hypertension, N

2250

2969

  

5504

6717

    

Diuretics

886 (39.4)

1143 (38.5)

0.97 (0.86, 1.08)

0.56

2207 (40.1)

2575 (38.3)

0.92 (0.85, 0.99)

0.02

1.06 (0.92, 1.21)

0.44

Beta-blockers

982 (43.6)

1312 (44.2)

1.04 (0.93, 1.16)

0.50

2335 (42.4)

2890 (43.0)

1.03 (0.96, 1.12)

0.35

1.01 (0.88, 1.15)

0.93

CCBs

560 (24.9)

747 (25.2)

1.04 (0.92, 1.18)

0.55

1349 (24.3)

1682 (25.0)

1.04 (0.95, 1.13)

0.43

0.99 (0.84, 1.14)

1.00

RAAS

738 (32.8)

1108 (37.3)

1.19 (1.06, 1.34)

0.004

1966 (35.7)

2724 (40.6)

1.24 (1.15, 1.34)

<0.0001

0.96 (0.83, 1.10)

0.56

CHD, N

320

440

  

950

1148

    

Diuretics

71 (22.2)

98 (22.3)

1.02 (0.71, 1.46)

0.92

171 (18.0)

229 (19.9)

1.05 (0.84, 1.33)

0.67

0.98 (0.64, 1.50)

0.92

Beta-blockers

235 (73.4)

350 (79.5)

1.39 (0.99, 1.96)

0.06

762 (80.2)

932 (81.2)

1.13 (0.90, 1.41)

0.29

1.25 (0.83, 1.88)

0.29

CCBs

103 (32.2)

113 (25.7)

0.75 (0.54, 1.03)

0.08

203 (21.4)

261 (22.7)

1.06 (0.86, 1.31)

0.59

0.70 (0.48, 1.03)

0.07

RAAS

43 (13.4)

86 (19.5)

1.57 (1.05, 2.34)

0.03

156 (16.4)

218 (19.0)

1.16 (0.92, 1.46)

0.20

1.34 (0.85, 2.12)

0.21

Diabetes, N

302

456

  

612

828

    

Diuretics

115 (38.1)

184 (40.4)

1.10 (0.81, 1.49)

0.54

278 (45.4)

365 (44.1)

0.93 (0.75, 1.15)

0.49

1.19 (0.82, 1.72)

0.37

Beta-blockers

127 (42.1)

216 (47.4)

1.24 (0.93, 1.67)

0.15

275 (44.9)

379 (45.8)

1.03 (0.83, 1.28)

0.76

1.21 (0.84, 1.74)

0.31

CCBs

91 (30.1)

137 (30.0)

0.99 (0.72, 1.37)

0.96

148 (24.2)

223 (26.9)

1.13 (0.88, 1.45)

0.33

0.88 (0.59, 1.32)

0.54

RAAS

159 (52.6)

249 (54.6)

1.08 (0.80, 1.45)

0.64

284 (46.4)

427 (51.6)

1.27 (1.02, 1.57)

0.03

0.85 (0.59, 1.23)

0.39

  1. Prescription data was drawn from the national Prescription Register during a three-month period in 2001 and 2003.
  2. Abbreviations: CCBs, calcium channel blockers; RAAS, agents acting on renin-angiotensin-aldosterone system; CHD, coronary heart disease; OR, Odds ratio; CI, confidence interval.
  3. *Within-group analysis: Logistic regression, random effects model (physician as a random effect). Adjusted for patient's age and patient's sex.
  4. **Intergroup analysis: Logistic regression, random effects model (physician as a random effect). A product term between time (after versus before) and group (intervention versus control) was added in the model. Adjusted for patient's age and patient's sex.
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