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Table 2 Presence of context, signs and symptoms in influenza positive and negative subjects and corresponding crudea and adjusted odds ratios (95%CI)b.

From: Clinical prediction rules combining signs, symptoms and epidemiological context to distinguish influenza from influenza-like illnesses in primary care: a cross sectional study

Contexts. signs and symptoms

Influenza pos

(n = 2409)

Influenza neg

(n = 2175)

Crude OR

(95%CI)

Adjusted OR

(95%CI)

Body temperature >37.8°C. No. (%)

2271 (94.3)

1902 (87.5)

2.36 (1.91 to 2.92)

2.13 (1.58 to 2.68)c

Sudden onset. No. (%)

2154 (89.4)

1874 (86.2)

1.36 (1.14 to 1.62)

1.25 (0.99 to 1.51)

Influenza epidemic. No. (%)

2066 (85.8)

1146 (52.7)

5.41 (4.69 to 6.23)

6.28 (5.03 to 7.54)c

Cough. No. (%)

2060 (85.5)

1425 (65.5)

3.11 (2.69 to 3.59)

2.59 (2.14 to 3.04)c

Shivering. No. (%)

1999 (83.0)

1706 (78.4)

1.34 (1.16 to 1.55)

1.13 (0.92 to 1.33)

Weakness. No. (%)

1965 (81.6)

1691 (77.7)

1.27 (1.10 to 1.46)

1.03 (0.84 to 1.21)

Headache. No. (%)

1918 (79.6)

1590 (73.1)

1.44 (1.25 to 1.65)

1.16 (0.96 to 1.37)

Muscle pain. No. (%)

1838 (76.3)

1567 (72.0)

1.25 (1.09 to 1.43)

1.16 (0.97 to 1.36)

Nose symptoms. No. (%)

1620 (67.2)

1208 (55.5)

1.64 (1.46 to 1.85)

1.38 (1.18 to 1.58)

Red throat. No. (%)

1529 (63.5)

1333 (61.3)

1.10 (0.97 to 1.24)

0.95 (0.81 to 1.09)

Lack of appetite. No. (%)

1453 (60.3)

1130 (52.0)

1.41 (1.25 to 1.58)

1.15 (0.98 to 1.32)

RSV epidemic. No. (%)

1026 (42.6)

1010 (46.4)

0.86 (0.76 to 0.96)

1.14 (0.99 to 1.29)

ILI contacts in the family. school or workplace. No. (%)

928 (38.5)

562 (25.8)

1.80 (1.59 to 2.04)

Not in model

ILI contacts pre/post an epidemic. No. (%). n = 1372

134 (39.1)

180 (17.5)

3.02 (2.31 to 3.96)

3.14 (2.23 to 4.05)c

ILI contacts during an epidemic. No. (%)c. n = 3212

79'4 (38.4)

382 (33.3)

1.25 (1.07 to 1.45)

1.24 (1.03 to 1.44)

Expectoration. No. (%)

661 (27.4)

456 (21.0)

1.43 (1.24 to 1.63)

Not in model

Expectoration on illness day 0. No. (%). n = 117

9 (18.37)

15 (22.06)

0.80 (0.32 to 2.00)

2.24 (0.93 to 3.55)

Expectoration on illness day 1. No. (%). n = 2101

269 (25.33)

165 (15.88)

1.80 (1.45 to 2.23)

1.36 (1.06 to 1.66)c

Expectoration on illness day 2. No. (%). n = 1676

262 (27.61)

159 (21.87)

1.35 (1.09 to 1.71)

1.00 (0.83 to 1.17)

Eye symptoms. No. (%)

659 (27.4)

481 (22.1)

1.33 (1.16 to 1.52)

1.08 (0.90 to 1.27)

Gastro-intestinal symptoms. No. (%)

368 (15.3)

374 (17.2)

0.87 (0.74 to 1.02)

0.84 (0.68 to 1.00)

Ear symptoms. No. (%)

355 (14.7)

304 (14.0)

1.06 (0.90 to 1.26)

0.88 (0.71 to 1.05)

Dyspnoe. No. (%)

236 (9.8)

186 (8.6)

1.16 (0.95 to 1.42)

1.18 (0.90 to 1.45)

Dizziness. No. (%)

233 (9.7)

177 (8.1)

1.21 (0.99 to 1.48)

1.18 (0.87 to 1.48)

Vaccination against influenza. No. (%)

198 (8.2)

267 (12.3)

0.64 (0.53 to 0.78)

0.67 (0.50 to 0.85)

Ronchi. No. (%)

166 (6.9)

136 (6.3)

1.11 (0.88 to 1.40)

0.93 (0.65 to 1.20)

Confusion. No. (%)

22 (0.9)

22 (1.0)

0.90 (0.50 to 1.63)

not in model

Age difference of 10 years

NA

NA

NA

0.97 (0.94 to 1.01)

Age. mean (SE) c

28.90 (0.39)

31.27 (0.41)

NA

Not in model

Temp. mean (SE) c

38.70 (0.01)

38.46 (0.02)

NA

Not in model

  1. NA = not applicable CI = confidence interval
  2. a Crude Odds ratios were estimated using Chi2
  3. b Adjusted odds ratios were estimated using Generalized Estimating Equations. 95%CI were calculated by bootstrap after multiple imputation.
  4. c significant different: p-value < 0.0001