Skip to main content

Table 3 Sensitivity, specificity, and predictive values for different thresholds of the PHQ-9 and the PHQ-2.

From: The Patient Health Questionnaire-9 for detection of major depressive disorder in primary care: consequences of current thresholds in a crosssectional study

PHQ-9 threshold Sensitivity
(95% CI)
Specificity
(95% CI)
PPV
(95% CI)
NPV
(95% CI)
≥4 0.89 (0.84-0.94) 0.64 (0.61-0.67) 0.27 (0.23-0.31) 0.97 (0.96-0.98)
≥5 0.86 (0.81-0.91) 0.75 (0.73-0.77) 0.34 (0.30-0.38) 0.97 (0.96-0.98)
≥6 0.82 (0.76-0.88) 0.82 (0.80-0.84) 0.41 (0.36-0.46) 0.97 (0.96-0.98)
≥7 0.74 (0.68-0.80) 0.87 (0.85-0.89) 0.47 (0.41-0.53) 0.96 (0.95-0.97)
≥8 0.65 (0.58-0.72) 0.90 (0.88-0.92) 0.51 (0.44-0.58) 0.94 (0.93-0.95)
≥9 0.57 (0.50-0.64) 0.93 (0.92-0.94) 0.55 (0.48-0.62) 0.94 (0.93-0.95)
≥10 0.49 (0.42-0.56) 0.95 (0.94-0.96) 0.59 (0.51-0.67) 0.93 (0.92-0.94)
≥11 0.44 (0.37-0.51) 0.96 (0.95-0.97) 0.61 (0.53-0.61) 0.92 (0.90-0.94)
≥12 0.39 (0.32-0.46) 0.97 (0.96-0.98) 0.64 (0.55-0.74) 0.92 (0.89-0.93)
PHQ-9 algorithm 0.28 (0.21-0.35) 0.98 (0.97-0.99) 0.69 (0.58-0.80) 0.90 (0.88-0.92)
PHQ-9 adjusted algorithm 0.84 (0.79-0.89) 0.81 (0.79-0.83) 0.40 (0.35-0.45) 0.97 (0.96-0.98)
PHQ-2 threshold     
≥1 0.90 (0.86-0.94) 0.58 (0.55-0.61) 0.24 (0.21-0.27) 0.98 (0.97-0.99)
≥2 0.81 (0.75-0.84) 0.76 (0.74-0.78) 0.34 (0.29-0.39) 0.96 (0.95-0.97)
≥3 0.42 (0.35-0.49) 0.94 (0.93-0.95) 0.53 (0.45-0.61) 0.91 (0.89-0.93)
≥4 0.31 (0.24-0.38) 0.97 (0.96-0.98) 0.64 (0.54-0.74) 0.90 (0.88-0.92)
≥5 0.19 (0.13-0.25) 0.99 (0.98-1.00) 0.69 (0.56-0.82) 0.89 (0.87-0.91)
≥6 0.14 (0.09-0.19) 0.99 (0.98-1.00) 0.67 (0.52-0.82) 0.88 (0.86-0.90)
  1. For details see text.
  2. PPV: Positive predictive value
  3. NPV: Negative predictive value
  4. 95% CI: 95% Confidence Interval