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Table 2 Clinically important pain outcomes by age and dose group

From: Evaluation of the safety and efficacy of pregabalin in older patients with neuropathic pain: results from a pooled analysis of 11 clinical studies

 

≥30% Pain relief, n (%)

≥50% Pain relief, n (%)

Endpoint pain score ≤3, n (%)*

 

BOCF

LOCF

BOCF

LOCF

 

18-64 years

     

   Placebo

153 (35.7)

163 (38.1)

94 (22.0)

98 (22.9)

111 (25.9)

   Pregabalin 150 mg/d

72 (39.3)

74 (40.4)

45 (24.6)

46 (25.1)

50 (27.3)

   Pregabalin 300 mg/d

109 (48.0)

120 (52.9)

73 (32.2)

82 (36.1)

92 (40.5)

   Pregabalin 600 mg/d

199 (51.3)

236 (60.8)

153 (39.4)

179 (46.1)

170 (43.8)

65-74 years

     

   Placebo

73 (24.6)

80 (26.9)

47 (15.8)

51 (17.2)

57 (19.2)

   Pregabalin 150 mg/d

45 (34.6)

48 (36.9)

31 (23.8)

32 (24.6)

34 (26.2)

   Pregabalin 300 mg/d

56 (44.8)

68 (54.4)

38 (30.4)

46 (36.8)

43 (34.4)

   Pregabalin 600 mg/d

109 (54.0)

132 (65.3)

83 (41.1)

99 (49.0)

91 (45.0)

≥75 years

     

   Placebo

39 (21.0)

42 (22.6)

22 (11.8)

23 (12.4)

24 (12.9)

   Pregabalin 150 mg/d

40 (35.7)

46 (41.1)

28 (25.0)

32 (28.6)

36 (32.1)

   Pregabalin 300 mg/d

43 (30.1)

64 (44.8)

30 (21.0)

42 (29.4)

38 (26.6)

   Pregabalin 600 mg/d

24 (33.8)

41 (57.7)

18 (25.4)

32 (45.1)

35 (49.3)

  1. LOCF, last observation carried forward; BOCF, baseline observation carried forward.
  2. *Pain score ≤3 at endpoint on the Daily Pain Rating Scale (0 = no pain to 10 = worst possible pain) based on LOCF analysis.