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Table 5 Diagnostic performance of the 4DSQ and HADS depression scales with respect to detecting any major depressive disorder (prevalence 49%)*

From: Detecting depressive and anxiety disorders in distressed patients in primary care; comparative diagnostic accuracy of the Four-Dimensional Symptom Questionnaire (4DSQ) and the Hospital Anxiety and Depression Scale (HADS)

4DSQ depression

sensitivity

specificity

PPV

NPV

ā‰„1

0.96

0.34

0.59

0.89

ā‰„2

0.88

0.46

0.62

0.80

ā‰„3

0.78

0.60

0.66

0.74

ā‰„4

0.65

0.72

0.69

0.68

ā‰„5

0.53

0.79

0.71

0.63

ā‰„6

0.45

0.83

0.71

0.60

ā‰„7

0.32

0.87

0.71

0.57

ā‰„8

0.25

0.92

0.75

0.56

ā‰„9

0.18

0.93

0.72

0.54

ā‰„10

0.12

0.97

0.78

0.53

HADS depression

ā‰„7

0.97

0.30

0.57

0.92

ā‰„8

0.93

0.39

0.60

0.84

ā‰„9

0.88

0.49

0.63

0.81

ā‰„10

0.84

0.60

0.68

0.80

ā‰„11

0.75

0.67

0.69

0.73

ā‰„12

0.60

0.75

0.70

0.65

ā‰„13

0.49

0.78

0.69

0.61

ā‰„14

0.40

0.88

0.77

0.60

ā‰„15

0.32

0.89

0.73

0.57

ā‰„16

0.21

0.93

0.74

0.55

ā‰„17

0.16

0.96

0.79

0.54

  1. * For each scale three cut-off points are highlighted in bold type: the optimal cut-off point with the best balance between sensitivity and specificity, the best lower cut-off point with a sensitivity ā‰„0.85, and the best higher cut-off point with a specificity ā‰„0.85
  2. 4DSQ = Four-Dimensional Symptom Questionnaire
  3. HADS = Hospital Anxiety and Depression Scale
  4. PPV = positive predictive value
  5. NPV = negative predictive value