Effectiveness of IT-based diabetes management interventions: a review of the literature
© Costa et al; licensee BioMed Central Ltd. 2009
Received: 20 April 2009
Accepted: 17 November 2009
Published: 17 November 2009
Information technology (IT) is increasingly being used in general practice to manage health care including type 2 diabetes. However, there is conflicting evidence about whether IT improves diabetes outcomes. This review of the literature about IT-based diabetes management interventions explores whether methodological issues such as sample characteristics, outcome measures, and mechanisms causing change in the outcome measures could explain some of the inconsistent findings evident in IT-based diabetes management studies.
Databases were searched using terms related to IT and diabetes management. Articles eligible for review evaluated an IT-based diabetes management intervention in general practice and were published between 1999 and 2009 inclusive in English. Studies that did not include outcome measures were excluded.
Four hundred and twenty-five articles were identified, sixteen met the inclusion criteria: eleven GP focussed and five patient focused interventions were evaluated. Nine were RCTs, five non-randomised control trials, and two single-sample before and after designs. Important sample characteristics such as diabetes type, familiarity with IT, and baseline diabetes knowledge were not addressed in any of the studies reviewed. All studies used HbA1c as a primary outcome measure, and nine reported a significant improvement in mean HbA1c over the study period; only two studies reported the HbA1c assay method. Five studies measured diabetes medications and two measured psychological outcomes. Patient lifestyle variables were not included in any of the studies reviewed. IT was the intervention method considered to effect changes in the outcome measures. Only two studies mentioned alternative possible causal mechanisms.
Several limitations could affect the outcomes of IT-based diabetes management interventions to an unknown degree. These limitations make it difficult to attribute changes solely to such interventions.
Recent advances in Information Technology (IT) have been used to manage chronic diseases including diabetes mellitus. Specifically, IT can enhance communication among health professionals (HPs) and patients , and improve diabetes management . A number of IT applications are currently available including electronic patient registers, electronic decision support systems, videoconferencing, telemedicine, biometric devices capable of uploading information such as blood glucose test results to the Internet or the HP's computer and Internet-based interactive patient support networks .
Type 2 diabetes mellitus is a chronic progressive disease associated with long term complications and high morbidity and mortality rates . Between 1999 and 2000 the Australian prevalence of diabetes was 7.4%  and is projected to reach 15% by 2031 . Type 2 diabetes accounts for 85% to 96% of all diagnosed cases and is reported to be largely due to lifestyle factors such as calorie dense diets, obesity and inactivity .
Diabetes management includes achieving HbA1c < 7%, reducing hyperglycaemia symptoms, preventing complications, appropriate self-care, and enhancing quality of life [7, 8]. In Australia, general practitioners (GPs) receive financial incentives to use structured GP management plans (GPMPs) and work collaboratively with nurses and allied HPs in Team Care Arrangements (TCAs) to manage a number of chronic diseases including diabetes. Interdisciplinary TCAs can result in diabetes care consistent with management guidelines and HbA1c close to 7% . However, diabetes management is often inadequate despite care plans .
Barriers to using diabetes interventions in general practice identified in the literature.
Amount of documentation required to claim *EPC items
Inconsistency between chronic disease care and acute care-oriented systems
Conflicting patient and +GP care goals
Inadequate knowledge about available #AH services
Inadequate training to work within interdisciplinary teams
Difficulty communicating with other °HPs
Long waiting lists
No practice nurses employed within the practice
Unsure of process
Perception that the items were too business-focused
α IT-based diabetes interventions
Concerns about confidentiality
Anxiety about change
One Australian study explored GP's and HP's use of computer-based GPMP and TCA templates to plan diabetes care . GPs and HPs had both positive and negative views about the templates (Table 1). One reason could be that electronic templates have not addressed many of the barriers to using care plans shown in Table 1. The authors concluded that, while GPs used the templates to claim Medicare items, most did not feel care plans improved the overall care of patients with chronic diseases .
A recent literature review examined 29 IT-based diabetes management intervention studies using electronic medical records (EMR) and undefined web-based programs, within general practice . Several benefits of IT-based interventions were discussed and a number of barriers were identified, including some of those shown in Table 1.
The review found the frequency with which diabetes-specific investigations were performed increased following the introduction of IT-based interventions . However, improved HbA1c and cholesterol levels were inconsistent among the studies reviewed. The review did not scrutinise the study methodologies. It is possible that methodological factors could have influenced the results, and need to be taken into account to determine whether they could help explain the inconsistent findings. Thus, using IT in diabetes management does not appear to have overcome existing IT management barriers in general practice, especially time constraints and inadequate training.
The aim of the current review of the literature about IT-based diabetes management interventions was to determine the extent to which methodological issues could explain the inconsistent findings among studies that examined the effect of IT-based management interventions on diabetes outcomes. The review was undertaken to answer the following question: what are the methodological limitations associated with (1) sample characteristics, (2) outcome measures and (3) mechanisms causing change in the outcome measures of studies that evaluated IT-based diabetes management interventions in general practice? Cost-benefit and cost-effectiveness issues are not addressed in this paper.
Databases searched included the Medical Literature Analysis and Retrieval System Online (Medline), the Cumulative Index to Nursing and Allied Health Literature (CINHAL), PubMed, and the American Psychological Association Online Database (PsychInfo). The reference lists of extracted articles were hand searched for additional relevant articles. Search terms using the Medical Subject Headings (MeSH) thesaurus were: diabetes mellitus, type 2/or diabetes mellitus AND disease management AND informatics OR computerised medical records systems.
Original articles that evaluated an IT diabetes management intervention in general practice published between 1999 and 2009 inclusive in English were reviewed. These included randomised control trials (RCTs) and pretest-post-test designs.
Articles that evaluated IT diabetes management interventions in hospital settings or other chronic diseases were excluded. Articles that did not include diabetes-related metabolic outcomes (HbA1c, lipids, renal function) as a primary outcome measure, literature review papers, and opinion articles were also excluded.
Titles and abstracts were independently reviewed by two of the authors during January and February 2009. Following the initial abstract review, complete articles were retrieved if they met the inclusion criteria. The Australian National Health and Medical Research Council (NHMRC) guidelines for appraising the quality of intervention studies  were used to assess the studies reviewed. Where the eligibility of an article was unclear, the authors engaged in discussion until consensus was reached. A systematic review of the relevant studies was not conducted because the study designs and evaluated interventions were heterogeneous. Therefore, guidelines for undertaking systematic reviews such as the PRISMA statement  were not followed.
Summary of the 16 Studies Reviewed
Cluster blind RCT
Electronic decision support system
Electronic self-management system
Electronic self-management system
Electronic self-management system
Electronic self-management system
Nonrandomised cluster control trial
Electronic management system
Nonrandomised control trial
Nonrandomised control trial
Personal Digital Assistant (PDA) based electronic management system
Nonrandomised control trial
Nonrandomised control trial
Electronic decision support system
Single sample before and after design
Single sample before and after design
Nine studies were RCTs; three involved randomisation by GP clusters and two by patients. Only one RCT indicated that blinding procedures were used. Five studies were non-randomised control trials. Two studies used a single sample before and after design.
Limitations associated with study outcomes in 16 studies reviewed
No control group 
Short duration of the intervention [, 1623]
Small sample size 
Sampling population restricted to patients who accessed hospital web page 
Unmeasured variable contributing to observed change 
Concomitant exposure to another intervention 
Non-random participant dropout 
Complete data not available for all participants 
Nine studies included both type one and type two diabetes patients, two of these evaluated patient-focused interventions [22, 23]. None of the studies examined the effect of diabetes type on the outcome measures.
The IT-based interventions had varying degrees of IT complexity. Yet patient and GP baseline levels of familiarity and confidence in their ability to use computers were not reported. Diabetes knowledge at baseline was not reported in any of the studies reviewed, even though a main component of patient-focused interventions consisted of providing self-management education.
All of the studies reviewed included HbA1c as a primary outcome. One study included HbA1c as the only outcome measure . Nine studies reported a significant reduction in mean HbA1c at three months , six months [23, 28], 12 months [17–19], three years  and five years . Of these, one RCT  and one non-randomised control trial  reported significantly lower mean HbA1c in the intervention groups compared to controls at follow up (p < 0.05). One study reported that minimal use of diabetes registers was associated with an increase in mean HbA1c from 7.4 at baseline to 7.8 at follow up (p < .05) . Two of the studies reported the HbA1c assay method [21, 22]. A change in the HbA1c assay method during one study led to significantly lower HbA1c concentrations .
Mean baseline HbA1c in eight of the studies reviewed ranged between 7.0 and 7.3% [15, 17–20, 23, 24, 26]. Interventions introduced when the mean baseline HbA1c was 9.0 - 11.0% were associated with a significant improvement in HbA1c (7.5 - 7.68%).
Cholesterol levels were assessed in all the studies reviewed except one . Ten studies measured blood pressure [15–19, 22–24, 26, 28], two studies measured weight [23, 28], and one measured creatinine . Eight assessed GP adherence to diabetes complication screening guidelines; five assessed whether diabetes-specific metabolic indicators were documented in patient files [16, 17, 29, 21, 25] and six studies assessed whether annual foot and eye tests were performed [16, 17, 20, 24, 26, 27]. GP adherence measures assessed could not be found in one study .
Five studies reported prescribed oral hypoglycaemic agents (OHAs) and insulin [15, 16, 22, 25, 28]. Four of these measured the change in the proportion of participants prescribed OHAs and insulin at baseline and follow up [15, 16, 25, 28]. The number of patients that were prescribed these medicines increased over a 21 month period.
Two studies reported psychological outcomes; specifically self-efficacy and depression. One study reported increased self-efficacy using the Diabetes Self-Efficacy Scale (DSES)  following the introduction of a patient-targeted IT intervention . A second study reported the prevalence of depression reduced from 19% to 12% in the intervention group and 16% to 13% in the comparison group in a 12-month evaluation of a patient-directed electronic assessment and action plan software program . Patient lifestyle factors were not reported in any of the studies reviewed.
Mechanisms Causing Change in the Outcome Measures
The causal mechanism responsible for changes in the outcome measures in the studies reviewed was an IT-based intervention. Three studies acknowledged that increased attention to diabetes care or some unmeasured factor could have contributed to the changes observed in outcome measures [15, 25, 30].
Nine of the studies reviewed identified an association between the IT intervention used and the outcome measures [17–19, 21–23, 28–30]. However, caution should be exercised in interpreting the findings of studies, which evaluated IT-based diabetes management interventions because a number of different confounding factors may have influenced the outcomes, some of which were considered in the current paper.
In IT-based diabetes intervention evaluation studies, sample characteristics such as diabetes type, familiarity with IT, and baseline diabetes-related knowledge and skills may be important factors that could influence the results. None of the studies appeared to address any of these factors. While RCT randomisation procedures aim to reduce the effect of known and unknown confounding variables  it may not be possible to eliminate their effect completely. Furthermore, randomisation was not undertaken in seven of the studies reviewed [24–30]. A lack of randomisation may have increased the risk of bias when assigning participants to intervention and control groups. This may have influenced the outcome measures to an unknown degree.
Type one diabetes is unique in that management always involves medication, whereas type two diabetes may be managed using diet and lifestyle. These differences could influence individuals' self-management strategies and affect outcome measures.
Familiarity with IT
Cognitive ability affects engagement with technology such as learning new skills and new ways of performing familiar tasks such as emailing, participating in chat rooms and navigating the Internet . Advanced disease progression, multiple co-morbidities, and natural ageing, may reduce the cognitive capacity of participants to learn the skills necessary to engage with IT-based interventions. Thus, cognitive ability could have influenced the outcome measures of some studies to an unknown degree, but was not discussed in the studies reviewed.
Type 2 diabetes is common in older adults (> 60 years) . Compared with younger adults, older adults report greater anxiety about using computers, lower use of technology  and less confidence in their ability to use computers . Therefore, some patients may have experienced anxiety about engaging in computer-related interventions such as accessing support materials on the Internet and uploading blood glucose test results to study websites. However, these potential confounders were not explored or discussed in any of the studies reviewed.
GPs' initial level of computer literacy and experience with the technology may influence their acceptance and use of new informatics-based interventions [36, 37]. Some GPs who trained before the introduction of computers into general practice may be less confident to use them than other GPs, such as more recently trained GPs. High levels of computer anxiety may be associated with reluctance to engage with online interventions to an unknown degree. Therefore, when evaluating any new IT intervention in general practice it is important to examine professionals' perceptions and acceptance of the technology, because these factors could influence the outcomes of the intervention, yet this was not assessed in any of the studies reviewed.
Not all patients with diabetes will benefit from an IT-based management intervention . Many individuals, particularly those diagnosed many years prior to participating in an intervention study, may have already developed strategies and acquired the relevant knowledge to manage their diabetes with minimal professional intervention. In particular, patients who are able to maintain their HbA1c close to 7% may have well developed self-management strategies and knowledge. Self-management education interventions may only be effective for participants with inadequate diabetes-specific knowledge. Therefore, it may be of value to assess diabetes knowledge and skill levels prior to introducing interventions that aim to up-skill individuals with diabetes. This was not reported in any of the studies reviewed.
Diabetes Management Goals
HbA1c was the primary outcome measure used in the studies reviewed. HbA1c provides an average measure of blood glucose over the previous 90 to 120 days . It is an objective measure of glycaemic control and is unaffected by self-report bias. However, a number of factors can affect HbA1c and thus influence the outcome. First, frequent hypoglycaemic episodes, anaemia, haemoglobinopethies and excessive blood loss can lower HbA1c . These factors were not assessed in any of the studies reviewed. Likewise, they are rarely, if ever, considered when developing care plans.
Second, HbA1c may be an appropriate outcome measure only when it is elevated at baseline. Individuals with good diabetes self-management before participating in an IT-based intervention may not derive any benefit from participation and may confound study results. IT diabetes management interventions may need to be introduced to populations where diabetes is poorly controlled in order to effect changes, as was the case in three of the studies reported [22, 28, 29].
Third, there may be interlaboratory variations if HbA1c was not measured in the same laboratory. Thus, it may be unwise to make comparisons among studies using different laboratories for HbA1c results. As well as process and structure outcomes, psychological state, medication status and lifestyle factors need to be assessed.
When lifestyle changes alone do not control blood glucose levels among people with type 2 diabetes, glucose lowering medications (OHAs or insulin) are introduced . Medications, doses, and dose intervals are altered over time as needed to maintain metabolic control. Therefore, medication status at baseline and changes over time can provide an indication of disease progression in type 2 diabetes. None of the studies reviewed assessed the effect of OHAs or insulin on outcomes or whether the medicine regimens changed because of the IT interventions. Without such information, it is not possible to tease out the effects of OHAs or insulin on outcomes or to attribute change solely to IT-based interventions.
Psychological factors were rarely measured in any of the studies reviewed. However, a range of psychological variables can influence glycaemic control. High levels of diabetes self-efficacy are directly associated with lower HbA1c [38, 39], yet only one study measured changes in self-efficacy following the introduction of an IT-based intervention . One study evaluated a patient-directed IT intervention that used electronically delivered strategies to enhance diabetes self-efficacy beliefs and self-management behaviours, yet did not report self-efficacy as an outcome measure . While the authors reported an improvement in HbA1c following the intervention, it is not clear whether the change was due to a change in participants' self-efficacy, the intervention, or any other factor. Thus, caution must be exercised when attributing the findings of this study to the IT intervention.
Depression is common among people with diabetes and is associated with poor metabolic control, poor treatment adherence and reduced quality of life , and may influence outcomes of studies evaluating new diabetes management interventions. Yet depression was only considered in one of the studies reviewed . Furthermore, there is only limited evidence that IT-based interventions reduce depression, therefore the variable causing a change in depression levels in Glasgow et al.'s study , is unclear. Being part of a study or receiving increased attention and care from HPs may reduce depression among study participants rather than the intervention.
Social and lifestyle factors influence how well people manage their diabetes. Income and education deficits are associated with inadequate self-care, and affect diabetes outcomes . Inadequate diabetes-related knowledge and skills impair people's ability to successfully undertake self-management . However, lifestyle factors were not reported in any of the studies reviewed, and represents a significant limitation of the current literature.
Mechanisms Causing Change in the Outcome Measures
The first possible mechanism responsible for reported changes in outcome measures, the mechanism considered in all of the studies reviewed, was the IT mode of delivery. That is, delivering diabetes management interventions electronically is a possible mechanism causing change in the outcome measures. However, factors other than the method of delivery could contribute to observed changes in outcome measures.
Good diabetes management and GP adherence to management guidelines may partially account for changes in HbA1c. Most of the studies reviewed compared the IT-based intervention to standard diabetes management. Appropriate diabetes management effects a change in outcome measures, regardless of the mode of delivery. Yet the appropriateness of people's management regimens was not discussed. It is unethical to withhold treatment with proven efficacy in order to provide a control group for IT interventions. However, the possibility that diabetes management per se and not the IT method influenced outcomes should be considered.
Participating in research can influence outcome measures. Individuals who choose to take part in a research study may be motivated to perform well to help the researcher and confirm to themselves their contribution is valuable . Therefore, participating in an IT-based intervention study may have influenced self-management behaviours in both the intervention and comparison groups, and in turn affected the outcomes, but this possibility was not acknowledged in any of the studies reviewed.
There are several limitations to the current review, which could affect the conclusions. First, a systematic literature review was not undertaken because of the heterogeneity of the interventions and study designs of the literature identified. Second, while a search strategy was used, the review may have omitted important studies evaluating other IT-based diabetes management interventions. Finally, the review did not identify any studies conducted within Australia. The Australian health system is unique to the health systems of both the United Kingdom and the United States, where the majority of the studies reviewed were conducted. The availability of financial incentives for using structured care planning within Australia may influence GPs' use of IT-based diabetes management interventions to an unknown degree.
Given the growing diabetes epidemic, effective diabetes management interventions suited to general practice are needed. Due to the limitations of the studies reviewed, the effectiveness of current IT-based interventions is unclear and difficult to attribute solely to the interventions. Future research efforts must give thoughtful attention to methodological issues to produce valid, reliable and generalisable findings. In particular, possible confounding factors need to be acknowledged and controlled, outcome measures need to be relevant to the populations being studied and appropriate methods used to address study aims.
The work was supported by funding from the Australian Government under the Clever Networks program and by the Victorian Government Department of Innovation, Industry and Regional Development.
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